M1 macrophage
Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment
... M2/M1 macrophage ratio is not obvious, which is consistent with the lack of synergy in inhibition of tumor ...M2/M1 macrophage ratio in the tumor microenvironment, ...
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Zoledronic acid exacerbates inflammation through M1 macrophage polarization
... during M1 macrophage differentiation ...M2 macrophage-related molecules such as IL-10, IL-1ra, and CD206 during M2 macrophage differen- tiation induced by IL-4 treatment ...of M1 but ...
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Original Article Inhibition of M1 macrophage specific gene expression and promotion of M2 macrophage specific gene expression by bone mesenchymal stem cells
... into M1 macrophages, while IL-4 was applied to irritate and induce ...with M1 and M2 macrophages, were cultivated for 24 hours; and the macrophages and supernatant were collected to analyze the changes of ...
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First case report of M1 macrophage polarization in an untreated symptomatic patient with toxoplasmosis
... membrane macrophage CD68 marker has been shown to identify M1 macrophages in human tissues ...the M1 macrophage sub- set. Using this method we identified M1 macrophages in a human ...
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Osteoarthritis associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
... BCP crystals have previously been reported to upregulate the expression of in fl ammatory and catabolic mediators in a number of cell types implicated in OA 24,46e48 . Our results show that, in addi- tion to cytokines, ...
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Original Article Hydrogen mitigates acute lung injury through upregulation of M2 and downregulation of M1 macrophage phenotypes
... and macrophage phenotypic changes were assessed in bronchoalveolar lavage fluid ...decreased M1 macrophage phenotypes while increased M2 macrophage pheno- ...decreased M1 ...
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Natural killer T cell activation increases iNOS+CD206- M1 macrophage and controls the growth of solid tumor
... M2 macrophage while M1 macrophages are resistant to lysis ...frequency macrophage polarization in the tumor microenvironment is not clearly ...+ M1 macrophages while reducing the frequency of ...
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GWAS identified CCR1 and IL10 loci contribute to M1 macrophage predominant inflammation in Behçet’s disease
... inhibiting M1 Mφ function, because we have previously shown that HO-1 mRNA expression in circu- lating monocytes is increased during treatment with infliximab in patients with rheumatoid arthritis ...corrected ...
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An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
... identified macrophage population mounts an unrestrained proin- flammatory M1 activation phenotype and accumulates iron in ...for M1 and M2 macrophage activation markers TNF-α and CD206 or ...
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Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma
... in macrophage migration was also obtained when THP-1 cells were transiently transfected with siRNA against S1PR1 (Figure ...the macrophage migration induced by the CM from melanoma ...S1P-induced ...
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Up regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection
... the M1-inflammatory ...influenced M1-polarization by decreasing IL-12, CD100 and TfR1, as well as up-regulating CD163 and MMPs, implying compromised cell ...an M1-polarization antagonized ...inducing ...
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Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88
... Results: Upon exposure to LPS, the secretion of TNF- α and transcription of inflammatory factors in macrophages increased, cell morphology changed and protrusions appeared gradually, the proportion of F4/80 + CD11c + ...
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TREM 1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population
... the macrophage phenotype from M2 to ...with M1 macrophage markers (CD86, CCR7 and iNOS) expression was found in the omentum biopsies of both obese diabetics and non-diabetics, sup- porting the ...
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Adipocyte secreted exosomal microRNA 34a inhibits M2 macrophage polarization to promote obesity induced adipose inflammation
... the M1 polarization and production of pro inflammatory cytokines from macrophages, although the specific exosomal components driving these changes remain ...on M1 macrophage polarization and ...
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MiR-101 targets DUSP1 to regulate the TGF-β secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma
... confirmed macrophage polarization and differentiation in both cell types, whereas differential expression of CD206 indicated an alternative polarization state in M2 macrophages (Figure ...into M1 and M2 ...
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Original Article Effect of rTsP53 on the M1/M2 activation of bone-marrow derived macrophage in vitro
... Abstract: We investigated that if rTsP53 could be used to activate bone-marrow derived macrophage (BMDM) into M2 macrophage and stop M1 macrophage activation. After 72 h incubation in blank ...
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The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats
... Furthermore, M1 produces high level of oxidized metabolic substances, such as NO, super- oxides, pro-inflammatory factors, IL-12, IL-1β, IL-15, IL-18, TNF-α, CCL15, and ...[39,40]. M1 can inhibit neurite ...
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Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis
... proinflammatory M1 macrophage genotype and phenotype ...to macrophage differ- entiation by analyzing the ability of DLL4 to interfere with M2 ...promoting macrophage differentiation towards ...
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TGF- induces M2-like macrophage polarization via SNAIL- mediated suppression of a pro-inflammatory phenotype
... The M2 phenotype is not only induced by IL-4 or IL-13, but also by other stimuli like IL-10, immune complexes, glucocorticoids, and transforming growth factor-β (TGF-β), which leads to variation within the M2-like cells ...
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Macrophage phenotypes correspond with remodeling outcomes of various acellular dermal matrices
... an M1 or M2 phenotype based on re- ceptor expression, mechanism of activation and ...of macrophage phenotype upon tissue remodeling following implantation of an acellular dermal matrix (ADM) is largely ...
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