Macrophages/Kupffer cells
Uptake of toxic silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition
... incubated at 37 degrees C with silica particles in the presence or absence of autologous or heterologous plasma or purified plasma fibronectin and cell viability was assessed at various times. Within 60 min of ...
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Kupffer cells are central in the removal of nanoparticles from the organism
... in Kupffer cells, i.e. in the macrophages of the liver ...other cells than macrophages were seen in any of the organs examined in this study and sections from the con- trol animals were ...
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Th2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis without Inducing Local Inflammation
... fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and ...Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound ...
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Infection of Primary Cultures of Human Kupffer Cells by Dengue Virus: No Viral Progeny Synthesis, but Cytokine Production Is Evident
... human Kupffer cells efficiently since more than 80% of Kupffer cells had viral particles in their cytoplasm that were visible under an electron microscope 1 h after ...of Kupffer ...
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Kupffer cells in immune activation and tolerance toward HBV/HCV infection
... Kupffer cells (KCs) are macrophages that are found in the sinusoids of the ...endothelial cells together form the first immune barrier of the portal ...
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The balancing act of the liver: tissue regeneration versus fibrosis
... mature cells or acti- vation of facultative progenitors, this process relies on stromal signals (from LSECs, myofibroblasts, and/or macrophages) to fine-tune epithelial cell-fate choices according to local ...
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The innate immune receptor TREM 1 promotes liver injury and fibrosis
... myeloid cells 1 (TREM-1), an amplifier of inflammation, promotes liver disease by intensifying hepatic inflammation and ...liver macrophages and monocytes and was highly upregulated on Kupffer ...
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Defective Initiation of Liver Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6/Stat3 Pathway
... in macrophages after stimulation by cytokines such as IL-6, TNFα, IL-1β and IFNγ [7, ...of Kupffer cells isolated from normal rats, suggesting that OPN may act as a chemoattractant to recruit ...
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Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement
... Macrophages express multiple receptors for Igs and comple- ment, and future investigation will be needed to delineate the mechanisms by which KCs recognize Ad that has been opso- nized with IgM and complement. ...
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Immunohistochemical Aspects of Ito and Kupffer Cells in the Liver of Domesticated and Wild Ruminants
... mesenchymal cells (epithelial to mesenchymal tran- sition) [11]. Kupffer cells are the liver resident macro- ...of macrophages [12], which are key components of the innate immune system [13] ...
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Distribution of heme oxygenase isoforms in rat liver Topographic basis for carbon monoxide mediated microvascular relaxation
... by macrophages in the liver and spleen, while hemoglobin released as a consequence of eryth- rocyte destruction can be metabolized mainly in the liver pa- ...in Kupffer cells of the control liver ...
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Lactoferrin Protects against Development of Hepatitis Caused by Sensitization of Kupffer Cells by Lipopolysaccharide
... activate macrophages (7). Interaction with zymo- san will activate macrophages to produce inflammatory cyto- kines ...primed macrophages will react to small doses of LPS to promote a burst of ...
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Cell specific expression of transforming growth factor beta in rat liver Evidence for autocrine regulation of hepatocyte proliferation
... endothelial cells, Kupffer cells (liver macrophages), and lipocytes (Ito or stellate cells) from normal and regenerating ...endothelial cells and Kupffer ...
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Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization
... antigen-positive Kupffer cells and alveolar macrophages suggests viral phago- cytosis or immune complex sequestration rather than viral rep- ...human Kupffer cells showed that these ...
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The role of liver microenvironment in hepatic metastasis
... mesenchymal cells allows for migration to the bloodstream, which acts as a highway for tumor ...tumor cells at a certain loca- tion. Individual cells detected in patient serum are known as ...
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The role of the liver in the migration of parasites of global significance
... After being deposited in the skin from a mosquito bite, sporozoites migrate to the liver via the blood. To enter the liver, the sporozoites must cross the fenestrated endothelial layer; however, the fenestrations are too ...
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Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis
... liver Kupffer cells (F4/80+, green) from BALB/c mice treated with clodronate for 24 h following ...liver Kupffer cells (F4/80+, green) from BALB/c mice treated with 4T1 ENVs for 24 h following ...
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Effect of sleep deprivation on the liver, kidney and heart: histological and immunohistochemical study
... Sleep deprivation induced renal dysfunction indicated by elevated BUN. 26 It also leads to circadian rhythms disruption that Integrity of peripheral organs such as the kidney depends on the circadian coordination. ...
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Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole
... compared with controls. However, the level of ALP in the experimental groups reduced significantly. TCZ injection also caused damages including necrosis, hepatocyte degeneration, triad fibrosis, bile duct hyperplasia, ...
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7. Immunity.pdf
... 1. Class I MHC molecule: It is found on every cell in human body. It is specifically responsible for presentation of endogenous antigens (antigens produced intracellularly such as viral proteins and tumor antigens) to ...
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