Main protease
Characterization of Bafinivirus Main Protease Autoprocessing Activities
... viral main protease (M pro ) of the type species, White bream virus (WBV), of the newly established genus Bafinivirus (order Nidovirales, family Coronaviridae, subfamily ...serine protease that uses ...
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The main protease of SARS-CoV-2 as therapeutic target to development specific drugs to treat COVID-19
... The pandemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) denominated COVID-19 is an important problem of world public health because do not have specific drugs and vaccines available to ...
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Hydroxychloroquine as Potent Inhibitor of COVID -19 Main Protease: Grid Based Docking Approach
... to prevent/treat an attack is a major need at this time. Drug discovery against the CoV is a challenging task owing to re- current recombination events. Developing a a vaccine is an- other important issue. However, ...
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Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
... Coronaviruses (CoVs) have the largest genome size among all RNA viruses. CoV infection causes various diseases in humans and animals, including severe acute respiratory syndrome (SARS) and Middle East respiratory ...
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High throughput virtual screening to discover inhibitors of the main protease of the coronavirus SARS-CoV-2
... SARS-CoV-3 main protease, which would explain the age divide in terms of COVID-19 severity. This hypothesis is supported by the fact that progesterone was identified to be antiviral against SARS-CoV-2 [64]. ...
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High throughput virtual screening to discover inhibitors of the main protease of the coronavirus SARS-CoV-2
... Compound 3. This compound belongs to the steroid class. It is an approved drug called dutas- teride (MW 528.5 g/mol) and is used because of its effectiveness as a 5α-reductase inhibitor, which converts testosterone to ...
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Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA
... The docking study of the compound over COVID-19 Mpro was studied using Molegro Virtual Docker (MVD) program. The crystal structure of a protein essential for virus replication download from protein data bank web site ...
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Identification of Pharmacophoric features and novel compounds for inhibition of SARS-Cov-2 Main Protease
... CoV-2 main protease. SARS-CoV-2 main protease is also known as M pro or 3CL Pro and this protein is essential for the transcription/replication of the RNA ...that protease inhibitors ...
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Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M pro ) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study
... cells. Main protease (M pro /3CL pro ) is a key enzyme for coronavirus replication [69], and surface Spike (S) glycoprotein (S protein) is an essential binding protein for the fusion of the virus and ...
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Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat`s claw) against the Main Protease 3CL Pro of SARS-CoV-2 by Molecular Modeling
... All the Molecular Dynamics (MD) simulations were carried out using the dimeric structure of COVID main protease available in the PDB [40] (code 6lu7) as receptor. The best-scored docking positions were used ...
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Potential inhibitors of SARS-CoV-2 Main protease (M pro ) identified from the library of FDA approved drugs using molecular docking studies
... Corona Virus Infectious Disease-2019 (COVID-19) outbreak originated recently at Wuhan, China in December 2019. It has already spread rapidly to more than 200 countries and has been declared a pandemic by WHO. It is ...
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Without Its N-Finger, the Main Protease of Severe Acute Respiratory Syndrome Coronavirus Can Form a Novel Dimer through Its C-Terminal Domain
... The main protease (M pro ) of severe acute respiratory syndrome coronavirus (SARS-CoV) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is ...
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Anti-COVID-19 Effects of Ten Structurally Different Hydrolysable Tannins through Binding with the Catalytic-Closed Sites of COVID-19 Main Protease: An In-Silico Approach
... viral main protease (3-chymotrypsin-like cysteine enzyme) controls COVID-19 duplication and manages its life cycle, making it a drug discovery ...the main protease of 2019-nCoV using molecular ...
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An insilico study to identify hidden features of Spike protein and Main protease of SARS-Cov2
... these main structural proteins the virus also encodes for other accessory proteins of which chymotrypsin-like protease (3 CL protease) or the main protease in important for the ...
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Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
... CoV main protease (M pro ), which is a key enzyme in viral replication via the proteolytic processing of the replicase polyproteins, has been recognized as an attractive target for rational drug ...
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Virtual screening of potential inhibitors for SARS-CoV-2 main protease
... Coronavirus Disease 2019 (Covid-19) was first described in December 2019 in Wuhan, Hubei Province, China; and produced by a novel coronavirus designed as the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ...
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Screening of FDA Approved Drugs Against COVID-19 Main Protease: Coronavirus Disease
... In the end of December 2019, a new strain of coronavirus was identified in the Wuhan city of Hubei province in China. Within a shorter period of time, an unprecedented outbreak of this strain was witnessed over the ...
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Potential Inhibitor of COVID-19 Main Protease (M pro from Several Medicinal Plant Compounds by Molecular Docking Study
... the protease inhibitor lopinavir/ritonavir, which is commonly used to treat human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome patients, for the treatment of COVID-19-infected patients ...
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Virtual Screening of Approved Clinic Drugs with Main Protease (3CLpro) Reveals Potential Inhibitory Effects on SARS-CoV-2
... Among protease inhibitors, Telaprevir, Atazanavir, Darunavir, Nelfinavir, and Fosamprenavir were also selected to be candidates. However, their predicted binding power was weaker than that of the Lopinavir. ...
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Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93
... Members of the Enterovirus genus of the Picornaviridae family are abundant, with common human pathogens that belong to the rhinovirus (HRV) and enterovirus (EV) species, including diverse echo-, coxsackie- and ...
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