Major histocompatibility antigen class 1
Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... downregulate class I major histocompatibility complex (MHC) and CD4 expression on the cell surface and to alter T-cell-receptor-initiat- ed signal transduction in T ...downregulate class I MHC ...
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Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.
... down-regulate antigen pre- ...MHC class I heavy chains are rapidly degraded, prior to their maturation, in HCMV-infected cells (3, 5, 52, ...of class I heavy chains in the ER and inhibition of ...
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Equus caballus Major Histocompatibility Complex Class I Is an Entry Receptor for Equine Herpesvirus Type 1
... retrovirus construct. As shown in Fig. 3, PCR products were obtained from the genomic DNA of the selected EHV-1-sus- ceptible B78H1 cells but not from the parental EHV-1-resis- tant B78H1 control cells ...
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Adaptor Protein 1 Promotes Cross-Presentation through the Same Tyrosine Signal in Major Histocompatibility Complex Class I as That Targeted by HIV-1
... normal antigen presentation and send MHC-I to lysosomes, we propose that the natural interaction of AP-1 in APCs ultimately sends MHC-I molecules loaded with exogenous antigen back to the cell ...in ...
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... observed that these MHC-I molecules lack peptide, and it was suggested that ICP47 somehow blocks the translocation of peptides into the ER (83), and later, TAP was identified by immunoprecipitation as the ICP47 target ...
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Accurate prediction of major histocompatibility complex class II epitopes by sparse representation via ℓ 1-minimization
... The major histocompatibility complex (MHC) is responsible for presenting antigens (epitopes) on the surface of antigen-presenting cells ...MHC class II on an APC surface, T cells may be able ...
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Inhibition of Major Histocompatibility Complex Class I Antigen Presentation in Pig and Primate Cells by Herpes Simplex Virus Type 1 and 2 ICP47
... Both ICP47-1 and ICP47-2 inhibited TAP in monkey cells (fibroblasts from rhesus macaques and chimpanzees and OMK cells). Inhibition of the rhesus macaque and owl monkey TAP required concentrations approximately ...
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Mycobacterium tuberculosis Promotes HIV trans-Infection and Suppresses Major Histocompatibility Complex Class II Antigen Processing by Dendritic Cells
... between 1 and 10 CFU of myco- bacterium per DC was required to enhance HIV trans-infec- ...of antigen presentation combined with an increased HIV trans-infection could contribute to the loss of immune ...
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Antigen Targeting to Major Histocompatibility Complex Class II with Streptococcal Mitogenic Exotoxin Z-2 M1, a Superantigen-Based Vaccine Carrier
... with 1 to 10 g M1 conjugated to ovalbumin (M1-ovalbumin) resulted in more rapid and quantitatively higher levels of anti-ovalbumin IgG, with endpoint titers being 1,000- to 10,000-fold greater than those in ...
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Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1.
... that antigen-primed PBMC collected from EHV-1- immune horses and restimulated in vitro with live EHV-1 are able to present viral antigenic peptides in association with MHC class I molecules to ...
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Modulation of Major Histocompatibility Class II Protein Expression by Varicella-Zoster Virus
... MHC class II gene expression, we found that VZV infection inhibits IFN-␥-dependent transcription of the MHC class II DR-␣ ...MHC class II expression at the level of transcription (26, ...MHC ...
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Control of major histocompatibility Class I antigen expression in adenovirus transformed cells
... PRDII-BF1 (Fan and Maniatis, 1990), HIV-EP1 (Maekawa et al., 1989) and MBP-1 (Baldwin et al., 1990) are all clones from human cDNA libraries. All three clones are thought to cover different amounts of sequence ...
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Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease
... that class I major his- tocompatibility complex (MHC-I) antigen can be variably down-regulated in RRP (1), which is consistent with reports of MHC-I antigen down-regulation in cervical ...
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Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.
... FIG. 1. Comparison of the deduced amino acid sequences of the HBsAg group a determinant (amino acids 124 to 148) between HBV consensus and naturally occurring mutants in hepatomas. The conformation of the group a ...
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Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production
... as major histocompatibility complex (MHC) class I-bound ligands at the cell surface of anti- gen presenting ...MHC class I ligand pro- duction, whereas protein turnover and cellular prolifer- ...
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Multiple sclerosis: major histocompatibility complexity and antigen presentation
... the major histo compatibility complex (MHC) was found in the 1970s, notably involving the class II human leukocyte antigen HLADR2 ...serological antigen (called an allelotype) while the ...
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Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation
... HLA class II downregulation in context. The gene products mentioned may represent just the tip of the iceberg that con- stitutes the array of herpesvirus gene products with significant effects on the immune ...
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Impact of Endogenous Intronic Retroviruses on Major Histocompatibility Complex Class II Diversity and Stability
... (Table 1). Additionally, the sim score for the full-length align- ment of HERV-K14I in HLA-DRB7 compared to that in Patr- DRB7 is 0.988 (Table 2). This score is 5.6% higher than that for the HERVK3I sequences of ...
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Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor.
... Second, SV40 does not bind to cells of two different human lymphoblastoid cell lines which do not express surface class I MHC proteins because of genetic defects in the 132-microglobulin[r] ...
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MHC (MAJOR HISTOCOMPATIBILITY COMPLEX)
... MHC class II molecules comprise two non-identical and non-covalently associated polypeptide chains (α and β). These two chains have amino ends on the surface, a short transmembrane stretch and intracytoplasmic ...
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