malaria vaccine
Community perceptions of a malaria vaccine in the Kintampo districts of Ghana
... the vaccine could be con- taminated with anti-fertility, HIV and cancerous ...a malaria vaccine were virtually unknown in the study area, not even among religious ...as malaria vaccines, since ...
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Advances and challenges in malaria vaccine development
... effective malaria vaccine would be a valuable tool to reduce the disease burden and could contribute to elimination of malaria in some regions of the ...Current malaria vaccine ...
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Awareness, perceptions and intent to comply with the prospective malaria vaccine in parts of South Eastern Nigeria
... the malaria vaccine when ...the malaria vac- cine implementation programme in the ...about malaria could have contributed to this ...other malaria endemic area to assess their level of ...
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Stakeholders’ opinions and questions regarding the anticipated malaria vaccine in Tanzania
... Forty six IDIs and 12 FGDs were conducted. The IDI par- ticipants comprised of primary school teachers, religious leaders, community health workers, health care profes- sionals, and scientists. The scientists who ...
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Adjuvants in malaria vaccine development strategies: a review
... malarial antigens or co-expressed on a separate vector and co-injected with the vaccine [49] . This method provides adjuvant activity at the site of antigen production with long-lasting effect from transfected ...
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Policy analysis for deciding on a malaria vaccine RTS,S in Tanzania
... the malaria vaccine RTS,S in ...of malaria treatment policy change interventions in Tanzania was ...and Vaccine Development (IVD) is the key actor as malaria vaccine is expected ...
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Malaria vaccine research and development: the role of the WHO MALVAC committee
... against malaria, with emphasis on the public health needs of developing ...selected vaccine-related research and development ...global malaria vaccine forum for funding agencies, sponsors and ...
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Assessment of parental perception of malaria vaccine in Tanzania
... forthcoming malaria vaccine, willingness to use a malaria vaccine, knowledge of the benefits of vac- cinating children under five, acceptability of the mode of administering the vaccine ...
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Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine
... where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly ...Seasonal malaria chemoprevention (SMC), which involves administra‑ tion of a full course of ...
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Acceptance of a malaria vaccine by caregivers of sick children in Kenya
... to vaccine uptake in ...low vaccine uptake included very low (or very high) knowledge level regarding immunizations; negligence and/or ignorance among caregivers regarding children's vaccinations; ...
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Lack of allele specific efficacy of a bivalent AMA1 malaria vaccine
... in malaria vaccine candidate antigens through balancing selection applied by host immunity may hamper the development of effective malaria vaccines, especially those targeting highly polymorphic ...
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The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti circumsporozoite protein antibody avidity in African infants
... Nevertheless, this observation adds a new component to the search of correlates of protection and the under- standing of the immune responses elicited by pre- erythrocytic malaria vaccine candidates such as ...
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Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso
... major malaria vaccine candidate antigens (GLURP and MSP3) stimulate produc- tion of specific cytophilic antibodies that are significant predictors of protection against clinical ...candidate vaccine ...
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Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria
... between vaccine candi- ...first malaria vaccine is licensed, after which placebo-con- trolled trials will likely be impossible and Phase IIb and III trials will be designed to compare between two ...
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Large screen approaches to identify novel malaria vaccine candidates
... Human Malaria Infection, CHMI), the antibody profile in the protected subjects did not significantly change, indicating that immunization pro- duced a sterilizing infection-blocking immune response (supported by PCR ...
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Prime boost strategies for malaria vaccine development
... the malaria epitope(s) of ...ME-TRAP malaria insert seven days after various DNA and/or MVA vaccination ...the vaccine insert, from the T9/96 strain of TRAP encoded in the vaccine and from ...
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Stable malaria incidence despite scaling up control strategies in a malaria vaccine testing site in Mali
... of malaria, along with study investigators long experience in the site and good rapport with the population, provided confi- dence that the follow-up procedures captured all clinical malaria episodes that ...
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Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission blocking vaccine candidates
... The ability to elicit functional transmission blocking antibodies is the most important characteristic of any protein preparation to be considered for the generation of a vaccine. Given that P. falciparum ...
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Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection
... The life cycle of the parasite has added complexity to the de- velopment of a malaria vaccine. However, shared antigenic targets (54, 55) between different life cycle stages may allow for the in- duction of ...
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Genetic diversity of the merozoite surface protein 3 gene in Plasmodium falciparum populations in Thailand
... MSP-3/LPS vaccine is a long synthetic peptide, consisting of the C-terminal portion (corresponding to amino acid positions 154–249) of ...The vaccine was shown to be safe, immunogenic and capable of ...
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