mammary development
Emerging evidence of the physiological role of hypoxia in mammary development and lactation
... including mammary development and lactation. The mammary gland exhibits an increasing metabolic rate from pregnancy to lactation to support mammary growth, lactogenesis, and ...promotes ...
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Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland
... impairs mammary development and lactogenesis in murine mammary ...to mammary gland ...alveolar development of the mammary gland, which may partially explain the delay in ...
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Patterns of cell signaling pathway activation that characterize mammary development
... Given the STAT3 and p63 results, we then examined the activation state for a number of additional cell signaling pathways (Bild et al., 2006; Black et al., 2003; Huang et al., 2003). This analysis revealed a number of ...
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Targeted activation of β catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia
... mouse mammary epithelium harbors long-lived, bipotent and lineage-restricted progenitors with a high proliferative potential (Smalley and Ashworth, 2003; Smith and Boulanger, ...early mammary progenitors in ...
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Tumour stromal interactions: Role of the stroma in mammary development
... Mammary development depends on branching morphogenesis, namely the bifurcation and extension of ductal growth points (end buds) and secretory lobules into a more or less fatty ...ductal development ...
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Gli3 mediated repression of Hedgehog targets is required for normal mammary development
... embryonic mammary development, our results provide new insight into the role of the Hh pathway during adolescent and adult mammary gland ...virgin mammary ducts is entirely consistent with a ...
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CCAAT/enhancer binding proteins in normal mammary development and breast cancer
... No mammary gland abnormalities have been reported for these double knockout mice, and it is unknown whether the gland has been analyzed for defects in ...mouse mammary gland tumors The expression profile of ...
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Mammary development in the embryo and adult: a journey of morphogenesis and commitment
... mouse mammary epithelium during pregnancy results in the expression and accumulation of p63 (also known as TRP63 – Mouse Genome Informatics) in luminal cells, suppressing their luminal characteristics and inducing ...
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The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis
... the mammary microenvironment during pregnancy as well as the microenvironment of the adipose tissue associated with obesity reveals similarities that may account for these parallels (Table ...the mammary ...
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Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis
... of mammary epithelial differen- tiation, proliferation and carcinogenesis has been widely investi- gated, many questions remain unexplored (Brennan et ...influence mammary stromal biology with regard to the ...
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Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
... placode development, we used whole-mount in-situ hybridization to examine the expression of β-catenin, Wnt10b (Christiansen et ...the mammary region of Dkk1-expressing embryos ...of mammary-specific ...
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Mammary gland development: cell fate specification, stem cells and the microenvironment
... malignant mammary glands (Barcellos-Hoff et ...in mammary development were hampered due to the lethality of this gene ...sorting mammary epithelial cells to points of branching, thus ...
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Effects of BRCA1 Transgene Expression on Murine Mammary Gland Development and Mutagen-Induced Mammary Neoplasia
... murine mammary gland as a model ...mouse mammary tumor virus (MMTV) LTR, during ductal and alveolar ...The mammary gland phenotypes of these animals were characterized to provide insights into the ...
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Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
... during development and pregnancy, indicating epithelial synthesis of CSF-1 ...However, mammary transplanta- tion experiments indicated that this CSF-1 synthesis was not necessary for macrophage recruitment ...
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Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland
... developing mammary line [7]. FGFR2b is expressed within the mammary epithelial placodes, although it has not been identified specifically within the mammary line ...the mammary line and ...
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Key signaling nodes in mammary gland development and cancer: β catenin
... adult mammary development, its proto-oncogenic properties may be viewed as arising from unbridled stem and early progenitor ...induce mammary tumors – and, subsequently, transgenic expression of ...
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Homeobox genes in mammary gland development and neoplasia
... of mammary development and neoplastic ...in mammary gland develop- ment and neoplasia will be an exceptional ...the mammary gland has several advantages over many other developmental models ...
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Key stages in mammary gland development: The mammary end bud as a motile organ
... the development of the mammary ductal tree presents fascinating and challenging problems to the developmental ...human mammary cancers are ductal in origin. The mammary end bud is the icon of ...
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Insulin like growth factor binding proteins and mammary gland development
... the mammary gland and mammary IGFBP-5 mRNA expression is decreased in CAATT-enhancer binding protein- b _ko mice, which exhibit increased expression of the prolactin ...of mammary epithelial cells, ...
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Key stages in mammary gland development Secretory activation in the mammary gland: it's not just about milk protein synthesis!
... the mammary gland from glucose and, probably, amino acid ...in mammary gene expression during secretory differentiation and activation in some detail ...the mammary gland rapidly undergoes involution ...
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