Mammary epithelium
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
... of mammary gland development (reviewed in ...Similarly, mammary epithelium does not form in the absence of the prolactin receptor, the transcription factor C/EBPβ, the transcription factors Stat5a ...
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Transduction of the Mammary Epithelium with Adenovirus Vectors In Vivo
... The mammary gland is a compound lobulotubular structure that is a reliable model for developmental studies of cellular growth and differentiation, epithelium-stroma interactions, and tissue-level analysis ...
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Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium
... mammary epithelium turned up two interesting differences between the Stat3 expressing and nonexpressing ...the mammary cells seems pro- tective against apoptosis at this ...of mammary ...
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Key signalling nodes in mammary gland development and cancer Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts
... alveolar mammary epithelium during a pregnancy ...in mammary epithelium and resulted, not surprisingly, in a reciprocal ...PTEN-null mammary epithelial cells were hyperproliferative, ...
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Hormone sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium
... Mammary epithelium consists of an outer basal layer of mainly contractile myoepithelial cells and an inner luminal layer that contains both steroid-receptor-positive cells and steroid-receptor-negative ...
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Rho Family GTPases Regulate Mammary Epithelium Cell Growth and Metastasis Through Distinguishable Pathways
... T47D mammary epithelial cells, activated Rac1 and Cdc42, but not RhoA, enhanced cell migration across filters coated with collagen (12), Cellular migration through increasingly complex surfaces such as a three ...
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Regulation and functional analysis of EphA2 in normal and Ras-transformed mammary epithelium
... vivo mammary gland tumourigenesis and an in vitro cell culture ...Ras-mediated mammary tumourigenesis using the WAPra^ model and an additional transgenic line containing the ecU ...
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High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium
... the epithelium in HMD exhibited increased numbers of vimentin + immune cell infiltration, whereas the stromal area in HMD had reduced numbers of alternatively acti- vated macrophages, suggesting an altered balance ...
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Overexpression of ERBB4 JM a CYT 1 and CYT 2 isoforms in transgenic mice reveals isoform specific roles in mammary gland development and carcinogenesis
... the mammary gland involves ductal and secretory phases that are regulated by con- certed interplay of systemic hormones, locally secreted growth factors, and their receptors – including the EGFR family, which ...
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Estrogen and progesterone induce persistent increases in p53 dependent apoptosis and suppress mammary tumors in BALB/c Trp53+/ mice
... the mammary epithelium are enhanced by hormonal ...then mammary glands were allowed to involute for 4 weeks post-weaning to produce parous ...+ mammary epithelial cells in the E+P-treated ...
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Innate defense capability of challenged primary bovine mammary epithelial cells after an induced negative energy balance in vivo
... the mammary gland. After entering the teat canal, mammary epithelium is the first line of defense against a pathogen ...the mammary epithelium, primary bovine mammary epithelial ...
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p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling
... of mammary gland development occurs postnatally under the control of female reproductive ...postnatal mammary epithelium is organized as a bilayer, with a basal layer of myoepithe- lial cells and a ...
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CCL2 driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model
... Population studies support the notion that increased CCL2 expression increases breast cancer risk and cancer progression. The risk of developing metastasis is signifi- cantly increased in patients with breast cancer who ...
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Progesterone receptors animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
... human mammary epithelium, suggesting that the ovarian steroids oestradiol and progesterone control pro- liferation and development of the mammary gland indi- rectly via the secretion of paracrine ...
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β Catenin: a transforming actor on many stages
... been inactivated specifically in mammary epithelium using the Cre-loxP recombination system [22]. Exon 14 of the Apc gene was deleted by a Cre transgene under the control of the ovine β-lactoglobulin gene ...
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Key stages in mammary gland development: The mammary end bud as a motile organ
... (ERKO) mammary epithelium with wild-type mammary stroma and discovered that stromal, not epithelial, estrogen receptors were necessary for ductal development; estrogen therefore stimulated ductal ...
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Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis
... to mammary epithelium in vivo results in a significant increase in mammary cancer ...persistent mammary hyperplasia and an increased incidence of mammary tumors in a background of ...
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Ingestion and killing of Listeria monocytogenes by blood and milk phagocytes from mastitic and normal cattle
... monocytogenes 3, 7, 22, 29, 34 and the phagocytic ability of the bovine mammary epithelium 5 suggest that invasion of mammary epithelial cells by listeriae may play some part in the path[r] ...
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New insights into lineage restriction of mammary gland epithelium using parity identified mammary epithelial cells
... At 3 days post-partum, virtually every alveolus contained only YFP-expressing cells (Figure 2C, see also Additional file 5C), consistent with complete recombination of the Rosa-lsl-YFP locus at this stage and ...
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Key stages in mammary gland development The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
... the mammary gland at pregnancy demonstrated a critical role for this receptor during alveolar morphogenesis ...in mammary epithelium lacking ErbB4, resulting in incomplete alveolar development and ...
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