Mammary Tumour
Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progression
... in mammary gland whole mounts from 100% (19/19) of animals following two weeks of doxycycline administration (Additional file 2: Figure ...of mammary gland sections at this time- point revealed that the ...
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Immunolocalization and Cellular Expression af Key Abc Transporter Proteins and Their Correlation with the Grades and Subtypes of Canine Mammary Tumour
... Canine mammary tumour (CMT) is the second most common neoplasm after skin tumours [1-4], and nearly half of them are malignant ...canine mammary gland tumors as well as human breast cancer is very ...
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Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo
... ErbB2 mammary tumour progression, we initially interbred the MMTV- activated ErbB2 strain (NDL2-5) [20] with separate strains of mice bearing MMTV-Cre and conditional FAK alleles ...in mammary ...
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Effects of curcumin in combination with cyclophosphamide on canine mammary tumour cell lines
... canine mammary cancer, we studied its effects on the proliferation, apoptosis and cell cycle progression of the cultured canine mammary tumour cell lines CMT-U27 and ...for mammary cancer in ...
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A Combination of Antigen Retrieval Methods Significantly Enhances the Unmasking of Tedious Antigens of Lymphangiogenesis and Angiogenesis in Canine Mammary Tumour
... canine mammary tumour (CMT) using recently identified ...canine mammary tumour sections resulted in efficient unmasking of epitopes when compared with the individual antigen retrieval ...
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Mouse mammary tumour virus (MMTV) and human breast cancer with neuroendocrine differentiation
... The outcomes are presented in Table 1 and Additional file 1: Table S1, Additional file 2: Table S2 and Additional file 3: Table S3. The expression of synaptophysin and chromo- granin in MMTV positive mouse mammary ...
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Mammary tumour development is dose-dependently inhibited by n-3 polyunsaturated fatty acids in the MMTV-neu(ndl)-YD5 transgenic mouse model
... mice [14,15]. Yee et al. (2005) fed mice either an 11% (w/w) corn oil diet (enriched in n-6 PUFA) or a 10% (w/w) menhaden fish oil diet beginning at 7–8 weeks of age for the duration of a 61 week study [15]. The study ...
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Sialylation regulates galectin 3/ligand interplay during mammary tumour progression a case of targeted uncloaking
... normal mammary tissue, benign and malignant tumours and although no statistical differences were found between the levels of expression of the receptor between non-tumorous tissues and CMMT (Rutteman et ...
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Involvement of α6β4integrin in the mechanisms that regulate breast cancer progression
... as c-met (a hepatocyte growth factor receptor) to promote invasion [40]. Stimulation with hepatocyte growth factor (c-met kinase) transphosphorylates β 4 , which associates with Shc and PI3K, potentiating hepatocyte ...
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Tyrosine kinase signalling in breast cancer: Tyrosine kinase mediated signal transduction in transgenic mouse models of human breast cancer
... studies. Mammary epithelial expression of mutant PyV mT decoupled from the PI-3K pathway results in the induction of extensive mammary epithelial hyperplasias ...these mammary epithelial hyperplasias ...
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The Role of Heat Shock Proteins in Mammary Neoplasms: A Brief Review
... own tumour using tumour-derived HSPs (mainly gp96, HSP70, HSP90 and calreticulin) covalently binding to specific tumour pep- ...tides—i.e. tumour antigen mucin (MUC1) derived pep- tides ...
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Öztürk-Winder, Feride (2002): Development of a gene therapy approach for the treatment of human mammary carcinoma using tissue specific retroviral vectors. Dissertation, LMU München: Fakultät für Biologie
... mouse mammary tumour virus (MMTV) promoter may be considered as is regulated by glucocorticoids hormones and its inducibility with reporter genes has already been shown (Salmons et ...
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Familial incidence of mammary gland tumours in the Djungarian hamster (Phodopus sungaros): a case report
... Kondo et al. (2008a) showed that integumental neoplasms in Djungarian hamsters were the most frequent tumours and that various types of neo- plasms were present. The most common integu- mental neoplasms were ...
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MicroRNA profiling of the pubertal mouse mammary gland identifies miR 184 as a candidate breast tumour suppressor gene
... mouse mammary tumour virus; mRNA: messenger RNA; mTORC1: mechanistic target of rapamycin complex; NOD: non-obese diabetic; ORF: open reading frame; PBS: phosphate-buffered saline; PCR: polymerase chain ...
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Expression of matrix metalloproteinase 2 (MMP-2), E-cadherin and Ki-67 in metastatic and non-metastatic canine mammary carcinomas
... a tumour cell from the primary ...the tumour and may support metastasis ...murine mammary tumour cell line with E-cadherin cDNA de- creases its invasiveness ...
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Tumour stromal interactions Reciprocal regulation of extracellular matrix proteins and ovarian steroid activity in the mammary gland
... neoplastic mammary gland. This review focuses on the interactions among mammary stroma-derived extracellular matrix (ECM) proteins, integrins and ovarian hormone-dependent proliferation in normal and ...
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Lung flooding enables efficient lung sonography and tumour imaging in human ex vivo and porcine in vivo lung cancer model
... In cases of inoperable primary or metastatic liver tu- mours, radiofrequency or microwave ablation are ac- cepted therapeutic options [1-3]. As a less invasive therapy, ablation can be performed under percutaneous, ...
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Ultrasound imaging of the lactating breast: methodology and application
... can be identified merging with the main duct. Duct diam- eters above two to three millimetres are considered enlarged and indicative of ductal ectasia [26,27] or may be related to mastalgia [28], however a range of duct ...
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Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias
... Loss of the STAT1 downstream transcription factor IRF1 has been reported in MIN cases of human breast cancer [21]. Moreover, the loss of heterozygosity at the IRF1 gene locus has been found to be a frequent event in ...
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Neuropilin 2 promotes branching morphogenesis in the mouse mammary gland
... the mammary gland requires systemic hormones and local growth factors to induce ductal outgrowth and branching (Cowin and Wysolmerski, ...the mammary gland. To investigate the role of NRP2 in pubertal ...
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