Mannose binding lectin (MBL)
A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms
... Mannose-binding lectin (MBL; also known as mannose- binding or mannan-binding protein [MBP]) is a Ca 2⫹ -depen- dent (C-type) serum lectin that plays an important role in ...
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Association of mannose binding lectin 2 genotype and serum levels with prognosis of sepsis
... Severe sepsis and septic shock cause 30% to 50% of all deaths in intensive care units (ICUs) [1]. Numerous studies have suggested that individuals vary in their ability to resist infection [2-4]. Genetic variations, such ...
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Mannose-Binding Lectin Deficiency Facilitates Abdominal Candida Infections in Patients with Secondary Peritonitis
... Mannose-binding lectin (MBL) deficiency due to variations in the MBL gene is associated with increased susceptibility to infections. In this study, the association between MBL deficiency and the ...
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Strong predictive value of mannose binding lectin levels for cardiovascular risk of hemodialysis patients
... of mannose‑binding lectin, properdin, C3d and C5b‑9 before, after and relative change during ...plasma mannose‑binding lectin (MBL) (a), properdin (c), C3d (e) and sC5b‑9 (g) ...
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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity
... [9]. Mannose binding lectin (MBL) is an essential component of innate immunity that recognizes carbohydrate residues on the surface of micro-organisms, namely, bacteria, viruses, fungi, and protozoa, ...
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Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever
... One of the major pathways of complement activation is initiated by binding of the virus to mannose binding lectin (MBL). MBL is a pattern recognition molecule that recognizes specific sugar ...
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Original Article Identification of mannose-binding lectin as a mechanism in progressive immunoglobulin A nephropathy
... Abstract: Immunoglobulin A nephropathy (IgAN), the pathogenesis of which remained still unclear is one of the lead- ing courses of end-stage renal disease in approximately 50% affected patients. On the basis of several ...
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Association of mannose binding lectin gene polymorphisms with the development of pulmonary tuberculosis in China
... [2]. Mannose-binding lectin (MBL) is an acute-phase serum protein in the collection family that recognizes a pathogen by its carbohydrate recog- nition ...
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Deficiency of functional mannose binding lectin is not associated with infections in patients with systemic lupus erythematosus
... the lectin pathway of complement activation has also been suggested to play a role in the occurrence of infections in ...for mannose-binding lectin (MBL) variant alleles were at an increased ...
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Original Article Serum mannose-binding lectin levels in patients with ischemic stroke
... Abstract: Background: The purpose of this study was to investigate the serum levels of mannose-binding lectin (MBL) in the Chinese patients with acute ischemic stroke (AIS). Method: We conducted a ...
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Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection
... Mannose binding lectin (MBL) plays a central role in the innate immune response (32). mbl2, which encodes MBL, is located on chromosome 10 and consists of four exons (Fig. 1). Several ...
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Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease
... ment. Mannose-binding lectin binds to the surface of the pathogen and has a major role in the innate im- mune response through the ability to increase op- sonization pathogens and activating the ...
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Association of Mannose-Binding Lectin Gene Polymorphism but Not of Mannose-Binding Serine Protease 2 with Chronic Severe Aortic Regurgitation of Rheumatic Etiology
... to mannose-binding lectin (MBL) (27) encoded by the MBL2 gene in the chromosome region ...C-type lectin and a member of the collectin family, is a soluble pattern recognition receptor and ...
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Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose binding lectin
... Mannose-binding lectin (MBL), a mammalian le- ctin, is a pattern recognition molecule of the in- nate immune system and recognizes carbohy- drates that are exposed on ...the lectin complement ...
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The pandemic (H1N1) 2009 influenza virus is resistant to mannose binding lectin
... defense. Consequently, the susceptibility of a pathogen to an innate immune response inevitably determines its pathogenesis. Human seasonal influenza A viruses are susceptible to mannan-binding protein, also known ...
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Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation
... If mannose binding lectin is an active participant in lung allograft injury at the initi- ation of ischemia reperfusion through the continuum of acute and chronic lung allograft rejection, current ...
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Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study
... Pattern recognition receptors (PRR) are crucially involved in the initial and immediate immune response against S. aureus (reviewed in [9]). In particular, nucleotide-binding oligomerization domain 2 (NOD2) and ...
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Mannose binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis
... factor mannose-binding lectin (MBL) are associated with a favourable disease course of RA by facilitating the clearance of pathogenic immunoglobulin G (IgG) lacking galactose sugar ...
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Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study
... of binding to the cell surfaces of invasive pathogens, thereby stimu- lating a downstream immune ...where binding of MBL has been shown to be low ...Serum Mannose-Binding Lectin ...
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Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review
... Mannose-binding lectin (MBL) and the Mannose-binding lectin-associated serine proteases (MASPs) are an essential aspect of innate immune responses that probably play an important ...
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