MAPK inhibitors
The c-Jun/RHOB/AKT pathway confers resistance of BRAF -mutant melanoma cells to MAPK inhibitors
... To determine the role of RHOB in the cellular response to MAPK inhibitors, RHOB expression was prevented by RNA interference (Figure S3A). Following RHOB depletion, the IC50 of PLX4032 was significantly ...
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Molecular insights on potential combination of MAPK inhibitors together with HCQ and HCQs analogs in viral infection
... the MAPK cascade, which, in turn, is a key pathway in regulating different steps of viral replication, transport, translation, capsid assembly, and spreading, may be affected at some levels by CQ and HCQ ...
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Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
... approach is not curative, as some BRAF-mutated melanoma cells are intrinsically resistant to MAPK inhibitors (MAPKi). At the systemic level, our knowledge of how signaling pathways underlie drug resistance ...
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Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors
... BRAF inhibitors deeply alter the metabolism of melanoma cells. On the one hand, vemurafenib suppresses glucose uptake and glycolysis long before the onset of tumor growth arrest and cell death [5]. On the other ...
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The density and spatial tissue distribution of CD8+ and CD163+ immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors
... in the peritumoral CD163 + macrophages. Thus, both the density and distribution of CD163 + macrophages seem to determine the biological and clinical events associated with ORR. One of th[r] ...
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Small molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation
... the MAPK signaling pathway to attempt to reverse the biological consequences of oncogenic BRAF ...RAF inhibitors, it is not suf- ficient merely to inhibit the MAPK pathway, but that it needs to be ...
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Adenovirus Induction of IRF3 Occurs through a Binary Trigger Targeting Jun N-Terminal Kinase and TBK1 Kinase Cascades and Type I Interferon Autocrine Signaling
... kinase inhibitors may be indirectly influencing the level of IRF3 phosphorylation by compromising cell viability or virus uptake, macrophages were pretreated with MAPK inhibitors or wortmannin and ...
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Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B
... p38 MAPK inhibitors and NF-kappa B ...p38 MAPK and NF-kappa B is involved in the regulation of COX-2 and PGE2 in NTHi-infected lung ...p38 MAPK on the activation of NF-kappa ...p38 MAPK ...
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Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia
... gen recognition by the TCR and additional signals (collectively called costimulatory signals), delivered by the same antigen-presenting cell [34]. In the absence of costimulation, lymphocytes fail to respond effectively ...
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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.
... p38 MAPK inhibitors (VX745 and SCIO469), specific inhibitors of PI3K α (NVS-P13K-2), δ (NVS-P13K-3) or γ (NVS-P13K-5) and a ROCK inhibitor PF4950834 on macrophage phagocytosis, early intracellular ...
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XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell
... EGFR overexpression [35], a possible association of XIAP with EGFR overexpression has never been explored in previous studies. We demonstrate here that XIAP is a strong positive regulator of EGFR expression in human ...
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Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors
... Benzothiophenes are naturally-occurring heterocycles, found in petroleum deposits in their simplest form but also discov- ered recently as a motif in more complex glycosides isolated from the roots of E. grijissii. 1 ...
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Involvement of mitogen activated protein kinase kinase 6 in UV induced transcripts accumulation of genes in phytoalexin biosynthesis in rice
... of MAPK cascade in UV induced expression of genes in PA ...in inhibitors fed plants (Figure 3c) indicating involvement of MAPK cascade in UV induced PA accu- ...
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The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNF alpha
... Other forms of resistance that have been described rely on the activation of additional signaling pathways such as signaling downstream of PI3 kinase (PI3K), which can be targeted by selective inhibition (5). Another ...
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<p>Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway</p>
... have shown that HDAC6 inhibitors can inhibit the growth of colon cancer cell lines (HCT116, HT29, Caco-2). 10,11,13,25,26 However, more recent research reported that a HDAC inhibitor (TriA) showed no effect on ...
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Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava
... Diabetic patients form a major subgroup of patients undergoing cardiovascular interventional procedures. Compared to non-diabetics, diabetics show a higher inci- dence of vein graft neointimal hyperplasia along with sig- ...
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Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
... not MAPK, abolishes the neuronal hyper- polarization induced by ...PI3K inhibitors would sug- gest that this enzyme is central to insulin-induced ...PI3K inhibitors, contributes to the thermogenic ...
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Activation of the Saccharomyces cerevisiae Filamentation/Invasion Pathway by Osmotic Stress in High-Osmolarity Glycogen Pathway Mutants
... a MAPK cascade mutant by the overexpression of a one of the two thioredoxin genes in yeast (Gan ...1991). MAPK phosphatase was intriguing, so MSG5 was selected After obtaining TRX1 in the suppressor screen, ...
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Activation of PPAR gsuppresses proliferation and induces apoptosis of esophageal cancer cells by inhibiting TLR4- dependent MAPK pathway
... suppressed MAPK activity and overcame resistance, highlighting the critical dependence of BRAF-mutant colorectal cancers on the MAPK pathway and pointing to potential strategies to overcome clinical ...
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Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila
... In this study, we show that the MAPK pathway, in response to Egfr, but not to btl, ensures the maintenance of tissue integrity during tracheal branching in a pnt-independent manner. The effects of Egfr pathway ...
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