MAPK pathway
Global Regulation of a Differentiation MAPK Pathway in Yeast
... Rim101p pathway, which are downregulated by that pathway and upregulated in that mutant (Lamb and Mitchell 2003); PHO5, which is downregulated by the Pho85p pathway and upregulated in the mutant ...
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Oncogenic AKAP9 BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
... of MAPK pathway components: through chromosomal rearrangement in patients exposed to radiation or through point mutations in patients with no radiation history (Figure ...
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ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2
... One of the major mitogenic signaling pathways activated downstream of cell stimulation by growth factors and constitutively activated in cancer cells is the RAS/ ERK (extracellular signal-regulated kinase) ...
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Original Article Neuroprotective effects of sarsasapogenin-AA13 via autophagy and MAPK pathway
... AA13 pretreatment. Since NF-κB p65 is one of the downstream transcription factors of MAPK pathway, we speculated that the protective effects of AA-13 might be related to regulation of MAPK ...
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Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
... p38 MAPK, was used to confirm the involvement of p38 MAPK pathway in deguelin-induced ...p38 MAPK pathway and inhibition of p38 MAPK could attenuate deguelin-induced ...
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Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans
... Gq-Rho pathway. Through epistasis experiments, we found that the core ERK MAPK cascade is required for Gq-Rho regulation of locomotion, but that the canonical ERK activator LET-60/Ras may not be ...ERK ...
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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low grade astrocytomas
... astrocytomas by using array-based comparative genomic hybridization. Duplication of the BRAF protooncogene was the most frequent genomic aberration, and tumors with BRAF duplication showed significantly increased mRNA ...
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TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
... of MAPK activation in TERT expression, four representative cell lines with (M74, ...the MAPK pathway in the presence of TERT promoter ...between MAPK pathway activation and TERT ...
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Essential role of the ERK/MAPK pathway in blood placental barrier formation
... ERK/MAPK pathway in blood-placental barrier ...ERK/ MAPK pathway controls the expression and activity of PPAR γ , a direct regulator of Muc1, and the cellular distribution of GLUT1, MCT1 and ...
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A proteomic analysis of the effect of mapk pathway activation on l-glutamate-induced neuronal cell death
... Abstract: Oxidative stress has been implicated in the pathogenesis of neuronal degenerative diseases. It is also widely known that oxidative stress induces mitogen-activated protein kinase (MAPK) signaling ...
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Evodiamine Induces Extrinsic Apoptosis Through P38 Mapk Pathway and Inhibits Autophagy in Gallbladder Cancer
... While the diagnostic and treatment techniques of the gallbladder carcinoma are progressing ceaselessly, there is no effective adjuvant therapy yet. Recent studies have identified that Chinese medicines play a significant ...
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Negative Functional Interaction Between Cell Integrity MAPK Pathway and Rho1 GTPase in Fission Yeast
... integrity pathway. Accordingly, elimination of Pmk1 MAPK partially rescued rho1-596 thermosensitivity, corroborating the unexpected antagonistic functional relationship of these ...integrity MAPK ...
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<p>Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells</p>
... of MAPK signaling pathways in the migra- tion and invasion of NSCLC cells and found that the levels of p-MEK and p-ERK were signi fi cantly increased after OPN overexpression, which were dramatically changeover by ...
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Dry eye management in a Sjögren’s syndrome mouse model by inhibition of p38-MAPK pathway
... The p38 mitogen-activated protein kinase (MAPK) pathway has been shown to be activated by IL-1β treat- ment in a number of cell types including lacrimal gland cells [15]. In this study, consistent with ...
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Recurrent mutations of MAPK pathway genes in multiple myeloma but not in amyloid light-chain amyloidosis
... Clinically applicable platforms revealing actionable genomic alterations may improve the treatment efficacy of myeloma patients. In this pilot study, we used a high depth targeted sequencing panel containing 83 ...
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Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia
... Deregulation of microRNAs’ expression frequently occurs in acute myeloid leukemia (AML). Lower miR-181a expression is associated with worse outcomes, but the exact mechanisms by which miR-181a mediates this effect remain ...
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Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway
... of MAPK signaling following erlotinib treatment, which was dependent on the MET receptor, contributed to the adaptive resistance of EGFR ...the MAPK pathway activation as a result of CRAF or NRAS ...
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A Non-Mendelian MAPK-Generated Hereditary Unit Controlled by a Second MAPK Pathway in Podospora anserina
... a MAPK pathway composed of the PaASK1 MAPKKK, the PaMKK1 MAPKK, and the PaMpk1 MAPK, which appears to be able to gener- ate C, a hereditary unit that has properties exhibited by ...the pathway ...
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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
... p38 MAPK pathway is required for normal skeletogenesis in mice, as mice with deletion of any of the MAPK pathway member–encoding genes MAPK kinase 3 (Mkk3), Mkk6, p38a, or p38b ...
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RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action
... KRAS was found to be a direct target of miR-200c in breast and lung cancer cell lines [71]. MiR-216b was down-regulated in nasopharyngeal carcinoma and bound KRAS mRNA 3’-UTR. MiR-216b decreased expression is directly ...
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