MAPK signaling
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
... the MAPK signaling pathway would prohibit or, at least, reduce, the observed potentiation of TKI activity by ...the MAPK pathway indeed plays a key role in mediating the antitumor effects of TKIs in ...
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Original Article TRB3 regulates pulmonary interstitial fibrosis through the MAPK signaling pathway
... fibrosis. MAPK signaling pathway plays an important role in the fibrotic processes, such as myocar- dial fibrosis [15], renal fibrosis [6], pulmonary fibrosis [16], and ...the MAPK pathway may play ...
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MAPK signaling is necessary for neurogenesis in Nematostella vectensis
... FGF signaling may be responsible for neural induction, be- cause FGF is a positive regulator of neural induction during vertebrate development [15] and MEK activity has been described to be downstream of FGF ...
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Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection
... sensing signaling cascade, suggesting that PGC-1 control of energy homeostasis and nutritional status are conserved from insects to mammals ...factor signaling (IIS)-dependent mitochondrial biogenesis with ...
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Crucial requirement of ERK/MAPK signaling in respiratory tract development
... of ERK/MAPK signaling on Sox9 expression. This reduction in gene dosage might be sufficient to perturb cartilage formation, as Sox9 +/− embryos die perinatally with severe cartilage hypoplasia (Bi et al., ...
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Heracleum moellendorffii roots inhibit the production of pro inflammatory mediators through the inhibition of NF κB and MAPK signaling, and activation of ROS/Nrf2/HO 1 signaling in LPS stimulated RAW264 7 cells
... and MAPK signaling in the inflammatory response results in excessive pro- inflammatory mediator production [11, ...and MAPK signaling has been con- sidered a major target for the development ...
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The interaction of neuroimmunology, neuromodulator, and neurotransmitter with nociceptor and MAPK signaling
... A1Rs signaling pathway will inhibit cyclic AMP/PKA and interact with the Ca+ dan K+ channel through Ga, interact with PLC/IP3/ DAG pathway through Ga subunit or bc and b-arresting mediating receptor and ...
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Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
... p38a MAPK inhibitor and a genetic approach with primary microglia that are deficient in p38a that the a isoform of p38 MAPK is critical for the production of IL-1b and TNFa from activated microglia ...p38a ...
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Schmidt, Eva Marina (2018): Therapeutic targeting of tumor cell plasticity in colorectal cancer. Dissertation, LMU München: Medizinische Fakultät
... from MAPK to NOTCH activity upon MAPK ...NOTCH signaling, we treated SW480 and PDX1 xenografts with DBZ and found complete depletion of NICD accumulation in these tumors that in time course analysis ...
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Fisetin, aphytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells
... and MAPK signaling in endothelial cells [9, ...PI3K/AKT/mTOR signaling also plays an important role in angiogenesis regulation in various cancers by increasing VEGF production in endothelial cells as ...
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Quercetin Decreases Th17 Production by Down-Regulation of MAPK- TLR4 Signaling Pathway on T Cells in Dental Pulpitis
... of MAPK sig- naling pathway. As previously mentioned, MAPK signaling pathway can activate ST2 and TLR4 signal- ing ...inhibit MAPK signaling ...
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MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population
... of MAPK signaling and inflammatory cytokine secretion and insulin resistance was also studied in skeletal muscle, adipocytes, retinal and hepatic tissues of T2DM patients and models (11, ...
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Overexpression of Toll-like Receptor 4-linked Mitogen-activated Protein Kinase Signaling Contributes to Internalization of Escherichia coli in Sheep
... downstream signaling molecules of TLR4; however, some evidence suggests that only p38 participates in bacterial internalization [12], while other studies suggest that p38, JNK, and ERK are all involved in this ...
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The role of HIFs in ischemia-reperfusion injury
... through MAPK- and mTOR-mediated control of mRNA ...kinase signaling can increase HiF expression and activity through mTOR and MAPK signaling, while both the adenosine receptors 2A/B and ...
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Hedgehog signaling stimulates the formation of proliferating Müller glia derived progenitor cells in the chick retina
... Hh signaling and FGF/MAPK signaling (Spence et ...FGF/MAPK signaling is sufficient to stimulate the formation of MGPCs in the absence of damage (Fischer et ...Hh signaling is ...
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Feedback control of the EGFR signaling gradient: superposition of domain splitting events in Drosophila oogenesis
... of MAPK signaling is split along the dorsal midline ...of MAPK signaling is not essential for specifying the two domains of BR expression and DA ...
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Gene regulatory networks and developmental plasticity in the early sea urchin embryo: alternative deployment of the skeletogenic gene regulatory network
... Wnt signaling (Logan et ...blastomeres. MAPK signaling is required for the expression of Lvalx1 and downstream skeletogenic genes in NSM cells, mirroring its role in the PMC ...
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<p>CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway</p>
... several signaling pathways as well as the related proteins involved in cell proliferation regulation was ...MEK/ERK signaling pathway was regulated by the expression of CCNY in Hep2 ...The MAPK ...
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<p>PKMYT1 Promotes Gastric Cancer Cell Proliferation and Apoptosis Resistance</p>
... such as proliferation, apoptosis, and survival. 11,12 Our previous data revealed that PKMYT1 is closely related to the cell proliferation and anti-apoptosis of GC cells. Therefore, we compared and analyzed the changes in ...
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Fullerene mediates proliferation and cardiomyogenic differentiation of adipose-derived stem cells via modulation of MAPK pathway and cardiac protein expression
... of MAPK signaling (ERK and p38) related to stem cell survival, proliferation, and car- diomyogenesis, thereby enhancing proliferative activity of ...
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