Mast cell activation
Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options
... a mast cell activation disease (Table 4) which may present mast cell mediator-induced symptoms by activation of normal mast cells ...the mast cell media- tor ...
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Mast cell activation and migration to lymph nodes during induction of an immune response in mice
... Mast cell activation has been shown previously to be a prominent feature in the elicitation phase of contact hypersen- sitivity ...to mast cell ...that mast cell ...
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The role of phospholipase A2 in mast cell activation
... on mast cell activation have been ...of mast cell activation by PLA 2 ...platelets, mast cells and inflammatory ...
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Inhibition of IgE mediated mast cell activation by the paired Ig like receptor PIR B
... antibody–mediated mast cell ...murine mast cells, a trio including Fc γ RIIB and gp49B1 (31, ...for mast cells to attenuate their release of potent inflammatory ...regard, mast cells ...
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Effect of common food additives on mast cell activation
... between mast cells and the most common additives approved for use in ...on mast cell degranulation were carried out. Rat peritoneal mast cells were incubated with: 1) buffer solution or 2) ...
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Mast cell activation enhances airway responsiveness to methacholine in the mouse
... Mast cell-deficient mutant mice and their normal littermates were used to determine whether activation of mast cells by anti-IgE enhances airway responsiveness to bronchoactive agonists in ...
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Mast cell activation in the skin of Plasmodium falciparum malaria patients
... are activated in severe P. falciparum malaria. Normally, MCs can undergo repeated rounds of degranulation and regranulation [35-38]. An in vitro human lung MC culture showed late recovery (18–48 hr) from IgE-induced MC ...
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Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity
... Palmitoylethanolamide (PEA) was initially identified from the purified lipid fractions of egg yolk [1], and later found in a wide variety of food sources [2, 3]. In addition, PEA is also considered an endogenous lipid ...
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Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion
... their activation/degranulation, especially at car- tilage erosion sites ...secretion, activation or degranu- lation in situ will bring about changes in the local environ- ment, not least the phenotype of ...
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The Cbl family of ubiquitin ligases regulates FcεRI expression and mast cell activation
... the cell-surface of mast cells, generates signals that cause a shift in the resting state equilib- rium of phosphorylation and dephosphorylation events that serves to maintain ...lating mast ...
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Particulate allergens potentiate allergic asthma in mice through sustained IgE mediated mast cell activation
... mice. Mast cells (MCs) were implicated in this divergent response, as the differences in airway inflammatory responses provoked by the physical nature of the allergens were attenuated in MC-deficient ...
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Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia
... Another focus of the current study was to prospectively evaluate global response, to determine which symptoms improve with cholecystectomy, and to evaluate whether there is a relationship between MC density or ...
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Utility of hydroxyurea in mast cell activation syndrome
... Given these new biologic and clinical insights, pro- posals have emerged to consider all MC diseases under the umbrella term of MC activation disease (MCAD) [32]. It also has been proposed that the assorted sys- ...
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Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation
... of mast cells localized in the injured nerve and DRG and the extent of their degranu- lation is ...of mast cell degranulation, we suggest a mechanism that could underscore the return to pain-like ...
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Involvement of proteases and kinases in mast cell activation
... in mast cells involves the activation o f an endogenous ...f cell stimulation, suggesting that the enzyme normally existed as a zymogen, which was converted to the active state following IgE receptor ...
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Clinical potential of midostaurin in advanced systemic mastocytosis
... non-mast cell lineage disease; ASM, aggressive systemic mastocytosis; C, clinical; G, grade; MCL, mast cell leukemia; MCS, mast cell sarcoma; mTOR, mammalian target of rapamycin; ...
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The significance of diagnosing associated clonal mast cell diseases in patients with venom-induced anaphylaxis and the role of bone marrow investigation
... monoclonal mast cell activation syndrome (MMAS) ...the mast cells clonality; which can be proven by the de- tection of a codon 816 KIT mutation and/or occurrence of immunophenotypically ...
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Perinatal stress, brain inflammation and risk of autism-Review and proposal
... perinatal mast cell activation by en- vironmental, infectious, neurohormonal and immune triggers could adversely affect neurodevelopment, dis- rupt the gut-blood–brain barriers, and contribute to ...
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Regulating Bcl2L12 expression in mast cells inhibits food allergy
... of activation on inducing mast cell apoptosis, both FA and control groups were treated with a non-specific mast cell activator, C48/80 [mouse intestinal mast cells express ...
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Mast cell tryptase regulates rat colonic myocytes through proteinase activated receptor 2
... rat cell lines (KNRK and hBRIE 380 cells) as positive controls that are known to express PAR-2, and one human cell line (A549) as a negative control that also expresses PAR-2 ...
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