MAST CELL- TRYPTASE
Mast cell tryptase is a mitogen for cultured fibroblasts
... of tryptase, suggesting, though not proving, the participation of the catalytic site in cell activation by ...that tryptase and thrombin activate distinct signal transduction pathways in ...implicate ...
8
Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs
... predominantly involving membrane potential-dependent Ca2+ transport, were also potentiated by tryptase. However, the contractile effects of acetylcholine, which contracts dog airway smooth muscle by a mechanism ...
6
Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
... stimulated mast cells, showed no differences compared to the non-stimulated mast ...of mast cell tryptase in ...with mast cells and CM could be that different factors are ...
13
Mast cell tryptase regulates rat colonic myocytes through proteinase activated receptor 2
... that mast cell tryptase potently activates PAR-2 on isolated ...Although tryptase did not inhibit motility of strips of colon, other PAR-2 agonists strongly in- hibited ...that tryptase ...
12
Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation
... https://doi.org/10.1172/JCI114344. Mast cells have been implicated in the pathogenesis of the matrix degradation observed in the cartilaginous and osseous structures of the rheumatoid ...human mast ...
7
Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease activated receptor 2 and cyclooxygenase 2
... Discussion Mast cells have been identified as an important actor in the inflammatory process following injury and allergic ...of mast cells in tissue regenera- tion through stimulation of cell ...
9
Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
... Abstract Mast cell activation is a characteristic feature of chronic in- flammation, a condition that may lead to fibrosis as a result of increased collagen synthesis by ...of tryptase, the major ...
10
Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis
... https://doi.org/10.1172/JCI114051. Tryptase, a neutral protease of human mast cells, is a potentially important indicator of mast cell involvement in various clinical ...of tryptase in ...
6
The activation of lung fibroblasts by human mast cell tryptase: A role for protease activated receptor-2 (PAR-2)
... activated mast cells that produce a range o f mediators capable of modulating fibroblast ...mediator, tryptase, is a known fibroblast mitogen and profibrotic ...that tryptase is able to activate ...
349
ImmunoCAP. Is it anaphylaxis? Tryptase
... of tryptase levels has been used over many years to confirm mast cell tryptase activation, which supports a diagnosis of ...The tryptase released on allergic activation with ...
6
Tryptase Mast Cells in Malignant Pleural Mesothelioma as an Independent Favorable Prognostic Factor
... findings, activation of MCs could result in the release of cytokines that promote the recruitment of eosinophils, neu- trophils, and other effector cells. In addition, other studies 24,25 presupposed that IL-2 ...
7
Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension*
... human tryptase II/ b, 6 surface loops are involved in the two different kinds of contacts within the tet- ...putative tryptase has structural features that allow it to interact with other ...
10
Human mast cells stimulate vascular tube formation Tryptase is a novel, potent angiogenic factor
... Matrigel without exogenous stimulation revealed that HDMEC rearranged or aligned themselves in an organized manner within 1 or 2 h of plating. By 16–18 h after plating, the tube- forming process reached a maximum. In the ...
11
Feline Mast Cell Tumours
... Visceral MCTs are more common in the cat than in the dog, with up to 50% of cases occurring in visceral sites. This may be more common in the USA than Europe, and geographical variation has not been fully explored. In ...
15
Tryptase plays a role in solid tumor angiogenesis and cell proliferation
... cancer cell proliferation (Table ...intestinal cell surfaces is also increased by tryptase activated PAR-2, thus playing a role in tumor proliferation, growth, and ...carcinoma cell lines ...
7
Expression of Mast Cell Proteases Correlates with Mast Cell Maturation and Angiogenesis during Tumor Progression
... of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeira˜o Preto – University of Sa˜o Paulo, Ribeira˜o Preto, Sa˜o Paolo, Brazil, 2 Department of Estomatology, Faculdade de ...
11
Original Article Tryptase and TIM-1 double-positive mast cells in different stages of human chronic periodontitis
... of tryptase-TIM-1 double-positive MCs and degranulation of MCs had the similar tendency as the severity of periodontitis inflammation, suggesting that tryptase-TIM-1 double-positive MCs may secrete various ...
10
CiteSeerX — Mast cell activation disease
... Mast cell activation disease Hanan Abd El Lateef Lecturer in Pediatrics, Ain Shams University, Cairo Mast cells are multifunctional cells that initiate not only IgE dependent allergic diseases but ...
9
CiteSeerX — CANINE MAST CELL TUMORS
... For tumors where complete excision is not feasible due to the extent of disease, the approach will depend on the owners treatment goals and on full staging. In these cases, full staging including an incisional biopsy to ...
6
CiteSeerX — Systemic Mast Cell Disease
... After 30 days of hospitalization, the patient had become cachectic and acutely ill. He complained of anorexia and intermittent episodes of nausea and vomiting. Recurrent, unexplained fever of 104 F was accompanied by ...
20