matrix metalloproteinase–2 (MMP2)
Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) before and after interventional therapy of ruptured intracranial aneurysm (IA), as well as their ...
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SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY
... 7. Serum matrix metalloproteinase -2 (MMP-2) levels will be assessed interictally. Five milliliters of blood was collected from the antecubital vein into vacutainer tubes without ...
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Integrin Alpha V Beta 3 Matrix Metalloproteinase 2 (MMP 2), Cross Talk
... metastasis. MMP activity is tightly regulated at several levels, from transcription, to proenzyme activation and finally by inhibition with TIMPs. Most MMPs are secreted in a proenzyme form that is later activated by ...
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Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsia
... Higher levels of MMP-2 were found in the plasma of non- pregnant patients with hypertension [16]. Several other studies have found increased plasma MMP-2 levels in women with preeclampsia [8,15]. Myers at ...
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High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... Abrogation of β 1 integrin expression suppressed Col I- induced MMP-2 activation via MT1-MMP up-regulation In MCF-7-MT1 cells, Col I caused activation of MMP- 2 despite MT1-MMP being under the control of a ...
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Modulation of monocyte matrix metalloproteinase 2 by breast adenocarcinoma cells
... ECM, especially basement membrane type IV collagen, is con- sidered a key event for tumor cell invasion and metastasis. Specifically in colorectal cancer, MMP-9 is derived principally from stromal monocytes [35,36] and a ...
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Platelet aggregation induced by Caco 2 cells: regulation by matrix metalloproteinase 2 and adenosine diphosphate
... o-phenanthroline, or APT102, which was added 2 min prior to tumor cells. When TCIPA reached 50% maximal light transmission, the reaction was terminated by 10-fold dilution with physiologic saline. Resting ...
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Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliation syndrome
... A considerable amount of MMP-2 was detected in aque- ous humor samples from both groups of patients, but the total level of MMP-2 (proenzymes and complexed forms) was not significantly different in the PEX ...
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Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma
... H 2 O 2 for 10 minutes, the sections were incubated at 4 ° C overnight with polyclonal primary antibodies (anti- MMP-2; Santa Cruz Biotechnology ...
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Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis
... Langendonckt et al. 2002; Giudice and Kao 2004). Ele- vated levels of matrix metalloproteinase-2 (MMP2) and MMP-9 have also been reported (Chung et al. 2001; Osteen et al. 2003). The treatment ...
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Aging is associated with increased activities of matrix metalloproteinase 2 and 9 in tenocytes
... MMP-3, MMP-10, MMP-12, MMP-27 and TIMP-2 in either ruptured or painful tendons [5-8,10]. However, there is currently no direct evidence of an association between age and the activities of MMPs. Gelatinases ...
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Relationship between single-nucleotide polymorphism of matrix metalloproteinase-2 gene and colorectal cancer and gastric cancer susceptibility: a meta-analysis
... SNPs affecting the gene transcription and expression are associated with malignant cancers susceptibility. SNP is the most common type of genetic variation, and genetic variation in MMP-2 may contribute to ...
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Active synovial matrix metalloproteinase 2 is associated with radiographic erosions in patients with early synovitis
... In the joint, MMP-9 is expressed in macrophages in the synovial lining layer, in vascular endothelial cells, leuko- cytes, chondrocytes, and osteoclasts. It is also expressed on cultured fibroblasts and on activated ...
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CD147 and matrix-metalloproteinase-2 expression in metastatic and non-metastatic uveal melanomas
... For CD147 and MMP-2 double-immunostainings, ser- ial paraffin sections were deparaffinized in three changes of xylol and rehydrated in a graded series of alcohol (100–50 %). Antigen retrieval was performed by ...
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Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion
... Isolation and cultivation of human cytotrophoblast cells Human trophoblast cells were obtained from legal abor- tions (6 to 12 weeks of gestational age), with the approval of the local ethical committee (in compliance ...
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Role of matrix metalloproteinase-2/9 (MMP2/9) in lead-induced changes in an in vitro blood-brain barrier model
... MMPs participate in many physiology and pathological processes in the brain and at BBB [18]. Previous research had shown that MMPs degrade TJ proteins and basement membrane proteins, although there was little data to ...
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Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
... state. Matrix metallo- proteinases (MMPs) are a group of structurally related endopeptidases that catalyze the degradation of various macromolecular components of the extracellular matrix and basement ...
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Immunohistochemical expression of Matrix Metalloproteinase-2 (MMP-2) in inguinal hernia
... The exact etiology of inguinal hernias is still being widely experimented and remains unclear. Many factors predisposing to hernias have been proposed which includes; an open processus vaginalis, increased intraabdominal ...
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The Distribution of Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-4 in Psoriatic Skin
... MMP-2 expressed in few to moderate (+/++) keratinocytes and in moderate to numerous (++/+++) dermal connective tissue cells in healthy skin (Fig. 1). In tissue samples of psoriasis patients numerous (+++) ...
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Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline
... Patients and methods: Healthy smokers with AHR (AHR + S) or smokers without AHR (AHR − S; divided according to a methacholine challenge test) and nonsmokers without AHR (AHR − NS) were enrolled. Spirometry was performed ...
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