Maturation inhibitor
The prototype HIV 1 maturation inhibitor, bevirimat, binds to the CA SP1 cleavage site in immature Gag particles
... information on the interaction of bevirimat with its tar- get. Photoaffinity labeling is a proven and powerful tool that has been extensively used to gain insight into drug- binding sites and mechanism of action. Using ...
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HIV 1 protease inhibitor mutations affect the development of HIV 1 resistance to the maturation inhibitor bevirimat
... particle maturation, the structural rearrangement required to form infectious virus ...inhibitors, maturation inhibitors impede particle maturation by targeting the substrate of protease (Gag) ...
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Structure activity relationships of the Human Immunodeficiency Virus type 1 maturation inhibitor PF 46396
... We have clearly demonstrated that two inactive analogues (StA-MAT-23 and -30) are capable of interacting with WT Gag albeit with a reduced affinity compared to PF-46396. We next sought to determine if inactive analogue ...
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Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396
... We have clearly demonstrated that two inactive analogues (StA-MAT-23 and -30) are capable of interacting with WT Gag albeit with a reduced affinity compared to PF-46396. We next sought to determine if inactive analogue ...
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In Vitro Resistance to the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PA-457 (Bevirimat)
... (HIV-1) maturation by blocking a late step in the Gag processing pathway, specifically the cleavage of SP1 from the C terminus of capsid ...the maturation of SP1 residue 3 ...
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Human Immunodeficiency Virus Type 1 Resistance to the Small Molecule Maturation Inhibitor 3-O-(3′,3′-Dimethylsuccinyl)-Betulinic Acid Is Conferred by a Variety of Single Amino Acid Substitutions at the CA-SP1 Cleavage Site in Gag
... (HIV-1) maturation inhibitor 3-O-(3 ⬘ ,3 ⬘ - dimethylsuccinyl)-betulinic acid (DSB) (alternatively referred to as YK-FH312 and PA-457) (reviewed in references 2 and ...and maturation of ...
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Impact of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Evolution of Resistance to the Maturation Inhibitor Bevirimat (PA-457)
... The maturation inhibitor bevirimat [3-O-(3 ⴕ ,3 ⴕ dimethysuccinyl)betulinic acid; BVM; also known as PA-457 or DSB] potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking ...
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HIV-1 Maturation Inhibitor Bevirimat Stabilizes the Immature Gag Lattice
... Similar but not identical departures from normal maturation occur in CA5 particles. Here, we also observed acentric masses without surface shells that we would assign to NC plus vRNA (as above). In addition, we ...
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Protease mediated maturation of HIV: Inhibitors of protease and the maturation process
... Conclusion. Maturation inhibitors are a novel mech- anistic class of antiretroviral drug that target PR cleavage sites in ...first-in-class maturation inhibitor, which specifically inhibits cleavage ...
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Resistance to Second-Generation HIV-1 Maturation Inhibitors
... HIV-1 maturation by blocking a late step in protease-mediated Gag processing: the cleavage of the capsid-spacer peptide 1 (CA-SP1) intermediate to mature ...level maturation inhibitor ...
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Maturation of the adolescent brain
... The maturation of the adolescent brain is also influenced by heredity, environment, and sex hormones (estrogen, progesterone, and testosterone), which play a crucial role in ...impact maturation of the ...
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Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in Escherichia coli
... lipoprotein maturation and transport, while the C-terminal domain senses cell adhesion to hydrophobic surfaces (11, 12) and defects in disulfide bond formation ...
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Design Principles Of Mammalian Transcriptional Regulation
... fraction is the predominant mechanism by which the LCR enhances b-globin transcription. To bypass potential secondary effects of LCR deletion and to examine the consequences specifically of LCR-promoter contact frequency ...
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Life-history trade-offs influence disease in changing climates: strategies of an amphibian pathogen
... thallus maturation (time to sporulation) and fecundity (number of zoospores produced) were experimentally quantified and examined for the effects of temperature and initial ...
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Effects of inhibiting nitric oxide synthase on cumulus expansion and nuclear maturation of sheep oocytes
... oocyte maturation of some species, there is no report about its effect on the in vitro maturation of sheep ...vitro maturation of ovine ...NOS inhibitor) (0.1, 1 and 10mM) were added to ...
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Metastable Intermediates as Stepping Stones on the Maturation Pathways of Viral Capsids
... a maturation pathway, and Head I* resem- bles an intermediate [EI-like] stage, later than Prohead ...wild-type maturation pathway involves factors other than the structure of the protein ...drives ...
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Influence of sexual maturation status on the relationship between body adiposity indicators and age: a cross sectional study
... sexual maturation, reporting that during the prepu- bertal years, obese children would have higher growth velocity and accelerated bone age compared to lean ...
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Prenatal Exposure to Bisphenol A Disrupts Fetal Liver Maturation in a Sex-Specific Manner
... There is robust evidence that adverse events in early life can permanently alter organ growth and function, leading to a wide range of diseases later in life, including cardiovascular, metabolic, neurological, ...
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Cell volume regulation is initiated in mouse oocytes after ovulation
... It has previously been established that one-cell embryos require glycine uptake and GLYT1 activity to maintain their volume (Steeves et al., 2003). However, when this mechanism is first used during development was not ...
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National Estimates of the Timing of Sexual Maturation and Racial Differences Among US Children
... earlier maturation in non-Hispanic black girls than in non-Hispanic white and Mexican Amer- ican ...of maturation than the non-Hispanic white and Mexican American boys for pubic hair and genital ...
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