Mda-5
Interstitial lung disease in clinically amyopathic dermatomyositis with and without anti-MDA-5 antibody: to lump or split?
... injury not only to the skin and lung, but also to the liver. 2) Furthermore, the CD4 + /CD8 + ratio in the BAL fluid was significantly higher in the positive group than in the nega- tive group. No previous reports have ...
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MDA-5 associated rapidly progressive interstitial lung disease with recurrent Pneumothoraces: a case report
... Capillaroscopy showed pattern of systemic sclerosis. CT chest showed early ILD. Electromyography and MRI showed features of mild myositis. PFT showed muscle weakness with low DLCO. She was given intravenous steroid and ...
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Amyopathic Dermatomyositis (Anti-MDA 5 disease) with pulmonary fibrosis and features of lupus, without evidence of malignancy: A Case Report
... A 44-year-old Hispanic female with a past medical history of Hypothyroidism presented from her endocrinologist with a diffuse, maculopapular rash, including the face, hands, wrists, torso, arms and legs. The rash had ...
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The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3
... of MDA-5 in rotavirus recognition was not examined in that study, our results support the involvement of both MDA-5 and RIG-I in rotavirus recognition in a MAVS/IPS-1- dependent ...and ...
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MDA-5 Is Cleaved in Poliovirus-Infected Cells
... of MDA-5 during poliovirus infection might be a mechanism to evade the innate immune response by attenuat- ing the production of IFN, thereby allowing higher levels of viral ...of MDA-5 is ...
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Proapoptotic signaling induced by RIG I and MDA 5 results in type I interferon–independent apoptosis in human melanoma cells
... antigen 5 (MDA-5) helicases sense viral RNA in infected cells and initiate antiviral responses such as the production of type I ...and MDA-5 also initiate a proapoptotic signaling ...
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Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins
... inhibit mda-5 activation by binding to the helicase domain and preventing it from binding dsRNA, thus inhibiting ...targets mda-5 and not ...of mda-5 or IPS-1 ...
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Original Article Premature ovarian insufficiency induced by tripterygium glycoside: does melatonin offer protection?
... of MDA-5, SOD-1 and AMH in the ovaries was ...downregulated MDA and upregulated SOD, GSH-Px and AMH levels in serum and ovarian homog- enates, and decreased MDA-5 and increased SOD-1 ...
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Yeast Virus-Derived Stimulator of the Innate Immune System Augments the Efficacy of Virus Vector-Based Immunotherapy
... To identify novel stimulators of the innate immune system, we constructed a panel of eight HEK293 cell lines double positive for human Toll-like receptors (TLRs) and an NF-B-inducible reporter gene. Screening of a large ...
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Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis
... and MDA-5, and this is independent of TLR-3, TLR-7, and TLR-9, whereas immune cells such as plasmacytoid dendritic cells rely on TLRs rather than RIG-1 or MDA-5 to produce antiviral cytokines ...
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BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells
... NT_009952.14, -1082 to +118), was used to prepare the reporter constructs. DNA was extracted from MDA- MB-435 cells. BLyS promoter was amplified by PCR using following primers: 5’- GCG GTA CCA AGC CTG GGT ...
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Assessing the interruption of the transmission of human helminths with mass drug administration alone: optimizing the design of cluster randomized trials
... Once MDA stops, which age profiles of worm burdens in the host population lead to elimination in the long term and which to parasite bounce back are not known in ad- ...post MDA cessation to maximize the ...
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EFFECTS OF STORAGE ON AUTO OXIDATION LEVELS OF SELECTED ALCOHOLIC AND NON ALCOHOLIC BEVERAGES IN NSUKKA TOWN, ENUGU STATE OF NIGERIA
... like MDA has been associated with a variety of chronic diseases in both human and model ...of MDA indicates high levels of lipid ...of MDA in beverages, food, plants, human, model system ...
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<p>Knockdown of lncRNA <em>PCAT6</em> Enhances Radiosensitivity in Triple-Negative Breast Cancer Cells by Regulating<em> miR-185-5p</em>/<em>TPD52</em> Axis</p>
... and MDA-MB-231) relative to breast epithe- lial cells (MCF-10A) (Figure ...in MDA-MB -468 and MDA-MB-231 cells transfected with miR-185-5p mimics (Figure 4F), suggesting that successful introduction ...
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Original Article DLC-3 suppresses cellular proliferation, migration, and invasion in triple-negative breast cancer by the Wnt/β-catenin pathway
... HCC-1937, MDA-MB-468 and MDA-MB-231 cells compared with the breast epithelial cell line ...in MDA-MB-231 (Figure ...fected MDA-MB-231 ...untransfected MDA-MB-231 group and the ...
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Centella Asiatica Increased the Body Length Through the Modulation of Antioxidant in Rotenone-Induced Zebrafish Larvae
... high level of triterpen in Centella asiatica can provide antioxidant protection33. Asiaticoside contain in Centella asiatica by UHPLC (ultra high performance liquid chromatography) examination of 2.94 ppm.12 The ...
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Brugia Rapid™ antibody responses in communities of Indonesia in relation to the results of ‘transmission assessment surveys’ (TAS) for the lymphatic filariasis elimination program
... for MDA programs in Brugia ...of MDA in 2004) agree with the TAS result suggesting that transmis- sion is still ongoing and that MDA should be ...stopping MDA based on ...
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Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration
... Synovial fluid (SF) functions as a biological lubricant and biochemical pool of nutrients and regulatory cyto- kines. It reduces friction at cartilage–cartilage interfaces in the boundary mode of lubrication [1]. The ...
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Optimizing Age-Structured and Risk-Based Mass Drug Administration Against Soil-Transmitted Helminthiasis in Ghana Using Cost-Effectiveness Analysis
... known, MDA is crucial to control the neglected tropical disease ...no MDA in children and the prevalence decreases over time but not enough to get close to the WHO’s ...
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Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A–dependent phospho Akt inactivation in estrogen receptor–negative human breast cancer cells
... tamoxifen-sensitive MDA- MB-468 cells (Additional file 1: Figure ...including 5-fluorouracil (5-FU), paclitaxel and docetaxel, and compared them with tamoxifen in MDA- MB-468 cells (Additional ...
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