MDA-MB-435
Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells
... and MDA-MB-435- pFDR1 cells was further supported by minocycline stud- ies, which revealed markedly lower MMP9 expression levels and a reduced fusion rate in the presence of TNF- ...
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The Na+–H+exchanger 1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA MB 435 cells
... As shown in Fig. 7, 24 hours of serum deprivation (D) sig- nificantly increased basal, non-serum-deprived (ND) MDA- MB-435 cell motility, measured as their ability to cross a collagen I layer in a ...
13
MicroRNA 374a activates Wnt/β catenin signaling to promote breast cancer metastasis
... miR-374a promoted distant metastasis. Since the in vitro experi- ments revealed that miR-374a expression was associated with prometastatic traits, we next asked whether miR-374a could promote metastasis in vivo. The ...
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γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells
... Multidrug-resistance-associated protein 5 (MRP5) encoded by the ABCC5 gene is associated with resistance to antifolates and 5FU. MRP5 can efflux mono- and di- glutamate forms of methotrexate (MTX) and transport ...
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Tumor-targeting, Systemically Delivered Antisense HER-2 Chemosensitizes Human Breast Cancer Xenografts Irrespective of HER-2 Levels
... decrease in adverse side effects for the patient. Up- take studies shown in Figure 5 demonstrate that there is increased uptake of the F-Lip-2–ODN com- plex in the tumor as compared to free ODN. More- over, in the animal ...
12
Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells
... A greater degree of HERV-K Env protein downregulation was associated with a correspondingly greater decrease in the expression of Ras in Hs578T, MDA-MB-231, MDA-MB-435.eB1, and MCF-7 ...
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Antitumor Activity of Disintegrin Like Components from the Venom of Montivipera raddei
... Previously it was shown that human breast carcinoma (MDA-MB-435) cells adhered to various extracellular matrix proteins, including fibronectin, vitronectin, type I collagen, and laminin [26]. It was ...
8
Evaluation of 64Cu DOTA and 64Cu CBTE2A Galectin 3 Peptide as a PET Radiotracer for breast Carcinoma
... with MDA-MB-435 ...the MDA-MB-435 cells which increased gradually and equilibrium was reached at 1 h, beyond which no further increase in cell associated ra- dioactivity was ...
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Imaging biochemistry: applications to breast cancer
... Bhujwalla ZM, Aboagye EO, Gillies RJ, Chacko VP, Mendola CE, Backer JM: Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: [r] ...
5
Advances in nanomedicine for cancer starvation therapy
... limit the targeting efficiency of nanomedicines, but also weaken their antitumor ability against the tumor central area [79, 80]. Recent studies reported that small free molecule VDAs could help nanomedicines to overcome ...
22
Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography Imaging
... The MDA-MB-435 cell line was purchased from the ATCC and grown in Leibovitz’s L-15 medium supplemented with 10% (v/v) FBS under a 100% air atmosphere at ...
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Near infrared imaging of epidermal growth factor receptor positive xenografts in mice with domain I/II specific antibody fragments
... Normalized fluorescent signal is expressed in arbitrary units (au) and TBR (tumor-to-background ratio) in A-431 and MDA-MB-435 tumor bearing mice. A minimum of three mice were analyzed [r] ...
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Molecular biology of breast cancer metastasis Genetic regulation of human breast carcinoma metastasis
... and MDA-MB-435 human breast carci- noma cells in soft agar was reduced as compared with control transfectants, despite the observations among all transfection studies reported to date that primary ...
9
Original Article Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer
... (MDA-MB-435, MDA- MB-231, and HCC-1937) and a normal mam- mary epithelial cell line (MCF-10A) were ob- tained from the Cancer Research Institute of Beijing, ...3. ...
8
Soluble L1CAM promotes breast cancer cell adhesion and migration in vitro, but not invasion
... L1 functions in the developing nervous system mostly as a cell surface adhesion/recognition protein by homo- philic binding and heterophilic interaction with ECM and other migration guiding cues [15]. It can become ...
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BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells
... NT_009952.14, -1082 to +118), was used to prepare the reporter constructs. DNA was extracted from MDA- MB-435 cells. BLyS promoter was amplified by PCR using following primers: 5’- GCG GTA CCA AGC ...
7
Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells
... the MDA-MB-435 cells survived the application of 15 μg/ml nelfinavir (Figure ...of MDA-MB-435 cells (Figure ...the MDA-MB-435 cells survived the addition of ...
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Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
... α-induced MDA-MB-231, MDA-MB-435 and BT-474 ...TNF-α-induced MDA-MB-231 and MDA-MB- 435 cells, which indicated that the anti-metastatic effect of ...
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MicroRNA-101 inhibits cell progression and increases paclitaxel sensitivity by suppressing MCL-1 expression in human triple- negative breast cancer
... The following cell lines were obtained from the American Type Culture Collection (Manassas, VA, USA) and were passaged in our laboratory for less than six months after the frozen aliquots were thawed: five breast cancer ...
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Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment
... of MDA-MB-231 cells, after 48 hr treatment of MCF7 cells, and after 72 hr treatment of MDA-MB-435 ...in MDA- MB-231 cells ...In MDA-MB-435 cells, ...
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