mdx mice
The chondrogenic response to exercise in the proximal femur of normal and mdx mice
... in mdx mice is a unique ...in mdx mice failed to provide suffi- cient mechanical pressure to yield significant chondral ...of mdx mice of similar age to the ones used in this ...
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Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis
... Several anti-fibrotics have been tested to decrease fibro- sis associated to dystrophic skeletal muscle [43]. Among them neutralizing antibodies against all three forms of TGF-β importantly reduced hydroxyproline levels ...
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Transgenic overexpression of γ-cytoplasmic actin protects against eccentric contraction-induced force loss in mdx mice
... the mdx mouse is increased susceptibility to injury following eccentric muscle con- tractions [7,8], a standard procedure to determine the efficacy of a drug or therapy in preclinical trials ...the mice. ...
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Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice
... of mdx mice resulted in an approximate 20% loss of diaphragm specific force; treatment with 1 mg/kg of prednisone abrogated most of the loss of diaphragm specific force (p = ...
11
The expression of myogenic regulatory factors and muscle growth factors in the masticatory muscles of dystrophin-deficient (MDX) mice
... on mdx orofacial muscles, which revealed that masseter and temporal muscles were affected by dystrophinopathy, while mdx tongue muscles were partially spared ...in mdx gastrocnemius muscles [25] or ...
12
Expression rate of myogenic regulatory factors and muscle growth factor after botulinum toxin A injection in the right masseter muscle of dystrophin deficient (mdx) mice
... dystrophic mice by a specific intramuscular BTX-A ...dystrophic mice showed the same effect for MyoD1 ...dystrophic mice compared to controls, except the left temporal and the tongue ...
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Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice
... THI-treated mice (Figure ...jured mdx muscles ex ...untreated mdx mice were analyzed following incubation with 10 μM S1P ...uninjured mdx muscle (Figure ...
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Myofiber branching rather than myofiber hyperplasia contributes to muscle hypertrophy in mdx mice
... in mdx mice could result from myofiber ...in mdx mice can initiate the expression of growth- associated protein 43 (GAP43), a marker of axonal branch- ing, in motor neurons ...in mdx ...
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Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice
... of mdx mice 3 weeks following treatment, and this improvement persisted for at least 6 weeks after CDC treatment (Figure 1, B and ...vehicle-treated mdx mice (Figure 1D), with an underlying ...
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Adeno-associated Virus Serotype 8 (AAV8) Delivery of Recombinant A20 to Skeletal Muscle Reduces Pathological Activation of Nuclear Factor (NF)-κB in Muscle of mdx Mice
... achieves a high efficiency of transduction of skeletal muscle and heart (23,24). AAV8 efficiently transduces both fast and slow skeletal muscle fibers with equal efficiency (25). Therefore, to ex- plore the potential of ...
9
d-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity
... peptide-treated mdx mice had a significantly increased num- ber of protein bands, which was greater than the number of protein bands ob- served for low-dose D -8K-wild-type- NBD peptide or either low- or ...
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Superpulsed low level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression
... The experiments were started with 6 weeks old male mdx mice, housed in central animal house of Nove de Julho University with a 12-hours light/dark cycle and food and water ad libitum. Animals were purchased ...
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A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice
... the mdx groups ...in mice treated with ...the mdx groups. Unexpectedly, mdx mice treated with AAV9-GDF11PRO-Fc D122A exhibited a slight increase in IgG-positive area on average, but ...
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Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment
... the mdx model(15, ...and mdx models which do not receive ventilatory ...Cmah-/-;mdx mice do exhibit a much earlier and more pronounced cardiac phenotype compared to ...in mdx ...
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Muscle reorganisation through local injection of stem cells in the diaphragm of mdx mice
... The use of cell therapy in the diaphragm muscle was previously describe by Zhang et al., 2006 [33]. They examined the effects of xenotransplantation of bone marrow-derived stem cells isolated from normal rats into the ...
7
Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice
... of premature stop codons can be mediated by amino- glycosides in cultured cells (10, 11). These antibiotics cause extensive misreading of the RNA code and can thereby allow the insertion of alternative amino acids at the ...
8
SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice
... young mdx mice is mildly affected, we opted to test SERCA2a ther- apy in 12-month-old mdx mice ...age, mdx mice exhibit cardiac histopathology but do not suffer heart failure ...
7
Modifying function and fibrosis of cardiac and skeletal muscle from mdx mice
... The role of the cytokine TGF-β was examined by treating mdx mice with the TGF-β antagonist pirfenidone at 0.4, 0.8 or 1.2 % in drinking water for six months. Pirfenidone improved cardiac contractility ...
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miR-146a deficiency does not aggravate muscular dystrophy in mdx mice
... in mdx mice ...in mice lacking ...− mdx vs. WT or mdx, ...younger mdx mice, when the dystrophic phenotype is ...older mdx mice, known to demonstrate ...
17
Modifying function and fibrosis of cardiac and skeletal muscle from mdx mice
... in mdx mice, such mice were crossed with myostatin null mutant ...deficient mdx mice showed less fibrosis, suggesting improved muscle regeneration (Wagner et ...
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