Mechanical hyperalgesia
The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation
... Prearthritic treatment with etanercept reduces postarthritic macrophage accumulation in the dorsal root ganglion (DRG). (a) Inflammation due to complete Freund's adjuvant (CFA) induced a 10-fold increase in perineuronal ...
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Traumatic osteoarthritis-induced persistent mechanical hyperalgesia in a rat model of anterior cruciate ligament transection plus a medial meniscectomy
... operation. Mechanical hyperalgesia was determined weekly by measuring the paw withdrawal threshold values with a von Frey ...of mechanical hyperalgesia changes between nontreated (dotted line) ...
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Identification of mechano sensitive C fibre sensitization and contribution to nerve injury induced mechanical hyperalgesia
... in mechanical hypersensitivity (Gemes et ...nociceptor mechanical sensitisation through intradermal application of nerve growth factor is accompanied by axonal excitability (Hirth et ...to mechanical ...
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PKCε phosphorylation of the sodium channel NaV1 8 increases channel function and produces mechanical hyperalgesia in mice
... Mechanical hyperalgesia is a common and potentially disabling complication of many inflammatory and neuropathic ...underlies mechanical hyperalgesia, but the PKCe substrates involved ...
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Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease modifying antirheumatoid drugs in the adjuvant induced arthritic rat
... The clinical severity of arthritis was also determined by quanti- tating the change in the paw volume (as an indicator of edema) with a plethysmometer (model 7140; Ugo Basile, Varese, Italy) following the ...
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Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice
... of mechanical hyperalgesia compared with the control group (Figure ...carrageenan-induced mechanical hyperalgesia at various experimental time points compared with its nonencapsulated form at ...
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<p>Electroacupuncture Inhibits Hyperalgesia by Alleviating Inflammatory Factors in a Rat Model of Migraine</p>
... evaluated mechanical hyperalgesia using an electronic von Frey esthesiometer in the awake ...paw mechanical hyperalgesia, which was inhibited by ...inhibiting hyperalgesia and ...
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Ameliorative Potential of Standardized Extract of Condalia buxifolia Reissek in Attenuating the Postoperative Pain: Evidence for the Inhibition of AMPA and Kainate in the Spinal Cord
... spontaneous pain elicited by intrathecal administration of glutamate, AMPA and kainate, and also prevented the mechanical hyperalgesia provoked by AMPA and kainate. In agreement with these reports, it has ...
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Effect of Danggui Sini Decoction on the Behaviour and Dorsal Root Ganglion TRP Channel of Neuropathic Pain in CCI Rats
... thermal hyperalgesia and mechanical ...thermal hyperalgesia and mechanical hyperalgesia in CG rats may be realized by down- regulating the expression of ...
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Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain
... secondary mechanical hyperalgesia, as shown by a reduction in paw pressure withdrawal thresholds, in the MIA/vehicle-treated animals compared to control/vehi- cle treated animals (P < ...secondary ...
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EFFECT OF ZONISAMIDE ON CHRONIC CONSTRICTION INJURY INDUCED NEUROPATHIC PAIN IN MALE SD RATS
... Mononeuropathic rats were assessed for mechanical hyperalgesia sensitivity according to the procedure described by Gonzalez et al., [22]. The operated rat was placed inside an observation cage and allowed ...
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TRPV1 channel inhibition contributes to the antinociceptive effects of Croton macrostachyus extract in mice
... Five days after surgery, a significant increase (p < 0.001) on the baseline frequency response was observed in all animals. In the acute treatment (Fig. 2a), oral adminis- tration of MECM (500 mg/kg, p.o.) ...
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Original Article Involvement of P2X7 receptors and downstream ERK pathways in chronic inflammatory pain
... P2X7R was activated and expression increased in inflammatory pain mice. Change trends ma- tched the course of thermal allodynia and mechanical hyperalgesia. It was found that P2X7 gene expression was ...
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Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
... Results: Intraperitoneal administration of poncirin (30 mg/kg) markedly reduced the pain behavior in both acetic acid-induced visceral pain and formalin-induced tonic pain models used as preliminary screening tools. The ...
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Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain
... In vitro data clearly demonstrated a selective interaction of CR4056 with imidazoline I2 receptors. We therefore tried to better characterize the analgesic effect of the compound by administering different antagonists of ...
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Peripheral calcium permeable AMPA receptors regulate chronic inflammatory pain in mice
... of mechanical hyperalgesia when tested 24 hours after CFA injection and measured using the von Frey hair test (P < ...thermal hyperalgesia (P < ...
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Local analgesic effect of tramadol is mediated by opioid receptors in late postoperative pain after plantar incision in rats
... exhibited mechanical hyperalgesia in their baseline values on POD1 and POD2, before drug injections (Figure ...cal hyperalgesia at all time points of the ...exhibited mechanical ...
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Pain when walking: individual sensory profiles in the foot soles of torture victims - a controlled study using quantitative sensory testing
... deep mechanical hyperalgesia, is not typical for per- ipheral neuropathies but has been reported without signs of nerve injury in, for example, chronic regional pain syn- drome [11; Appendix A in ...
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Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes
... found that ZDF rats exhibited enhanced basal extracellular levels of glutamate in the spinal cord, as compared with age- matched lean control rats. Furthermore, ZDF rats exhibited reduced expression levels of GLT-1 in ...
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Efficacy of isothiocyanate-based compounds on different forms of persistent pain
... Purpose: Current pharmacotherapy for persistent pain related to neuropathy or articular diseases is unsatisfactory, due to the large number of unresponsive patients and side effects. Isothiocyanates (ITCs) are a class of ...
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