Mechanisms and Heterogeneity
Mitochondrial dna-related disorders: Emphasis on mechanisms and heterogeneity
... of heterogeneity in mtDNA-related diseases, it is very hard to quantify their ...the heterogeneity and complexity observed in mitochondrial ...pathogenic mechanisms, with a special emphasis on the ...
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Long-term patterns in dissolved organic carbon, major elements and trace metals in boreal headwater catchments: trends, mechanisms and heterogeneity
... to heterogeneity in the landscape, small scale effects controlling DOC production and mobilization at plot scales are not apparent at catchment ...geochemical mechanisms, as relationships between surface ...
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Exploring mechanisms regulating the heterogeneity of Tumor-Associated Macrophages
... study mechanisms involved in changing the TAM phenotypes during tumor growth, we needed a model where there was a correlation between how the TAM population was composed to an easily defined property such as tumor ...
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Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer
... Intratumor heterogeneity is a common phenomenon and impedes cancer therapy and ...the mechanisms of maintaining two phenotypes and controlling phenotypic transition are largely ...two mechanisms that ...
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Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
... different mechanisms to resist the targeting ...resistance mechanisms include activating complementary bypass pathways and phenotypic ...resistance mechanisms to persist in the drug ...intratumoral ...
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Genetic and molecular mechanisms in multiple myeloma: a route to better understand disease pathogenesis and heterogeneity
... abnormalities, heterogeneity, prognosis Introduction Multiple myeloma (MM) is a hematological malignancy affecting terminally dif- ferentiated B-cells and characterized by bone marrow infiltration by plasma cells ...
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Addressing heterogeneity (and homogeneity) in treatment mechanisms in depression and the potential to develop diagnostic and predictive biomarkers
... treatment mechanisms, a common factor is the patient clinician ...address heterogeneity in developing biomarkers, in which a synergistic combination could bring together data-driven in- ductive and ...
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Mechanisms of cancer evolution and drivers of tumour heterogeneity
... Exome sequencing and deep re-sequencing of somatic variants in 54 triple negative breast cancer tumours, coupled with a clustering process (see Computational tools to dissect clonal architecture, below), enabled ...
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Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance
... 9. Future perspectives To increase the survival rates of cancer patients will be impos- sible without improving the efficacy of cytotoxic and targeted anti-cancer drugs. Since drug resistance is the major cause of ...
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Clinical and pathobiological heterogeneity of asthma—Mechanisms of severe and glucocorticoid resistant asthma
... 4. CLINICAL PHENOTYPES OF ASTHMA To identify the characteristic phenotypes of asthma, factor analysis from questionnaire, clinical, and labora- tory data, including baseline pulmonary function and allergen skin prick ...
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Behavioral and Neural Mechanisms of Social Heterogeneity in Attention Deficit/Hyperactivity Disorder
... Although some of our regions display left-lateralized tendencies, the ICNs that our data most closely resemble relate to networks associated with emotional and autonomic processe[r] ...
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The Politics of Infrastructure: the Heterogeneity of Actor-Network and the Power Mechanisms in Governing Telecommunication Infrastructure in Indonesia.
... employed their skills to challenge the established telecommunication industry and regulatory regime in order to gain access to telecommunication technologies—a phenomenon he termed “geek activisms.” I recognize the ...
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Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice
... These TRCP findings suggest that the two types of tremor are differentially associated with physiological and neural circuit mechanisms. In conclusion, we have demonstrated the presence of TRCP only in a certain ...
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Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia
... Relapse in pediatric T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem and is thought to be associated with clonal selection during treatment. In this study we used an established ...
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The inheritance of heterogeneity
... Summary Because of the imprecision inherent to the process of somatic cell evolution in tumors, we propose that this newly identified mechanism, called fuzzy inheritance, serves as the mechanism of heterogeneity ...
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Intratumoral heterogeneity
... ki-67 heterogeneity profile in prostate ...intratumour heterogeneity of PTEN protein expression and the corresponding molecular abnormalities of the PTEN gene in ...OD. Mechanisms of disease: cancer ...
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Heterogeneity of beta type myosin isozymes in the human heart and regulational mechanisms in their expression Immunohistochemical study using monoclonal antibodies
... of heterogeneity of beta-type myosin isozymes (HC beta) in human hearts, immunohistochemical studies using monoclonal antibodies (MoAbs) raised against human ventricular myosin heavy chains were ...
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Heterogeneity as a coordination device
... seller mechanisms perfectly coordinate the visit strategies of ...considers heterogeneity of both buyers and sellers and shows that for a matching value function strictly su- permodular, the allocation is ...
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Essays in Inequality and Heterogeneity
... To see some of the implications for taxation, consider the following stark but illustrative example. Two entrepreneurs start out with the same wealth level—say $1,000 each—but earn different returns on their wealth, say, ...
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CTCF and cellular heterogeneity
... cellular heterogeneity could be the output of nucleotide muta- tion, abnormal of histone modification, transcription factor binding, and also higher order chromosomal struc- tures [2, 13, 41, 53, 83, ...different ...
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