Mechanisms producing gene copy number changes
Analysis of gene copy number changes in tumor phylogenetics
... the number of single gene duplication and loss events between them, a minimum weight tree, includ- ing Steiner nodes if needed, explains the n observed cell count patterns of d probes with minimum total ...
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Identification of Specific Gene Copy Number Changes in Asbestos-Related Lung Cancer
... DNA copy number between two groups of patients with asbestos- exposed and nonexposed lung ...low copy number gains or losses with no high copy number ...
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Copy number variants, diseases and gene expression
... 2009 Copy number variation (CNV) has recently gained considerable interest as a source of genetic variation likely to play a role in phenotypic diversity and ...in copy number among seemingly ...
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Computational insights into the generation of chromosomal copy number changes
... Furthermore, our method may help provide insights into the mechanism of pathogenic de novo duplications. Many CNV detection algorithms can detect these regions for duplication but cannot infer the detailed structure of ...
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Spectrum of EGFR Gene Copy Number Changes and KRAS Gene Mutation Status in Korean Triple Negative Breast Cancer Patients
... Competing Interests: The authors declare that they have no competing interests. * E-mail: [email protected] Introduction Triple-negative breast cancers (TNBCs) are tumors, nominally classified as a diagnosis of exclusion, ...
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Gene Copy-Number Alterations: A Cost-Benefit Analysis
... of gene copy-number changes in developing ...the gene products amplified/deleted in partic- ular ...a gene encoding the GABA A receptor subunit, has been associated with autism ...
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Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes
... by gene amplification events. Thus copy number variation (CNV) is a major mechanism enabling parasite genomes to adapt to new environmental ...
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Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes.
... by gene amplification events. Thus copy number variation (CNV) is a major mechanism enabling parasite genomes to adapt to new environmental ...
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Detecting copy number changes in genomic DNA - MAPH and MLPA
... We found 4 cases involving non-contiguous duplications and/or triplications, suggesting multiple mutational events. The chance of 2 independent duplications is low, and it is more likely that the initial duplication was ...
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Phylogenetic Reconstruction Analysis on Gene Order and Copy Number Variation
... evolutionary mechanisms on the genomic ...for gene order data that combines double-cut-join (DCJ) sorting with the Simulated Annealing algorithm (SA- ...
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Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples
... and mechanisms are often tissue- specific, and the brain shows high levels of DNA methy- lation despite being primarily nonmitotic in postnatal life ...affect gene regulation through DNA demethylation [42] ...
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Distribution, functional impact, and origin mechanisms of copy number variation in the barley genome
... a gene-based CGH design, while our custom array also included non-coding ...the number of CNVs identified is high considering that bar- ley is a diploid species with a very low outcrossing rate (0% to ...
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Distribution, functional impact, and origin mechanisms of copy number variation in the barley genome
... increased copy num- ber at the boron transporter gene (Bot1) confers boron- toxicity tolerance to the African barley landrace ‘Sahara’ ...transporter gene in maize is associated with increased ...
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Human amylase gene copy number variation as a determinant of metabolic state
... 25 amylase within adipose tissue may shed insight into the links between AMY1 CNV and propensity for weight-gain. To the best of our knowledge, no study has yet examined the relationship between the amylase genes and ...
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Dietary Variation and Evolution of Gene Copy Number among Dog Breeds
... Our copy number analysis and results obtained for PHYH were also ...of copy number variable loci, indicating that no other surveyed loci had a profile similar to that of the PHYH ddPCR results ...
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Diversity in Copy Number and Structure of a Silkworm Morphogenetic Gene as a Result of Domestication
... D OMESTICATION represents a relatively recent evolutionary event, occurring over the past 13,000 years after the Neolithic revolution (D iamond 1997; P urugganan and F uller 2009). This process frequently leads to the ...
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Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours
... mtDNA copy number, DNA meth- ylation and nuclear gene expression at different stages of development highlights the need for cells to establish a balance between these three components to promote ...
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Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus
... influences gene expression [13,14,48]. Despite accurate measurement of DEFA1A3 copy number [18], the relationship between gene copy number and expres- sion at this locus remains ...
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Genome-wide analysis of DNA copy-number changes using cDNA microarrays.pdf
... DNA copy-number ...human gene expression 7–9 , human genomic DNA is a far more complex mixture than the mRNA representation of human ...DNA copy-number variation using cDNA microarrays ...
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Gene Copy-Number Variation in Haploid and Diploid Strains of the Yeast Saccharomyces cerevisiae
... that copy-number variation (CNV) is a substantial and underappreciated source of genetic ...the mechanisms leading to CNVs has been ...confer gene dosage-dependent tolerance to formaldehyde ...
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