mechanistic insights
Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach
... Background: Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal ...
12
New mechanistic insights of integrin β1 in breast cancer bone colonization
... new mechanistic insights of our study underline the potential of β1 integrins as a therapeutic target to limit tumor initiation and expansion in patients with bone ...
13
Stress and functional neurological disorders: mechanistic insights
... At the interface between mind and body, psychiatry and neurology, functional neurological disorder (FND) remains poorly understood. Formerly dominant stress-related aetiological models have been increasingly challenged, ...
21
Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets
... Monosodium urate MSU, basic calcium phosphate BCP and calcium pyrophosphate CPP crystals can act on a number of cell types in the joint to drive pro-inflammatory cytokine production, mat[r] ...
8
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
... Complete trisomy 21 universally causes the development of both amyloid plaques and neurofibrillary tangles NFT, typical characteristics of AD brain pathology, by age 40 and approximately[r] ...
36
Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential
... Rheumatoid arthritis (RA) is a chronic, debilitating dis- ease affecting over 1 million people in the United States, and 1 % of the population worldwide [1]. In the current etiological paradigm, autoimmunity to ...
9
Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products
... Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leuke[r] ...
48
Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications
... Therapeutic Potential of Targeting Macrophage Polarization Since the effects of cigarette smoke are propagated by cell signaling proteins and in light of macrophages polarized toward d[r] ...
7
Mechanistic insights into allosteric structure function relationships at the M1 muscarinic acetylcholine receptor
... considerable insights into the location of orthosteric binding pockets and the molec- ular mechanisms underlying ligand binding and receptor acti- vation (7, ...
12
Structure of a Human Astrovirus Capsid-Antibody Complex and Mechanistic Insights into Virus Neutralization
... To assess whether MAb PL-2 binds monovalently or divalently to the HAstV-2 virion, we aligned our previously reported Fab PL-2 structure 31 onto each scFv in the scFv PL-2/Spike2 complex[r] ...
12
Structural and Mechanistic Insights into the Yeast Disaggregase Hsp104
... Hsp104 is a hexameric, AAA+ disaggregase from yeast, which couples ATP hydrolysis to remodeling diverse substrates ranging from amorphous aggregates to amyloid fibers.. A mechanistic und[r] ...
170
Mechanistic insights of Li+ diffusion within doped LiFePO4 from Muon Spectroscopy
... Darr The Li+ ion di usion characteristics of V and Nb doped LiFePO were examined with respect to undoped LiFePO using muon spectroscopy µSR as a local probe As little di erence in di usi[r] ...
7
The coproporphyrin ferrochelatase of Staphylococcus aureus : mechanistic insights into a regulatory iron binding site.
... Ferrochelatase enzymes from the bacterial phyla Firmicutes and Actinobacteria have previously been shown to insert iron into coproporphyrin, and those from Bacillus subtilis and Staphylo[r] ...
18
Structure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insights
... This is the highest-resolution model of a complete V-ATPase complex, revealing insights into its structure and mechanism. A significant obstacle to understanding the changes that accom- pany catalytic cycling in ...
12
Crystal structure of the sodium proton antiporter NhaA dimer and new mechanistic insights
... On the time scales simulated here, the salt bridge between Asp163 and Lys300 typically persisted during the whole length of the simulation, as also observed for the simulations with Asp1[r] ...
17
Mechanistic insights into the desorption of methanol and dimethyl ether over ZSM 5 catalysts
... Clearly, the clustering effect on the ZSM-5 catalyst gives a far higher number of molecules adsorbed as obtained from the detailed elementary step model compared to the density of active[r] ...
16
Mechanistic insights into the effect of imidazolium ionic liquid on lipid production by Geotrichum fermentans
... A series of imidazolium ILs with robust pretreatment capacity for lignocellulosic biomass, namely [Emim] [DEP], [Emim]Cl, [Amim]Cl, [Bmim]Cl, [Bzmim]Cl, [Emim][OAc] and [Bmim][OAc], we[r] ...
13
Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy
... Regardless of whether tumor cell apoptosis is induced by VSV or by recruited immune cells, the end result is very much the same – tumor debulking and the stimulation of an antitumor [r] ...
11
Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes
... We were able to demonstrate transcriptionally that DNL is markedly increased in ob/ob mice compared with wild type on a chow diet as has been previously reported [23], and this was assoc[r] ...
13
Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
... [159]. Mechanistic studies in human neuroblastoma cells reveal that an effective con- centration of 5 μM hydroxytyrosol can protect against methylmercury (MeHg)-induced neurotoxicity, causing upregulation of ...
17