megakaryoblastic leukemia
Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)
... developing leukemia and testicular cancer is much higher than age-matched controls, while women with DS almost never develop breast cancer ...acute leukemia, both lymphoid (ALL) and myeloid (AML), with ...
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Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome
... of leukemia in childhood but a decreased risk of solid tumors in ...acute megakaryoblastic leukemia ...promote megakaryoblastic leukemia in children with ...initiate ...
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The OTT MAL fusion oncogene activates RBPJ mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model
... Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) associated with a poor ...acute leukemia (OTT-MAL) fusion oncogene that results from the t(1;22)(p13;q13) ...
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Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis
... factor megakaryoblastic leukemia-1 (MKL1) mediates myofibroblast differentiation in response to several profibrotic stimuli, but the role it plays in mediating pulmonary fibrosis has not been fully ...
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De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome
... Acute megakaryoblastic leukemia (AMKL) is a type of acute myeloid leukemia (AML), in which majority of the blasts are megakaryoblastic. De novo AMKL in adulthood is rare, and carries very poor ...
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Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1
... yoblastic leukemia 1 (MKL1), megakaryoblastic leukemia 2 (MKL2) and MEF2 activating motif and SAP domain containing transcriptional regulator ...(Megakaryoblastic leukemia 1) moreover ...
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Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190<em> BCR–ABL</em> transcripts
... Abstract: Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the ...
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Mühlich, Susanne (2017): Regulation der transkriptionellen Koaktivatoren Megakaryoblastic Leukemia 1 und 2 (MKL1 und -2) und ihre Bedeutung in der Tumorigenese. Habilitationsschrift, LMU München: Medizinische Fakultät
... Die Ursache für die nukleäre Lokalisation von MKL1 und -2 in DLC1-defizienten HCC-Zellen lag darin begründet, dass der RhoA/Aktin- Signalweg aktiviert und die Phosphorylie[r] ...
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Baicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrest
... showing that baicalein activated Notch signaling in K562 cells [22]. Notch signaling was critical for early stage of megakaryocyte commitment and dysregulation of Notch signaling by OTT-MAL caused AMKL through bind- ing ...
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Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44)
... Acute megakaryoblastic leukemia; AML: Acute myeloid leukemia; DAPI: 4 ′ ,6- diamino-2-phenylindole; D-FISH: Dual-color-fluorescence in situ hybridization; DS: Down syndrome; FAB: French – American – ...
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Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT
... Leukemia relapse is the leading cause of failure after allo-SCT including in transplants from haploidentical donors [1–5, 24]. Most studies comparing haploidentical donors to matched unrelated or related donors ...
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Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies
... lines, BAG956 has been shown to decrease the levels of phosphorylated AKT in a time-dependent manner while no changes were detected in levels of total AKT. Similarly, levels of cyclin D2 decreased with increasing ...
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A novel BCR-ABL1 fusion gene with genetic heterogeneity indicates a good prognosis in a chronic myeloid leukemia case
... Background: Chronic myelogenous leukemia (CML) is a pluripotent hematopoietic stem cell disorder caused by the fusion of the BCR and ABL1 genes. Quantitative RT-PCR (qRT-PCR) is a routinely performed screening ...
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The Philadelphia chromosome in leukemogenesis
... positive leukemia [8–10]. Leukemia stem cells and BCR- ABL kinase domain mutations may be the keys to solve these problems ...myeloid leukemia (AML) [12, 13], acute lymphoblastic leukemia ...
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Drugging the unfolded protein response in acute leukemias
... The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1 α , PERK, and ATF6 α . Studies described the UPR as a critical network ...
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Review Article Hematopoietic Disorders in Down Syndrome
... DS-ALL: The aspirate and biopsy findings of DS-ALL are identical to those for non-DS associated ALL. More than 90% of the DS-ALL are precursor B lymphoblastic leukemia with the remaining being precursor T ...
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IGF-IR determines the fates of BCR/ABL leukemia
... Methods and results: Here we investigated the role of IGF-IR in chronic myeloid leukemia (CML) using the retroviral BCR/ABL transplantation mouse model. Existing antibodies against IGF-IR are not suitable for flow ...
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Original Article Prediction of gene signatures for diagnosing concurrent of acute myeloid leukemia and chronic lymphoblastic leukemia
... Leukemia is a malignant cancer of the blood- forming organs and is characterized by distort- ed proliferation and development of leukocytes and their precursors [1]. Chronic lymphoblastic leukemia (CLL) and ...
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MYC as therapeutic target in leukemia and lymphoma
... lymphocytic leukemia; T-ALL, T-cell acute lymphoblastic leukemia; ALCL, anaplastic large cell lymphoma; BCLU, B-cell lymphoma unclassifiable; BL, Burkitt lymphoma; GC, germinal center; GCB, germinal center ...
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Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
... are not affected. High-dose chemotherapy and novel tar- geted drugs may be able to eliminate the bulk of the neoplasm and to eradicate most CSC (or LSC) in a given tumor or leukemia. These debulking agents are ...
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