MEK/ERK signaling
DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7
... RAS/MEK/ERK signaling pathway via direct association with ...RAS/MEK/ERK signaling via RASSF7 and provide a framework for understanding how DISC1 dysfunction might lead to ...
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MEK/ERK signaling pathway is required for enterovirus 71 replication in immature dendritic cells
... SOS was discovered in Drosophila melanogaster and plays an important role in normal eye development in Drosophila [39,40]. Human SOS (hSOS) has two ho- mologues, SOS1 and SOS2, which are ubiquitously expressed in ...
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Phosphatidylinositol 3-Kinase/Akt and MEK/ERK Signaling Pathways Facilitate Sapovirus Trafficking and Late Endosomal Acidification for Viral Uncoating in LLC-PK Cells
... the signaling pathways responsible for these viral entry processes remain ...(MEK/ERK) signaling pathways involved in sapovirus entry ...these signaling pathways, indicating that PSaV ...
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Original Article IGF-1R promotes the expression of cyclin D1 protein and accelerates the G1/S transition by activating Ras/Raf/MEK/ERK signaling pathway
... Ras/Raf/MEK/ERK signaling pathway proteins as well as cyclin D1 protein were examined in the IGF-1R-inhibited ...Ras/Raf/MEK/ERK signaling pathway, thus further promoting cell ...
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A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets
... the MEK/ERK pathway is ...Notch/Delta signaling among macromeres descendants (Sweet et ...that ERK signaling is not involved in the early signaling that is required for endoderm ...
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Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells
... MAPKs, signaling via MEK/ERK was found to be essential for the development of costimu- lation-mediated resistance to ...two signaling path- ways in the development of glucocorticoid resistance ...
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Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway
... Abstract: Histone acetylation enzyme inhibitor is a kind of high-efficiency and low toxicity drug for cancer. Therefore, as histone acetylation enzyme inhibitor, it is very important to explore the mechanism of ...
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Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway
... MAPK signaling pathway that was ...of MEK proteins and ERK proteins in ovarian cancer cell lines following inhibition of TRIB3 ...the MEK/ERK signaling pathway in ovarian cancer ...
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Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
... that MEK/ERK were downstream compo- nents of epidermal growth factor receptor (EGFR) signaling pathways which can be activated by several stimulus including EV71 infection in various cell types [6, ...
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MEK ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm
... of MEK activity results in the export of hdm2 mRNA being blocked in this nuclear, salt extractable, ...by MEK, of proteins involved in a nuclear export pathway that is required for the transport of a subset ...
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Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway
... GSK-3β, MEK, ERK, the corresponding phosphorylated proteins (Cell Signaling Technology (CST), MA, USA), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH, ...
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Original Article PAR-2 promotes invasion and migration of esophageal cancer cells by activating MEK/ERK and PI3K/Akt signaling pathway
... downstream signaling path- ways PAR-2 regulates will help us better eluci- date the molecular mechanisms of invasion and metastasis in EC ...the MEK/ERK and PI3K/Akt path- ways were suppressed in ...
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Protein kinase Akt activity in human thyroid tumors
... Raf/ MEK/ERK signaling pathway causes growth arrest, accompanied by corresponding cell cycle regula- tors states changes (pRB dephosphorylation, E2F1 down-regulation and p21 WAF1 up-regulation), ...
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Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
... Shc-Ras-MEK-ERK signaling and cell ...downstream signaling molecules were also inhibited in H1299 cells with MCT-1 ...of MEK and ERK were all steadily suppressed by depleting ...
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<p>KIF15 promotes bladder cancer proliferation via the MEK–ERK signaling pathway</p>
... SDS-PAGE and transferred to polyvinylidene difluoride membranes. The membranes were blocked with 5% nonfat milk for 2 hours and were incubated at 4°C overnight with primary antibodies. The primary antibody used for immu- ...
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Mutation of a diacidic motif in SIV PBj Nef impairs T cell activation and enteropathic disease
... mitogenic signaling and kinase activation most likely due to the presence of the ITAM motif in PBj-Nef, which may result in CD3/CD28 co-sti- mulus ...cell signaling pathway, known to activate cells via the ...
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CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway
... Previously, we noted the upregulation of SREBP1 and some lipogenic genes in CVB3-infected cells, which are accompanied by the lipid accumulation in host cells (16). However, the underlying molecular mechanism by which ...
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Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression
... AKT/MAPK signaling pathways ...AKT/MAPK signaling pathway seemed to support the possibility that dioscin not only suppressed tumor progression and metastasis but also overcome TKI resistance in lung ...
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Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells
... of MEK-ERK signaling, in this study west- ern blot analysis also showed that treatment of H292 cells with U0126 for 48 h induced a dose-dependent increase in Mirk/Dyrk1B protein levels (Figure 2C and ...
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Phosphorylation of Beta 3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
... the MEK inhibitor-treated ...insulin signaling in white adipose tissue but not liver (Supplemental Figs 3F and 3G) These data suggest that modest improvement in adipose tissue insulin sensitivity was not ...
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