MEK1/2/Erk1/2
Lipoteichoic acid induces surfactant protein-A biosynthesis in human alveolar type II epithelial cells through activating the MEK1/2-ERK1/2-NF-κB pathway
... Phosphorylated ERK1/2 and MEK1 were immunodetected using a rabbit polyclonal antibody against phosphorylated residues of ERK1/2 and MEK1 (Cell Signaling, Danvers, MA, ...and ...
8
<p>Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma</p>
... Importantly, MEK1/2-ERK1/2 cascade was inactivated after DHC treatment and ERK activator t-butyl- hydroquinone (tBHQ) treatment rescued DHC-induced cell proliferation ...
13
ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
... Background: Natural Killer (NK) cell effector functions are dependent on phosphorylation of the mitogen‑activated protein kinases (MAPK) pathway to produce an effective immune response for the clearance of target cells ...
10
Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway
... isolated from Allium sativum [16]. The cardiovascular- protective effects of DADS have been extensively studied in recent years [17–19]. Garlic extracts can decrease chol- esterol and plasma lipid levels in rats [20, ...
10
ERK1/2 and MEK1/2 Induced by Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Early during Infection of Target Cells Are Essential for Expression of Viral Genes and for Establishment of Infection
... and 2 (ERK1/2) via the PI3K-PKC -MEK ...by 2 h and 4 h ...of ERK1/2 by KSHV and KSHV envelope glycoproteins gB and ...significant ERK1/2 induction was observed ...
22
The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells
... of ERK1/2 [18]. In this study, we found that LRRC4 binds with ERK1/2 and anchors ERK1/2 in the cytoplasm in HEK293 ...the MEK1/2-ERK1/2 interaction in ...
13
Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells
... The activation of the MAPK pathway is a key event in the early phase of cellular responses to growth fac- tor stimulation. Our recent studies showed that the MAPK pathway in airway smooth muscle is regulated by Raf-1 ...
9
miR 322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage
... of MEK1/2 in mesenchymal tissues also manifests in a strong decrease in ERK1/2 phosphorylation, growth reduction, tracheal cartilage disorganization and neonatal death (Boucherat et ...of ...
16
Effect of nicorandil on postoperative myocardial injury, platelet function and inflammatory response in patients with slow reflow in PCI
... Before PCI as well as 1 d and 3 d after PCI, 1-2 mL of cubital venous blood was collected, whole blood RNA separation kit was used to separate RNA from the cubital venous blood for reverse transcription, then the ...
5
High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells
... of Erk1/2 activation increases expression of p27Kip1 in CRC cells with high basal Erk1/2 ...the MEK1/2 inhibitor U0126 or the compound solvent DMSO at the highest concentration ...
7
Key signalling nodes in mammary gland development and cancer Mitogen activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development
... the ERK1/2 MAPK pathway; however, the nature of the deregulation varies between individual tumours and cancer subtypes ...Dys-regulated ERK1/2 signalling alone is usually not sufficient to ...
14
Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway
... reduced MEK1/2 and ERK1/2 ...of MEK1/2 resulted in reduction in MMP-9 expression and activity that correlated with reduced migration and ...reduced MEK1/2 and ...
15
Cisplatin inhibits MEK1/2
... (ERK1/2), MEK1 (1:2000 dilution), polyclonal antibodies against phospho-p44/42 (pERK1/2), (Thr202/Tyr204), phospho- MEK1/2 (Ser217/221), anti-alpha-tubulin (Cell Signaling, ...
13
Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla
... that MEK1/2 or ERK1/2 in RVLM may confer its pro-life actions via the NOS I/PKG cas- ...to MEK1/2 or ERK1/2 activation in RVLM during experimental brain stem ...
9
An invasive tumor cell subpopulation as a therapeutic target in breast cancer
... inhibit MEK1/2 for several reasons 239, 240 ...of MEK1/2 is highly specific as it does not have multiple downstream targets (ERK1/2 is its sole downstream ...
113
Original Article ERK1/2 phosphorylation in the hippocampus is associated with abnormal anxiety-related and social behaviors in Fmr1 knockout mice
... including ERK1 and ERK2, is one key member of the mitogen- activated protein kinase (MAPK) family of ser- ine/threonine kinase in mammalian, function- ing in regulating a series of biochemical pro- cesses, such as ...
9
Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation
... of Erk1/2 and MEK1/2 phosphory- lation, which were observed in Nck1-knockdown T cells, but not in Nck2-knockdown T ...Although Erk1/2 and p38 are MAPK family members, their ...
13
An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2
... these 2 kinases ...AKT, ERK1/2, and IκBα accompanied by IκBα degrad- ation in the AGS cells (Figure ...c-Raf, MEK1/2, and PI3K significantly (P ...and ERK1/2 ac- tivation ...
19
Allosteric MEK1/2 Inhibitors for the Treatment of Cancer: an Overview
... and 2% respectively) ...cancers[3,4,7]. MEK1/2 mutations in human tumors appear to be rare and there is no report in the literature suggesting prevalence of ERK1/2 activating mutations ...
9
Pseudorabies Virus Triggers Glycoprotein gE-Mediated ERK1/2 Activation and ERK1/2-Dependent Migratory Behavior in T Cells
... gE-mediated ERK1/2 phosphorylation in T lymphocytes, we first investigated whether PRV WT and PRV⌬gE showed obvious dif- ferences in their ability to productively infect primary T lympho- ...
8