Melanocortin-4 receptor
Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults
... Abstract Melanocortin 4 receptor (MC4R) has a major role in energy ...and 4 symptoms by 100-mm visual analog scales (VAS); and satiety by ad libitum buffet ...and 4 h (median D ...
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Defect in MAPK Signaling As a Cause for Monogenic Obesity Caused By Inactivating Mutations in the Melanocortin-4 Receptor Gene
... The melanocortin-4 receptor (MC4R) is a Family A G protein-coupled receptor that plays an essential role in regulating energy homeostasis, including both energy intake and ...
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A Polymorphism in the Melanocortin 4 Receptor Gene (MC4R:c.92C>T) Is Associated with Diabetes Mellitus in Overweight Domestic Shorthaired Cats
... The melanocortin 4 receptor (MC4R) gene, encoding a transmembrane G-protein – coupled receptor, has been implicated as a susceptibility gene in human DM and ...This receptor is mainly ...
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Expression of Melanocortin 4 Receptor mRNA in Male Rat Hypothalamus During Chronic Stress
... glucocorticoids receptor antagonist (RU486) on expression of melanocortin 4 receptor (MC4R) mRNA in arcuate nucleus (ARC) of male rats were ...
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Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice
... Obese melanocortin-4-receptor-deficient (MC4R-/-) male mice are reported to have erectile dysfunction, while homozygous MC4R-/- female mice are apparently ...
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A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants
... the melanocortin-4 receptor (MC4R) gene cause severe early-onset obesity, we still do not have effective approaches to correct the defects of these ...the melanocortin-3 ...
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Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
... the melanocortin 4 receptor (MC4R), making this the most common known monogenic cause of human ...mutant receptor showed a responsiveness to αMSH that was intermediate between the wild-type ...
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The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome
... the melanocortin-4 receptor (MC4R) gene, in the development of MetS [3–5]; however, there are some studies that found no such relationship between variants in the MC4R gene and this syndrome [6, ...
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Hypothalamic Expression of Melanocortin-4 Receptor and Agouti-related Peptide mRNAs During the Estrous Cycle of Rats
... Melanocortin- 4 receptor (MC4R) and agouti- related peptide (AgRP) are involved in energy homeostasis in rats. According to MC4R and AgRP effects on luteinizing hormone (LH) secretion, they may ...
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Melanocortin 4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
... melanocortin-4 receptor (MC4-R) is a key element in the hypothalamic control of food intake. Inactivation of the gene encoding this G protein–coupled receptor causes obesity in mice. In ...
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Constitutive activity of the melanocortin 4 receptor is maintained by its N terminal domain and plays a role in energy homeostasis in humans
... The melanocortin-4 receptor (MC4R), a centrally expressed G protein–coupled receptor (GPCR), is essential for the maintenance of long-term energy balance in ...this receptor leads to a ...
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Gene Amplification and Functional Diversification of Melanocortin 4 Receptor at an Extremely Polymorphic Locus Controlling Sexual Maturation in the Platyfish
... by a-MSH or ACTH to produce cAMP, indicating mutational loss of the capacity to transmit agonist-induced signaling to the cell. This might be due to mutations occurring in the third intracellular loop. This region, which ...
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<p>Tracing the effect of the melanocortin-4 receptor pathway in obesity: study design and methodology of the TEMPO registry</p>
... The TEMPO registry (NCT03479437) is a voluntary, prospective, open-ended registry of individuals with rare genetic disorders of obesity due to mutations in genes within the MC4R pathway [r] ...
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Candidate Gene Analysis for Quantitative Traits Using the Transmission Disequilibrium Test: The Example of the Melanocortin 4-Receptor in Pigs
... Population-wide associations between loci due to linkage disequilibrium can be used to map quantitative trait loci (QTL) with high resolution. However, spurious associations between markers and QTL can also arise as a ...
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Mouse models for the central melanocortin system
... leptin receptor, a single-transmembrane-domain receptor of the cytokine receptor ...leptin receptor [11, 28, ...to melanocortin-4-receptor (MC4R) expressing neurons in ...
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Sweet Regulation of Melanocortin Receptor (MC1R, Mc3r, and MC4R) Transcription Activity
... Human melanocortin 1 receptor; Mc3r: Mouse melanocortin 3 receptor; MC4R: Human melanocortin 4 receptor; Promoter model: A promoter model represents a framework of two or ...
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Relationships between <em>FTO</em> rs9939609, <em>MC4R</em> rs17782313, and <em>PPARγ</em> rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men – a preliminary study
... MC4R, melanocortin 4 receptor gene; PPAR γ , peroxisome prolifera- tor-activated receptor gene; GWAS, Genome-Wide Associa- tion Study; T2DM, type 2 diabetes mellitus; HT, hypertension; TS, ...
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Non adrenergic control of lipolysis and thermogenesis in adipose tissues
... the melanocortin 4 receptor (MC4R) in the central nervous system (CNS) play a key role in regulating SNS activity (Berglund et ...of melanocortin receptor signaling in the brain, which ...
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Article: Association of MC4R codon 42 polymorphism with obese/diabetic ethnic Kashmiri population
... of melanocortin 4 receptor (MC4R) gene in obese/diabetic populations of the Kashmir region and workout association of such variations (if any) with the disease ...
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Biased Signaling in Naturally Occurring Mutations in Human Melanocortin-3 Receptor Gene
... D158Y was almost totally devoid of ligand binding and cAMP signaling (Figs. 3-4 and Tables 1-2). The cognate D126 in the MC4R is important for ligand-receptor interaction [55] and our previous ...
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