Melanoma-associated antigen
Active specific immunotherapy in patients with melanoma A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic anti high molecular weight melanoma associated antigen monoclonal antibodies
... high-molecular-weight-melanoma-associated antigen (HMW-MAA) was administered by subcutaneous route without adjuvants to patients with stage IV malignant melanoma on day 0, 7, and ...
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Original Article High expression and frequently humoral immune response of melanoma-associated antigen D4 in glioma
... After deparaffinized and rehydrated by stan- dard method, the sections were heated in eth- ylene diamine tetraacetic acid (EDTA, pH 8.0) for antigen retrieval and then treated in 3% H 2 O 2 to block endogenous ...
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Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen
... was associated with anti-DEC-205-coated NPs (solid line circles) indicated that the specific internaliza- tion mediated through the DEC-205 receptor was driving higher levels of receptor-mediated ...
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Melanoma associated antigen family protein D4: clinical significance and functional relevance in breast cancer
... There is increasing evidence that recurrent metastatic breast cancer arises in part due to the presence of long-lived, slow-cycling, and drug-resistant stem cells. Adult stem cells, known as side population (SP) cells, ...
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Characterization of a recombinant vaccinia virus expressing human melanoma-associated antigen p97.
... Surface expression of p97 antigen by cells infected with recombinant vaccinia virus v-p97NY Cell type Cell type BSC-40 BSC-40 CHO CHO-p97 2A SK-Mel 28 Infecting virus Radioactivity bound[r] ...
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ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma
... (ODF4), melanoma- associated antigen A3 (MAGEA3), and MAGEAB4 mRNAs in transitional cell carcinoma (TCC), using a small amount of cell reverse transcriptase-polymerase chain reaction (RT-PCR) on ...
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Angelman syndrome: review of clinical and molecular aspects
... MAGEL2, melanoma-associated antigen-like 2; SNURF-SNRPN, small nuclear ribonucleoprotein polypeptide N upstream reading frame; PwS-iC, Prader–willi syndrome imprint ing center; UBe3A, ubiquitin ...
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Sequence and Insertion Sites of Murine Melanoma-Associated Retrovirus
... B16 melanoma that spontaneously originated in C57BL/6 mice pro- duces A- and C-type retroviral particles (25, 26, ...BL6 melanoma cells ...the melanoma- derived IAP differs from other previously ...
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HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status
... cutaneous melanoma have also been studied extensively in the last decade, using CD8 þ T cells, which recognize the tumor-associated antigens of, among others, tyrosinase, MAGE-A1 ...
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Original Article Construction, expression and purification of recombinant HBcAg-MAGE-A3 therapeutic cancer vaccine
... Abstract: Objective: To construct and identify recombinant expression of a therapeutic tumor vaccine with HBcAg as a vector. Methods: PCR primers were designed according to the gene sequences of restriction enzyme sites ...
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Exceptional antineoplastic activity of a dendritic-cell-targeted vaccine loaded with a Listeria peptide proposed against metastatic melanoma
... recovered melanoma from mice vaccinated with DCm-peptides or NV mice, transplanted with B16OVA, were analysed by FACS using the following antibodies: anti- CD4-PE, anti-CD8α-PE, anti-CD49b-PE, anti-F4/80-PE, ...
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Summit on cell therapy for cancer: The importance of the interaction of multiple disciplines to advance clinical therapy
... clinical trials are now using genetically engineered DCs to epitope-load HLA antigens [17]. For many years adoptive cellular therapy using genetically engineered cells has been used to treat Hodgkin’s lymphoma. The same ...
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BTLA mediates inhibition of human tumor specific CD8+ T cells that can be partially reversed by vaccination
... of antigen-specific CD8 + T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 ...
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Current perspectives on Mohs micrographic surgery for melanoma
... neck, neither patient’s age nor preoperative tumor size was predictive of surgical margins. In both studies, histological subtype (i.e., LM vs non-LM) was not routinely documented and therefore could not be incorporated ...
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FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
... closely associated with melanoma. Increased oxidative stress in melanoma cells inhibited PI3K/AKT/mTOR pathway through disruption of mTORC1 formation and phosphorylation of downstream targets p70S6K, ...
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Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings
... of PVtR, the average age of patients was 56 years at the mo- ment of onset, equally distributed between males and fe- males. The majority had metastatic cutaneous melanoma. Paraneoplastic vitelliform retinopathy ...
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The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma
... T-lymphocyte antigen-4 (CTLA-4) and its role as a key negative regulator for T-cells have led to the approval of ipilimumab as a new approach to treat unresectable ...been associated with a higher incidence ...
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Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma
... Identification of a novel isoform of MITF-M, MITF-Mdel The MITF-M cDNA fragment was obtained by RT-PCR of the mRNA from human melanoma cell line 624 mel and cloned into the pCDNA3.1/V5-his topo vector. After ...
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Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting
... in antigen-specific immune responses signifi- cantly greater than those induced in adult males (3, 48, ...was associated with significantly increased antigen-spe- cific immune responses, compared to ...
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CD147 silencing inhibits tumor growth by suppressing glucose transport in melanoma
... of melanoma, there are still not effective treatment [9, ...for melanoma [11, 12], but the survival rate remains ...be associated with oncogenic gene, growth factors, interleukin-1, local hypoxia and ...
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