Melanoma-associated antigen (MAGE)
Active specific immunotherapy in patients with melanoma A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic anti high molecular weight melanoma associated antigen monoclonal antibodies
... high-molecular-weight-melanoma-associated antigen (HMW-MAA) was administered by subcutaneous route without adjuvants to patients with stage IV malignant melanoma on day 0, 7, and ...
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Original Article High expression and frequently humoral immune response of melanoma-associated antigen D4 in glioma
... Many MAGE family members and other tumor- associated antigens, which can elicit humoral immunity, have been identified in cancer patients ...of MAGE-D4 in patients with ...against MAGE-D4 ...
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Melanoma associated antigen family protein D4: clinical significance and functional relevance in breast cancer
... Paclitaxel is a microtubule inhibitory chemotherapeutic drug that is increasingly used for the treatment of solid tumours. In vitro studies have demonstrated that attenuating the spindle assemble checkpoint (SAC) alters ...
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Original Article Construction, expression and purification of recombinant HBcAg-MAGE-A3 therapeutic cancer vaccine
... core antigen (HBcAg) and melanoma-associated antigen 3 (MAGE-A3: 112- ...of MAGE-A3 was synthesized and cloned to ...and MAGE-A3 ...
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HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status
... cutaneous melanoma have also been studied extensively in the last decade, using CD8 þ T cells, which recognize the tumor-associated antigens of, among others, tyrosinase, MAGE-A1 ...
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Original Article Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma
... 1991, MAGE-1 (melanoma associated antigen) gene has been cloned from melanoma cells [14], dozens of MAGE genes have been identified ...the MAGE proteins are termed as CTAs ...
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Characterization of a recombinant vaccinia virus expressing human melanoma-associated antigen p97.
... Surface expression of p97 antigen by cells infected with recombinant vaccinia virus v-p97NY Cell type Cell type BSC-40 BSC-40 CHO CHO-p97 2A SK-Mel 28 Infecting virus Radioactivity bound[r] ...
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ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma
... ODF4, melanoma- associated antigen (MAGE) A3, and MAGEB4 mRNA were detectable in more than 50% of both TCC tissues and urinary exfoliated cells and in less than 20% of tumor-free matched, ...
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CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce anti-tumor immunity against gastric cancer ex vivo and in vivo
... tumor antigen peptide, or protein; fusing tumor cells with DC; and transducing genes encoding tumor antigen, cytokines, or chemokines into DCs ...[9]. Melanoma-associated antigen gene-1 ...
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Angelman syndrome: review of clinical and molecular aspects
... MAGEL2, melanoma-associated antigen-like 2; SNURF-SNRPN, small nuclear ribonucleoprotein polypeptide N upstream reading frame; PwS-iC, Prader–willi syndrome imprint ing center; UBe3A, ubiquitin ...
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Immune cell therapy for hepatocellular carcinoma
... effects associated with gene-modified T cell ...of antigen recognition and proliferation of CAR-T cells, but in studies using xenogen- eic mouse models, monocyte/macrophage also plays a role in the onset of ...
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Original Article MAGE-A3 is highly expressed in a cancer stem cell-like side population of bladder cancer cells
... 185 bp. PCR was carried out under the follow- ing conditions: for ABCG2, denaturation for 30 s at 95°C followed by annealing for 30 s at 63°C, then elongation for 30 s at 70°C, 35 cycles total; CD133 was identical to ...
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Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E
... In situ proximity ligation assay (in situ PLA) A375 cells were grown directly on glass coverslips for 24 h, and then fixed with 3.7% formaldehyde in PBS, and further permeabilized by methanol. After blocking in PBS-5% ...
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Fusion of Hsp70 to Mage a1 enhances the potency of vaccine specific immune responses
... Mice were sacrificed two weeks after the immunization booster was injected. Splenocytes were isolated using EZ-Sep Mouse 1X Lymphocyte Separation Medium (Dakewe, China) according to the manufacturer's in- structions. ...
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Mechanisms that regulate androgen receptor transcriptional activity
... Figure 3-11. MAGE-11 FXXIF Motif-Dependent Interaction with TIF2. (A) top panels, FLAG-b empty vector (lane 1) (—) or FLAG-TIF2.8-(1011–1179) (lanes 2–4) (8 μg) were expressed in COS cells with 0.5 μg of ...
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Urine exosome gene expression of cancer-testis antigens for prediction of bladder carcinoma
... After confirmation of exosome isolation through SEM and western blot analyses, we assessed the expression of seven CTAs along with NMP22 in all samples. SYCP1, OY-TES, NY-ESO-1, and AKAP4 expressions were not detected in ...
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Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma
... an antigen to the T-cell receptor by the major histocompatibility complex class I or II molecules on an antigen presenting ...the antigen presenting cell. Upregulation of cytotoxic T lymphocyte ...
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Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma
... The melanoma antigen (MAGE) family, which includes more than 25 members, is classified into two subfamilies based on the structural differences of the genes and tissue- specific gene ...I MAGE ...
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Vulvar melanoma: management of primary disease and repeated recurrences
... cutaneous melanoma, but a large study of vulvar melanomas showed regression in 25% of ...was associated with improved disease-specific survival and overall ...cutaneous melanoma as a prognostic ...
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Original Article Expression and clinical significance of cancer-testis genes in clear cell renal cell carcinoma
... to MAGE-A3 (mouse monoclonal antibody; Santa Cruz Biotechnology, CA, USA) was incubated at 1:500 overnight then 1:2000 secondary anti- body (horse anti-mouse antibody; Santa Cruz Biotechnology) was incubated for 2 ...
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