Melanoma Cell
In Vitro Effect of Steroids on Melanoma Cell Growth—A Prelude to Melanoma Treatment?
... in melanoma than post-menopausal women and men of any age [11], suggesting the involvement of sex steroids in the protection ...of melanoma growth [12] [13] ...of melanoma cell lines [15] [16] ...
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Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
... malignant melanoma in the last few years, with these drugs now commonly used in ...clinic. Melanoma cells treated using these agents are known to exhibit increased levels of melanin pigment and tyrosinase ...
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miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN.
... PTEN is a well-known antioncogene, and exerts a tumor-suppressive effect during uveal melanoma pathogenesis (Abdel-Rahman et al., 2006; Sun et al., 2015a). Moreover, loss of PTEN expression is associated with ...
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High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma
... leukemia cell differentiation and growth arrest; the cytoplasmic domain of LIFr is capable of STAT3 signal transduction even when LIFr forms a homodimer [28, ...modifying melanoma cell ...in ...
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Activation of Notch1 signaling is required for β catenin–mediated human primary melanoma progression
... in melanoma, we therefore determined whether suppression of Notch signaling would inhibit melanoma ...Treating melanoma cell lines (WM35, WM115, and WM3248 from primary lesions; 1205Lu and ...
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Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells
... that melanoma is initiated and maintained by a small population of malignant cells called cancer-initiating cells (CICs) that exhibit stem-cell-like ...in melanoma tumor cell ...human ...
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Orally administered endoxifen inhibits tumor growth in melanoma-bearing mice
... With the growth in understanding of the importance of cytochrome P450 2D6 (CYP2D6) polymorphism and its relationship with the therapeutic outcome of tamoxi- fen in patients with breast cancer [6], we can now partly ...
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The combination of MLN2238 (ixazomib) with interferon-alpha results in enhanced cell death in melanoma
... to cell sensitization to treatment with proteasome ...wild-type melanoma cell lines used in this ...metastatic melanoma, which demonstrated no clinical anti-tumor activity, since BRAF status ...
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In Vitro Determination of Biological and Anabolic Functions of Weak Androgen Dehydroepiandrosterone (DHEA) Using a Variety of Cell Lines
... mouse melanoma cell growth, whereas DHEA affected only marginally human melanoma cell ...cancer cell growth even at 100 μM ...muscle cell and decreased fat cell dif- ...
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Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated
... and cell proliferation in 36 melanoma cell lines and also with better 5-year overall survival in patients with ...in melanoma cells with lower GCLC expression ...
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Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models
... of melanoma cell ...human melanoma tissues in a cancer stage dependent ...primary melanoma cells and 451Lu metastatic melanoma ...in melanoma cells after exposure to atRA at ...
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SHP2 phosphatase as a novel therapeutic target for melanoma treatment
... in melanoma patient samples ...in melanoma, SHP2 may also be required for melanoma pathogenesis and ...promotes melanoma cell viability, motility, migration and anchorage-independent ...
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Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors
... apoptotic cell death induced by vemurafenib or ...increased cell death in A375 and SKMEL28 cells treated with vemurafenib or thapsigargin (Figures 4E–4F and ...vemurafenib-induced cell death in ...
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The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma
... mouse melanoma invasion via the Src-Tks5 pathway in cells overexpressing constitutively active Src and/or Tks5 ...in melanoma growth has not been ...in melanoma progression is not ...in ...
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Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage
... on melanoma cancer cell growth and the molecular mechanism underlying these effects using different human melanoma cell lines as an in vitro ...of melanoma cell lines (A375, ...
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Interleukin-32 induces migration of human melanoma cells through downregulation of E-cadherin
... Based on the results of our in vitro experiments, we used a lung metastasis mouse model to examine whether IL-32α can affect invasion ability in vivo. Because no mouse homolog of IL-32 has been discovered, G361-vector ...
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AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
... B16F10 melanoma cells (our observation), was selected as a reference antigen for measuring MA-specific T cell response because MAGE antigens are AIRE-dependent antigens expressed by mTECs [17-21] and have ...
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Evaluation of a multi marker immunomagnetic enrichment assay for the quantification of circulating melanoma cells
... A2058 cells were harvested as previously described. Only cells with greater than 90% viability were used. Cells were spiked into DMEM/10% FBS or white blood cells (WBCs) resuspended in 1 ml incubation buffer (0.5% BSA, 2 ...
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Metastatic balloon cell malignant melanoma: a case report and literature review
... of melanoma. Balloon cell nevi have centrally located nuclei with no nu- clear pleomorphism and no mitotic ...balloon cell nevi, but these were later found to be identified in BCMM as well [1, ...
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Original Article ZFX-mediated down-regulation of FBP1 confers to growth in melanoma
... Total proteins were extracted from correspond- ing cells using the RIPA buffer in the presence of Protease Inhibitor Cocktail (Thermo Scientific, Rockford, IL, USA). The protein con- centration of the lysates was ...
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