Melanoma progression
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells
... and melanoma is the most aggressive type, exhibiting locoregional invasiveness and early distant dissemination ...of melanoma invasion and metastasis has fueled intensive ...influence melanoma ...
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Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb
... in melanoma progression, and the molecular mechanism regulating its ...with melanoma pro- gression, resistance to apoptosis and poor prognosis ...including melanoma me- tastasis, angiogenesis, ...
14
Gene network analyses point to the importance of human tissue kallikreins in melanoma progression
... each melanoma sample, we counted the number of induced or repressed samples that comprised a melanoma set discriminated according to pathological or clinical tumor characteristics: tumor subtype (PCM and MM ...
15
Increased HOX C13 expression in metastatic melanoma progression
... This study was approved by the ethics committee of National Cancer Institute “ G. Pascale ” . Our series included nevi, primary melanomas and corresponding metastatic tissues from the same patients and an independent ...
10
The multifaceted role of CD146/MCAM in the promotion of melanoma progression
... culture melanoma cells ...in melanoma cells positively regulated ...CD146-transduced melanoma cells was dem- onstrated by the cellular inhibition of the pro-apoptotic protein BAD, the cellular ...
11
<p>MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2</p>
... of melanoma, we explored the targets of miR-1246 in the TargetScan ...In melanoma tissues, a negative correlation was detected between miR-1246 and FOXA2 ...
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Original Article MiR-135 post-transcriptionally regulates FOXO1 expression and promotes cell proliferation in human malignant melanoma cells
... malignant melanoma progres- sion has not been ...malignant melanoma, and further suggest that miR-135a is an onco-miR- NAs and might represent a potential therapeu- tic target for malignant ...
11
Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis
... the melanoma cell undergo apoptosis (Figure 5 and Figure ...Starving melanoma cells will release VEGF to induce the angiogenesis for nu- ...decrease melanoma progression and inhibit ...
19
RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb
... in melanoma cells To explore the functional role of RASSF8 in melanoma cells, Wm266-4, a melanoma cell line with low RASSF8 expression, was transfected with RASSF8 expression plasmid to overexpress ...
13
CDH22 hypermethylation is an independent prognostic biomarker in breast cancer
... with melanoma progression, and with worse 5-year PFS, and a similar, though not signifi- cant pattern, was observed for 5-year OS [16]; in colorectal cancer CDH22 overexpression was signifi- cantly and ...
8
Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study
... previous study, where RBM3 was demonstrated to be one of five down-regulated genes in an in vitro model of melanoma progression [20]. Moreover, as RBM3 has been demonstrated to be a good prognostic ...
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The modulation of Dicer regulates tumor immunogenicity in melanoma
... desmoplastic melanoma subtypes had low Dicer expression that correlated with more advanced tumors and poor patient ...that melanoma had low Dicer expression that correlated with poor patient ...all ...
11
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
... static melanoma samples from TCGA with the MS1 signature had significantly inferior survival (~20 months for MS1 ...in melanoma, that is, methylation gradually decreases with progression (inversely ...
15
Receptor tyrosine kinases and their activation in melanoma
... in melanoma progression (drivers); others may represent passengers (random, neutral ...in melanoma describe mutations in MET, KIT and FGFR2, the last being inactivating mutations reminiscent of the ...
33
Therapy for metastatic melanoma: the past, present, and future
... metastatic melanoma who expressed at least one pro- tein tyrosine kinase (c-kit, platelet derived growth factor receptors, c-abl, or abl related gene) demonstrating a response in only one patient, interestingly in ...
10
Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival
... vitro. We choose as selective COX-2 inhibitor celecoxib and compared its effect to naproxen, a NSAID less than 5 fold selective for COX-2 [9, 10]. Celecoxib was selected since is known to exhibit the greatest potency ...
9
Dabrafenib for treatment of<em> BRAF</em>-mutant melanoma
... 34. Hauschild A, Grob J, Dimidov LV, et al. An update on BREAK-3, a Phase III, randomized trial: dabrafenib (DAB) versus dacarbazine (DTIC) in patients with BRAF V600E-positive mutation metastatic melanoma (MM). ...
9
Patient-reported utilities in advanced or metastatic melanoma, including analysis of utilities by time to death
... including progression model showed a similar pattern of decline in utility as a patient approaches death, with an additional decrement to utility if a patient had experienced disease progres- ...
9
OSskcm: an online survival analysis webserver for skin cutaneous melanoma based on 1085 transcriptomic profiles
... Background: Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically ...
8
Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma
... To assess IRF-1 as a predictive marker for response to PD-1 blockade, serial whole-tissue sections from 47 melanoma patients treated with anti-PD-1 immunother- apy were then stained for IRF-1 and PD-L1 in three ...
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