(membrane-associated)interleukin-1
Alternate Splicing of Interleukin-1 Receptor Type II (IL1R2) In Vitro Correlates with Clinical Glucocorticoid Responsiveness in Patients with AIED
... the interleukin-1 receptor type 2 (IL1R2) (affymetrix ID 205403, nt 1104–1485 (long membrane bound form of IL1R2 (mIL1R2)), was differentially expressed when autologous perilymph was added to PBMC of ...
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Induction of human interleukin 1 by a product of Staphylococcus aureus associated with toxic shock syndrome
... Certain strains of Staphylococcus aureus associated with toxic shock syndrome elaborate material that induces human blood monocytes to secrete interleukin-1 (IL-1). IL-1 was detected ...
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Interleukin-1 Mediates Neuroinflammatory Changes Associated With Diet-Induced Atherosclerosis
... is associated with severe cere- brovascular inflammation in mice and that this effect is mediated by the proinflammatory cytokine interleukin-1 ...type 1 receptor–deficient mice. Systemic ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... I interleukin-1 (IL-1) receptor (IL-1RI) signaling complex using immunoprecipitation and tandem mass ...to interleukin-1 receptor-associated kinase ...remained associated ...
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Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity
... were found in inflammatory conditions such as Crohn’s disease, inflammatory bowel disease, ulcerative coli- tis, infections, necrosis, malignancy, sepsis, and severe trauma [49–51]. Our data showing higher circulatory ...
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Interleukin-1β inhibitors for the treatment of cryopyrin-associated periodic syndrome
... this group reported data for only two patients with MWS, this was the first clinical proof of concept for IL-1-targeting drugs in CAPS. This first report was soon followed by a ret- rospective review of medical ...
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Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin- associated periodic syndromes
... Figure 1 Pathophysiology of ...pro-caspase 1 to ...iL, interleukin; ASC, apoptosis-associated speck-like protein; CAPS, cryopyrin-associated periodic syndromes; UvB, ultraviolet B; LRR, ...
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Interleukin 1 receptor antagonist A new member of the interleukin 1 family
... cell associated. Do these observations suggest that members of the IL-1 family possess important intracellular functions, as yet undetermined? IL-1 alpha may play an intracellular role in regulating ...
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Interleukin-1 antagonists in the treatment of autoinflammatory syndromes, including cryopyrin-associated periodic syndrome
... All patients receiving canakinumab doses noted numerically lower pain scores than those taking triamcinolone acetonide at 72 hours postdosing, and the difference was statistically significant for the 150 mg dose from ...
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Interleukin 1 receptor antagonist ameliorates experimental anti glomerular basement membrane antibody associated glomerulonephritis
... cells/glomerulus, P = 0.002) with IL-1ra treatment at 4 h, respectively. Similarly, the number of glomerular cells staining for lymphocyte function-associated molecule-1 beta (CD18) declined 39% from 16.7 ...
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Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
... As it is well known that the synaptic localisation of receptors and ion channels, together with their protein- protein interactions, are modulated in response to var- ious stimuli, and that they undergo dynamic changes ...
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Targeting interleukin-1 receptor-associated kinase 1 for human hepatocellular carcinoma
... The pathogenesis of HCC is complex and diverse, in- volving different signal pathways, such as Wnt [33, 34], MAPK [30, 35, 36] and PI3K/AKT [31]. Recent studies also showed that inflammation signal pathways were closely ...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
... as Interleukin-1 and Tumor necrosis factor alpha; as pro-inflammatory cytokines; IL-6, IL-10; as regulatory cytokines; VDR; as a connective tissue metabolism-associated-gene; that are ...
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Assessment of Pro-Inflammatory Cytokines Level in Stored Blood for Transfusion in Port Harcourt, Nigeria
... as interleukin 1 beta (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) released by white blood cells during storage ...
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Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... cytokines interleukin 1 (IL1), tumour ne- crosis factor alpha (TNFalpha), and interleukin 6 (IL6), in particular, have been identified and intra-articular as well as systemic levels of these ...
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The expanding spectrum of rare monogenic autoinflammatory diseases
... Autoinflammatory diseases arise from disorders of the innate immune system [1]. The prototype disease is familial Mediterranean fever (FMF), which belongs to the group of hereditary recurrent fevers. Periods of ...
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Diagnostics and Therapeutic Insights in a Severe Case of Mevalonate Kinase Deficiency
... was associated with nephritis and successfully treated with anakinra (interleukin 1 receptor antagonist) is reported here, and new insights into diagnosis and therapy of this complex disorder are ...
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Granulocyte-Macrophage Colony-Stimulating Factor Amplification of Interleukin-1β and Tumor Necrosis Factor Alpha Production in THP-1 Human Monocytic Cells Stimulated with Lipopolysaccharide of Oral Microorganisms
... chemotherapy. Interleukin-1 b (IL-1 b ) and tumor necrosis factor alpha (TNF- a ) play important roles in inflammatory processes, including exacerbation of periodontal diseases, one of the most ...
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Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock
... antagonist, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, intercellular adhesion molecule-1, high mobility group box- 1, D-Dimer and caspase-3), and organ ...
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Ursodeoxycholic Acid May Inhibit Deoxycholic Acid-Induced Apoptosis by Modulating Mitochondrial Transmembrane Potential and Reactive Oxygen Species Production
... For example, Bcl-2 expression at the mito- chondrial outer membrane inhibits the apoptosis induced by interleukin- 1,(-converting enzyme,.. the mammalian homolog of the C.[r] ...
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