membrane disruption
Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly
... mediate membrane disruption. Generally, the membrane lytic factor of nonenveloped viruses is also shielded from the exter- nal environment, perhaps to avoid nonproductive interactions with membranes ...
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Strategy for Nonenveloped Virus Entry: a Hydrophobic Conformer of the Reovirus Membrane Penetration Protein μ1 Mediates Membrane Disruption
... enigmatic. Membrane penetration by the nonenveloped mammalian reoviruses is believed to deliver a partially uncoated, but still large ( ⬃ 70-nm), particle with active transcriptases for viral mRNA synthesis ...
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Functional Genetic and Biophysical Analyses of Membrane Disruption by Human Adenovirus
... ⌬ membrane binding or pro- tein secondary structure ...attenuates membrane lysis and ...(B) Membrane binding of various VI constructs was determined by monitoring changes in intrinsic tryptophan ...
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Sensitivity Evaluation of Two Human Breast Cancer Cell Lines to Tamoxifen through Apoptosis Induction
... tochondrial membrane permeability potential disruption was assessed in both cell lines by a li- pophilic cationic dye (DePsipher assay, Trevigen, ...mitochondrial membrane disruption to early, ...
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The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes
... microbial membrane disruption by PHMB, we observed cell entry into a range of bacterial species, and treated bacteria displayed cell division arrest and chromosome condensation, suggesting DNA binding as an ...
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Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall
... basement membrane defects were only transiently expressed before they were repaired by the overlying endothelium via a mechanism that required active protein and RNA ...basement membrane disruption ...
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Early membrane damage during coronary reperfusion in dogs Detection by radiolabeled anticardiac myosin (Fab')2
... Because membrane disruption may be an important mechanism of irreversible cell injury, we measured changes in cell membrane integrity early during reperfusion using radiolabeled anticardiac myosin ...
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Influence of α-terpineol on the growth and morphogenesis of Penicillium digitatum
... Membrane permeability parameters, including loss of 260 nm absorbing materials, change in extracellular conductivity, and extracellular pH, were used to reflect the integrity of membrane. These parameters ...
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Effect of Mutations in VP5* Hydrophobic Loops on Rotavirus Cell Entry
... Experiments in cell-free systems have demonstrated that the VP5* cleavage fragment of the rotavirus spike protein, VP4, undergoes a foldback rearrangement that translocates three clustered hydrophobic loops from one end ...
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Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence
... pathogen membrane (reviewed in references 24 and 60). The membrane disruption activity of the AMPs is reminiscent of the mem- brane disruption caused by fluconazole, which is lethal to strains ...
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Targeted Oncolytic Peptide for Treatment of Ovarian Cancers
... For clinical development, a LHRH receptor targeted novel, more potent cytolytic peptide conjugate was designed, synthesized and tested to increase toxicity and specificity to cancer cells without harming red blood cells. ...
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Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
... aSyn-mediated membrane disruption Data from several studies suggest that aSyn self-assembly at the membrane surface can promote a disruption of bilayer in- tegrity via a mechanism involving ...
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The VP4 Peptide of Hepatitis A Virus Ruptures Membranes through Formation of Discrete Pores
... viral membrane- active peptides is expected to depend on the nature of the limiting ...limiting membrane for HAV entry is not clearly known, with support existing in the literature for both entry through ...
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Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate
... in membrane potential and the class III ß-tubulin may represent, in part, the alter- ations by ...inner membrane contains the electron transport-proteins that move metabolites across the membrane, ...
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Internal and Surface-Localized Major Surface Proteases of Leishmania spp. and Their Differential Release from Promastigotes
... containing domains with M  CD only promotes release of surface-localized MSP, stationary-phase promastigotes were treated with 15 mM M  CD for 3 h after surface biotinylation. Control cells were treated identically but ...
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Phenotypic and transcriptional analysis appear that bacterial cell wall assembly stop by conserved inner membrane protein (ElyC) gene disruption stimulates the enterobacterial common antigen (ECA) gene cluster transcription in Escherichia coli
... We therefore observed that the ECA biosynthesis genes was expressed in the WT cells of E. coliat low temperature 22°C, and more expressed in ∆elyC and ∆mrcB mutants associated with the overexpression of uppS gene (data ...
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Mechanical Forces Used for Cell Fractionation Can Create Hybrid Membrane Vesicles
... To progress and widen our understanding of molecular processes, we must break open the outer membrane and explore the inner works of the cell. A gamut of methods has evolved to answer such a need, especially cell ...
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Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta
... basement membrane. (A-C) Mural cells promote vascular basement membrane deposition in ...basement membrane components collagen IV and fibronectin in 3D collagen matrix assays with ECs alone (black) ...
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Exploration of anti Malassezia potential of Nyctanthes arbor tristis L and their application to combat the infection caused by Mala s1 a novel allergen
... Interestingly, Mala s1 has been spotted as the major allergen in the yeast and its capacity to stimulate the immune system is well documented, but its antigenic- ity has not yet been elucidated. Despite the fact that its ...
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Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?
... plasma membrane of kidney tubular cells and the normal ability of this plasma membrane to produce the bioactive lipids of interest ...kidney membrane samples, not only due to its im- portance to cell ...
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