Membrane permeability transition pore
ACTIVITY OF APIGENIN AND QUERCETIN ON RAT HEPATIC MITOCHONDRIAL PERMEABILITY TRANSITION PORE
... as permeability transition has been found to play a vital role in the apoptotic process induced by certain anti-cancer ...mitochondrial membrane permeability transition pore ...
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The effect of permeability transition pore opening on reactive oxygen species production in rat brain mitochondria
... It is well known that the reaction order would be lowered by the excess concentrations of the reagents. Then, plausible explanation of the shift from linear to exponential time dependence of ROS formation, due to the ...
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Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening
... Figure 2: Ubisol-Q10 prevents glutamate induced ROS production and mitochondrial potential loss. (A) ROS production were measured using DHE in Ubisol-Q10 pretreated HT22 cells exposed to glutamate. Ubisol-Q10 normalized ...
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Effect of Methanol Leaf Extract of Blighia Sapida on Mitochondrial Membrane Permeability Transition Pore Opening and Blood Glucose Levels in Normal and Streptozotocin-Induced Diabetic Rats
... mitochondrial permeability transition pore (MPT) opening which are related to the onset, progression and pathological consequences of diabetes ...MPT pore plays an important role in modulation ...
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Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells
... Mitochondrial permeability transition (mPT) is implicated as an important event in the control of cell death or survival and mPT represents a target for the development of cytotoxic ...mitochondrial ...
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a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
... cells with oligomers, in some neurons, induced a sudden drop in mitochondrial NADH, which could be induced by rapid activation of NADH consumption due to uncoupling of mitochondria or by mitochondrial permeability ...
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Protective effects of potassium transport in mitochondria from rat myometrium under activation of mitochondrial permeability transition pore
... induced MPTP may result in uncontrolled increase in matrix volume followed by outer membrane rup ture and induction of apoptosis or necrosis [11]. The change in mitochondrial volume resulting from MPTP opening ...
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Anoxia mediated calcium release through the mitochondrial permeability transition pore silences NMDA receptor currents in turtle neurons
... sulfoxide (DMSO) and 20% pluronic acid] were prepared. Cortical sheets were loaded with Oregon Green for two consecutive 1 h incubations at 3–5°C in each separate vial, followed by a 20 min rinse in normal aCSF. Cortical ...
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The membrane permeability transition in liver mitochondria of the great green goby Zosterisessor ophiocephalus (Pallas)
... dependent MPT pore opening in non-mammalian organisms (Szabò et al., 1995; Vianello et al., 1995), and the phenomenon has never been studied in fish. Many studies in aquatic animals do, however, show mitochondrial ...
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Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes
... permeability in experiments with RLM, injected into 400 mOsm medium containing 0–75 mM TlNO 3 and 125 mM NaNO 3 [29]. The swelling of nonener gized RHM increased steadily when the TlNO 3 concentration was ...
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Vaccinia Virus Infection Disarms the Mitochondrion-Mediated Pathway of the Apoptotic Cascade by Modulating the Permeability Transition Pore
... PT pore. Pore-specific ligands can act directly on components of the pore, resulting in dissipation of the inner-membrane potential and the release of cytochrome c (32, 68, ...the ...
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Regulation of mitochondrial permeability transition pore by PINK1
... trans- membrane potential or the electron transport system, we found that only the mitochondrial transmembrane potential is reduced in PINK1 −/− cells (Figure 2), while enzymatic activities of the complexes ...
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Original Article Effects of hydromorphone postconditioning on ischemia-reperfusion injury in isolated rat hearts and mitochondial permeability transition pore
... chondrial permeability, uncoupling of oxidative phosphorylation, dissipation of the mitochon- drial membrane potential, and cytochrome C (Cyt C) release into the cell ...
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Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
... mitochondrial permeability tran- sition pore (mPTP) ...mitochondrial membrane potential, complex I deficiency and changes in free radical levels, and is thought to be a pathologic con- dition ...
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<p>Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening</p>
... The change of ΔΨ m was detected by using Mitochondrial Membrane Potential Assay Kit with JC-1 (Beyotime Institute of Biotechnology, Shanghai, China) according to the manufacturer ’ s protocol. To be speci fi c, ...
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Mitochondria in energy limited states: mechanisms that blunt the signaling of cell death
... mitochondrial membrane potential – are precisely those that trigger, at least in mammals, the mitochondrion to initiate opening of the permeability transition pore, to assemble additional ...
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Water Reuse: Extenuating Membrane Fouling in Membrane Processes
... on membrane surface [71, ...irreversible pore adsorption and plugging, while FA and the hydrophilic NOM produced a smaller and mainly reversible flux ...
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Correlations between Air Permeability Coefficients and Pore Structure Indicators of Cementitious Materials
... They reported a better correlation of the total pore volume and mean pore diameter of 53... the continuous pores with the air permeability coefficient.[r] ...
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The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin
... 16. Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, ...
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Recombinant Dengue virus protein NS2B alters membrane permeability in different membrane models
... possesses pore-forming activity that modifies membrane permeability with lytic effects on the target membrane, as reported for other ...
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