Merkel cell
Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus Associated Merkel Cell Carcinoma
... the cell, which has important implications for treatment and the evo- lution rate of the ...of Merkel cell polyomavirus to hijack specific cellular processes and produce a tumorigenic pheno- type ...
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Unexpected maspin immunoreactivity in Merkel cell carcinoma
... Merkel cell carcinoma (MCC) is a cutaneous neuroendo- crine tumor firstly described by Toker Cyril in 1972 as trabecular carcinoma of sweat glands ...
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Recent updates in the management of Merkel Cell Carcinoma
... immunosuppression and ultraviolet (UV) light exposure, studies have been conducted focussing on the carcinogenesis of MCC, in particular the role of Merkel cell polyomavirus (MCPyV) and its surrogate marker ...
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Ileocaecal recurrence of Merkel cell carcinoma of the skin: a case report
... Merkel cell carcinoma (MCC) is an uncommon and highly aggressive skin ...from Merkel cells at the dermo-epidermal junction, which are of neu- roendocrine ...basal cell carcinoma and squamous ...
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Identification of epidermal progenitors for the Merkel cell lineage
... Recently, Merkel cell mechanoreceptors were identified as a fourth lineage derived from the proliferative layer of murine skin epithelium; however, the location of the stem or progenitor population for ...
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Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management
... Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population. The incidence of MCC appears to have tripled during the past 20 years; an ...
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Is this the end of cytotoxic chemotherapy in Merkel cell carcinoma?
... of Merkel cell carcinoma (MCC), its benefit remains ...anti-programmed cell death ligand 1 (PD-L1) antibody avelumab for patients with advanced MCC and the limited and controversial data on ...
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Immunotherapy in Merkel cell carcinoma: role of Avelumab
... called Merkel cells, to honor Friedrich Merkel who had first described them in ...the Merkel cells from epider- mal versus neural crest cells has been an area of controversy for a long time, recent ...
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Latest update on the clinical features and management of Merkel Cell Carcinoma
... lymph nodes) have improved survival (substaged as A) compared with those who are evaluated only clinically (substaged as B). Stage II has an additional substage (IIC) for tumours with extracutaneous invasion (T4) and ...
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Immunotherapy for Merkel cell carcinoma: a turning point in patient care
... Merkel cell carcinoma (MCC) is a neuroendocrine-like tumor of the skin. First described in 1972, it is a rare diag- nosis, with an annual incidence of approximately 0.6 out of 100,000 persons in the United ...
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Original Article Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker
... tumors, Merkel cell carcinoma, and mesonephric tumors [18, ...as Merkel cell carcinoma (93.5%) and small cell carcinoma ...small cell carcinomas were mostly positive for TdT ...
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Merkel Cell Carcinoma: A Rare Cause of Hypervascular Nasal Tumor
... renal cell carci- noma and other neuroendocrine carcinomas is based on biopsy results and specific immunostain- ...If Merkel cell tumor is under discussion, preth- erapeutic tumor staging should ...
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Circulating Tumor Cell Cultures as a Predictive Marker during Salvage Therapy of Refractory Merkel Cell Carcinoma with Chemotherapy and Electron Beam Radiation
... The Merkel Cell virus (MCV) encodes two major families of genes: (1) the early-tumor associated large T antigen (LT) and small T antigen (ST), and (2) the late genes (viral proteins [VP]) ...tumor ...
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Merkel cell carcinoma occurring in a black woman: a case report
... MCCs often occur on sun-exposed regions of the skin [8, 9]. The etiology is largely uncertain, though there is some evidence that ultraviolet radiation and immune system depression are important risk factors. More re- ...
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Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC
... all cell lines but mostly in ...the Merkel cell pol- yomavirus has an important function in the pathogenesis of the development of MCC ...the cell line MKL-2 also several mRNA and rRNA ...
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Merkel cell carcinoma of the upper extremity: Case report and an update
... The overall 5-year survival rate for patients with Merkel cell carcinoma is 50% to 68% [38]. Considering the high incidence of local recurrence (27%–60%) regional node involvement (45%–91%) or distant ...
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Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts
... to Merkel cell carcinoma ...host cell type in humans and the concurrent establish- ment of a successful in vitro MCPyV infection model provide important clues for what may constitute a successful in ...
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Ganglioside GT1b Is a Putative Host Cell Receptor for the Merkel Cell Polyomavirus
... The Merkel cell polyomavirus (MCPyV) was identified recently in human Merkel cell carcinomas, an aggressive neuroendocrine skin ...host cell receptor for ...host cell receptor ...
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<p>Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report</p>
... in Merkel cell carcinoma: lessons to learn from 16 cases with correlation of sonography, CT, MRI and ...from Merkel cell ...al. Merkel cell ...
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Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens
... Merkel cell carcinoma (MCC) is the most aggressive skin ...human Merkel cell polyomavirus (MCV) is clonally integrated in ⬃ 80% of MCC ...MCC cell lines using three different short ...
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