merozoite surface protein 1
Changing pattern of the genetic diversities of Plasmodium falciparum merozoite surface protein 1 and merozoite surface protein 2 in Myanmar isolates
... falciparum merozoite surface protein-1 (PfMSP-1) and -2 (PfMSP-2) are major blood-stage vaccine candidate antigens, which play important roles in erythrocyte inva- sion [6, 7], and are ...
13
Diversity and population structure of Plasmodium falciparum in Thailand based on the spatial and temporal haplotype patterns of the C terminal 19 kDa domain of merozoite surface protein 1
... ing found, compared to four and five in Kanchanaburi and Ranong, respectively. Variation in the levels of genetic diversity in geographically isolated populations may be due to variation in the multiplicity of infection, ...
11
Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein 1 (MSP142) administered intramuscularly with adjuvant system AS01
... recombinant protein Plasmodium falciparum vaccine antigens which, when mixed with po- tent adjuvants such as AS01, an Adjuvant System con- taining 3-O-desacyl-4’-monophosphoryl lipid A (MPL) and Quillaja saponaria ...
13
Genetic diversity of Plasmodium vivax revealed by the merozoite surface protein-1 icb5-6 fragment
... Results: The 95 P. vivax isolates collected from Zhejiang province were either indigenous cases or imported cases from different regions around the world. A total of 95 sequences ranging from 390 to 460 bp were obtained. ...
9
Plasmodium falciparum merozoite surface protein 1: Antigenicity, immunogenicity and structure.
... fusion protein and tested as to whether or not they can act synergistically to block parasite ...fusion protein o f Pfs25 and Pfs28 can induce potent transmission-blocking antibodies in mice (Gozar et al, ...
210
Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium falciparum Merozoite Surface Protein-1 in Aotus Monkeys
... surface protein-i (MSP1) of Plasmodium falciparum has been implicated as a target of protective immunity.. Materials and Methods: Two recombinant proteins.[r] ...
8
Antibody responses to the merozoite surface protein 1 complex in cerebral malaria patients in India
... The merozoite surface protein (MSP)-1, a large multipro- tein complex exposed on the surface of merozoites, is one of the well characterized antigens of ...MSP- 1 30 , ...
13
Temporal stability of naturally acquired immunity to Merozoite Surface Protein 1 in Kenyan Adults
... over the time intervals assessed is consistent with this observation. Similarly, in a repeat cross-sectional study of adults and children in western Kenya, IFN-γ T cell responses to LSA and TRAP peptides in adults were ...
10
IMMUNOGENICITY OF THE MEROZOITE SURFACE PROTEIN-1 (MSP-1) OF HUMAN PLASMODIUM SP.
... Besides AS02A, MSP-1 42 was tested with a few other different adjuvants. The adjuvant Alhydrogel was formulated to Plasmodium falciparum MSP-1 42 , with both 3D7 and FVO alleles, and evaluated in 60 ...
7
Merozoite surface protein 1 genetic diversity in Plasmodium malariae and Plasmodium brasilianum from Brazil
... Interestingly, the fragment 2 sequence obtained from the mosquito Plasmodium sample showed a rather different size, presenting a region with a large deletion about a third of the amplifi[r] ...
11
Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum field isolates from Myanmar
... population [36]. Multiple clonal infections with different genotypes of P. falciparum were identified among Myan- mar P. falciparum isolates in a high proportion (79.4% for MSP-1 and 87.3% for MSP-2). And a high ...
8
Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum isolates from Brazzaville, Republic of Congo
... Allelic specific P. falciparum msp-1 and msp-2 geno- typing has shown that malaria parasite population in Brazzaville is highly diverse. However, the number of alleles may have been underestimated due to the limit ...
7
A Novel Malaria Pf/Pv Ab Rapid Diagnostic Test Using a Differential Diagnostic Marker Identified by Network Biology
... marker, merozoite surface protein 1 (MSP1) was discovered by generation of a Plasmodium-specific network and the hierarchical organization of modularity in the ...
12
Multiplicity and molecular epidemiology of Plasmodium vivax and Plasmodium falciparum infections in East Africa
... Background: Parasite genetic diversity and multiplicity of infection (MOI) affect clinical outcomes, response to drug treatment and naturally‑acquired or vaccine‑induced immunity. Traditional methods often underestimate ...
14
Role of Tumour Necrosis Factor (TNF) and Glycosylphosphatidylinositol (GPI) as Important Mediators in the Pathogenesis of Malaria Infection
... of merozoite surface protein-1 (MSP-1 19 ) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic ...
5
Plasmodium berghei circumsporozoite protein encapsulated in oligomannose coated liposomes confers protection against sporozoite infection in mice
... proteins, merozoite surface protein 1 (PfMSP1) and apical membrane anti- gen 1, are the most extensively studied candidates for the development of erythrocytic-stage vaccines ...
10
Genetic diversity of Plasmodium vivax isolates from Azerbaijan
... Merozoite surface protein 1 (MSP-1) marker analyses A portion of the MSP-1 gene (the region encompassing the interspecies conserved blocks ICB5 and ICB6) was amplified using a ...
10
Effect of malaria transmission reduction by insecticide treated bed nets (ITNs) on the genetic diversity of Plasmodium falciparum merozoite surface protein (MSP 1) and circumsporozoite (CSP) in western Kenya
... Several factors have been suggested to play a role in the generation and maintenance of parasite diversity including transmission intensity, immune-mediated pressure, para- site positive rates, rates of multiple-genotype ...
10
Merozoite surface protein-7. A novel protein on the surface of Plasmodium falciparum merozoites
... the merozoite surface, passing through pellicular membranes, to release their contents by exocytosis into the parasitophorous ...erythrocyte surface antigen (RESA) which either crosses the PVM to ...
315
PCR/RFLP Based Analysis of Genetically Distinct Plasmodium vivax Population of Pvmsp 3α and Pvmsp 3β genes in Pakistan
... merozoite’s surface protein-3 were detected by PCR analysis, using standard protocol of Yang et ...using 1 μl of the primary PCR product as the ...
7