Mesangial Cells
Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development
... supporting cells including interstitial fibroblasts, vascular smooth muscle cells (VSMCs) and mesangial cells (Humphreys et ...2011). Mesangial cells are a specialized type of ...
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induced fibronectin production in rat mesangial cells
... Rat mesangial cells were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM) containing ...experiments, cells were passaged 1:5 by trypsinization and allowed to grow overnight before being made ...
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Activation of mesangial cells by the phosphatase inhibitor vanadate Potential implications for diabetic nephropathy
... The metalion vanadate has insulin-like effects and has been advocated for use in humans as a therapeutic modality for diabetes mellitus. However, since vanadate is a tyrosine phosphatase inhibitor, it may result in ...
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Lovastatin inhibits proliferation of rat mesangial cells
... reduced mesangial cellularity and glomerular injury in experimental renal ...glomerular mesangial cells. Growth- arrested mesangial cells were exposed to medium containing 10% fetal ...
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Production of platelet derived growth factorlike protein by rat mesangial cells in culture
... Rat mesangial cells (MC) release a factor that competes in a dose-dependent manner with 125I-labeled platelet-derived growth factor (PDGF) for binding to human foreskin fibroblasts ...in mesangial ...
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Original Article Mitofusin 2 expression in IgA1 induced rat glomerular mesangial cells and IgA nephrology animal model
... glomerular mesangial cells, while overexpressed Mfn2 could alleviate glomerular mesangial cell (GMC) proliferation and increase apoptosis, and that Mfn2 may exert its activi- ties through the ...
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BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R
... human mesangial cells in our ...in mesangial cells was not signifi- ...during mesangial cell growth made it difficult to verify any ...
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Mesangial cells are key contributors to the fibrotic damage seen in the lupus nephritis glomerulus
... One of the main drivers of fibrosis is TGF-β1 therefore we looked at levels of TGF-β1 in each of our models to determine whether this could be driving the fibrotic changes we are seeing. At 4 h post-cytokine treatment a ...
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Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
... endothelial cells was performed giving similar ...thelial cells, as expected, and very low expression in the mesangial ...endothelial cells, but also a con- siderable expression level of about ...
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Effects of chemokines on proliferation and apoptosis of human mesangial cells
... In the kidney expression of chemokines and chemokine receptors are important for the initiation and regulation of inflammatory glomerular diseases [8]. Expression of the chemokines monocyte chemoattractant protein-1 ...
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Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis Alpha smooth muscle actin is a marker of mesangial cell proliferation
... whether mesangial of mesangial proliferative nephritis induced with antibody to the Thy-1 antigen present on mesangial ...a mesangial pattern, correlating with the onset of proliferation, and ...
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Mesangial cells of lupus prone mice are sensitive to chemokine production
... intrinsic cells in the affected glomeruli were observed in the NZB/W mice that received LPS administration [3], the actual mechanisms underlying the accelerated form of the LN model remain largely ...that ...
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Urokinase dependent adhesion loss and shape change after cyclic adenosine monophosphate elevation in cultured rat mesangial cells
... Mesangial cells in culture change shape and become less adhesive in response to cAMP elevation (e.g., treatment with isoproterenol plus isobutylmethylxanthine (IM). Inhibitors of serine proteases inhibit ...
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Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK
... Notwithstanding contradictory observations, studies have identified an association between Hcy and inflammation. For instance, in subject aged ≥ 65 years, IL-6 and IL-1ra cytokines were independent predictors of ...
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Serial analysis of genes expressed in normal human glomerular mesangial cells
... Mesangial cells contain many of the same contractile proteins as smooth muscle cells but some isoforms of these contractile proteins are specific for SMC or MC (review ed in (Stockand and Sansom, ...
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Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells Differential effects mediated by histamine H1 and H2 receptors
... epithelial cells or on cyclic guanosine monophosphate accumulation in epithelial or mesangial ...since mesangial cell contraction is thought to be responsible for ...
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Case report: lipid inclusion in glomerular endothelial and mesangial cells in a patient after contrast medium injection
... and mesangial cells by transmission electron ...and mesangial cells we found CM triggers lipid aggregation along with the increased CD36 and decreased ABCA1 ...
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Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells
... glomerular mesangial cells, re- peated cycles of stretching and relaxation lead to matrix ac- cumulation by stimulating production of extracellular ma- trix and decreasing activity of degradative ...
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Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta stimulated rat mesangial cells
... tumor cells and invasive microorganisms, but it may also damage healthy ...renal mesangial cells not only alters glomerular filtration, but it may also cause tissue injury and thus contribute to the ...
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Evidence for immunoglobulin Fc receptor mediated prostaglandin2 and platelet activating factor formation by cultured rat mesangial cells
... rat mesangial cells free of ...IgG. Mesangial cells preferentially took up 195Au particles covered with BSA-anti-BSA-IgG over those covered with BSA or the F(ab')2 ...all mesangial ...
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