Mesenchymal Stem/Progenitor Cells
Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? A Perspective from Space Flight and Model Systems
... The infiltration of tissues by lipids and fat deposits could not only affect tissue function, but also the ability to repair if indeed the move towards such fatty infiltrates is due to loss of regulatory control of the ...
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Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation
... To evaluate the interactions between ADHLSCs and activated HSCs, indirect co-culture in Transwells was used. HSCs were seeded in the lower chamber of a six-well plate at a density of 1.0 × 10 5 cells/cm 2 , and ...
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Endothelial progenitor cells improve the therapeutic effect of mesenchymal stem cell sheets on irradiated bone defect repair in a rat model
... mononuclear cells were ...streptomycin. Cells of the third passage were tested for osteogenic, adipogenic and chondrogenic differentiation and cell surface ...non-adherent cells were transferred to ...
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Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair
... stromal cells to tissue culture plastic as a mechanism to rapidly isolate progenitor cells from digested IFP tissue, and to then combine this cell source with a transforming growth factor- b 3 (TGF- ...
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Transdifferentiation of human adipose-derived mesenchymal stem cells into oligodendrocyte progenitor cells
... RT-PCR results: After oligodendrocyte differentiation, total RNA extracted from differentiated cells in order to RT-PCR assay. To this end, GAPDH was used as a control marker. Our results revealed that the ...
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Perspectives on endogenous and exogenous tissue engineering following injury to tissues of the knee
... above, mesenchymal stem/progenitor cells (MSC/P cells) have been isolated repeatedly from a num- ber of tissues/sources that would permit autologous ...addition, cells with such ...
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Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis
... target cells, where the exogenous exosomal molecules can regulate target gene or protein expression and recipient cell function [6, ...evoke stem cells-like pro-regenerative effects in injured ...
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Mesenchymal stem cells in arthritic diseases
... Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth in vitro while ...
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Overview of stem cells and their research in burn patients
... these cells have also demonstrated distinct ability to home to a variety of issues (muscles, heart, kidneys, skin, bone, liver, brain), where presumably, they variably contribute to tissue repair and regeneration ...
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Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells
... oval cells as liver progenitor cells (LPCs) or transit- amplifying cells become abundant and highly express cytokeratin 19 and alpha fetoprotein ...intrahepatic stem cells and ...
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Functional similarities of microRNAs across different types of tissue stem cells in aging
... tissue stem cells (TSCs) contribute to loss of tissue homeostasis, including re- ductions in lymphopoiesis and the long-term repopu- lating abilities of hematopoietic stem/progenitor ...
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Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis
... Mesenchymal stem cells (MSCs) can be recruited to the tumor microenvironment and are known as tumor- associated ...cancer stem cells ...stromal progenitor cells (OCSPCs) ...
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Expansion of Cord Blood Hematopoietic Stem Cells on the Amniotic Membrane Derived Mesenchymal Stem Cells
... Clinical trials have basically shown that UCB transplantation causes less graft versus host disease (GVHD) and graft failure (8). Recipients seem to be less sensitive to HLA mismatching when UCB is used as a source of ...
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Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review
... 4444 cells/cm 2 either into static culture flasks containing 10 % FBS DMEM or into computer-controlled stirred suspen- sion bioreactors (DASGIP) containing 500 ml of PPRF- msc6 medium with 2 g/l of Cytodex 3 ...
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Current perspectives in stem cell research for knee cartilage repair
... of stem cells that can be relatively easily acquired, expanded, and selectively committed towards a cartilaginous tissue may provide effective treatments for cartilage lesions in ...patients. ...
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Review Paper: Embryonic Stem Cell and Osteogenic Differentiation
... lineage cells with bone forming capacity are derived from the somatic mesoderm or the ectomesenchymal cells of the neural ...mesodermal progenitor cells or mesenchymal progenitor ...
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Culture and Growth Characterization of Human Mesenchymal Stem Cells from Dental Pulp
... of mesenchymal stem cells (MSCs, a term first coined by Arnold Caplan in 1991, can be traced to experiments demonstrating that transplantation of bone marrow (BM) to heterotopic anatomical sites ...
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Potential role of stem cells in management of COPD
... by stem cells from endogenous and exogenous sources is a promising therapeutic ...resident stem and progenitor cell niches within the lung, the contribution of mesenchymal stem ...
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Mesenchymal chondroprogenitor cell origin and therapeutic potential
... Mesenchymal progenitor cells, a multipotent adult stem cell population, have the ability to diff erentiate into cells of connective tissue lineages, including fat, cartilage, bone and ...
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Vascular stem cells in diabetic complications: evidence for a role in the pathogenesis and the therapeutic promise
... other progenitor cell types, MPCs share properties of both stem cells and mature ...population. Mesenchymal cells in culture typically exude a spindle-like morphology [75], however, ...
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