Mesenchymal Stromal Cell
Mesenchymal stromal cell therapy in COPD: from bench to bedside
... in mesenchymal stromal cell (MSC) therapy have made this approach a strong candidate for clinical use in the treatment of several pulmonary ...
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Bone marrow-derived mesenchymal stromal cell: what next?
... marrow mesenchymal stromal cell (MSC) is a potential alternative in regenerative medicine and has great potential in many pathologic conditions including kidney ...Stem cell feasibility is ...
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Emergence of clonal chromosomal alterations during the mesenchymal stromal cell cultivation
... Use of human mesenchymal stromal cells (MSCs) is a promising strategy for cell therapy in injured tissues re- covery. However, MSCs acquire genetic changes when cultivated in vitro that make them ...
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Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
... Crohn’s disease is a chronic inflammatory disorder of gastrointestinal tract [164, 165]. In the early 1990s, Crohn’s disease patients were reported to experience re- lief from their inflammatory bowel disease following ...
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<p>Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation</p>
... MSCs were obtained from male SPF grade SD rats weighing approximately 80 g using previously described methods. 30 Brie fl y, after sacri fi ce, the bilateral femurs and tibias were separated and disconnected at the ends. ...
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A nanocomposite hydrogel delivery system for mesenchymal stromal cell secretome
... during the tissue repair stages of cell replication and matrix synthesis by secreting extracellular matrix com- ponents thereby maintaining complex interactive micro- environment. Human MSCs and fibroblasts used ...
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The application of resveratrol to mesenchymal stromal cell-based regenerative medicine
... Currently, the transplantation of mesenchymal stromal cells (MSCs) has emerged as an effective strategy to protect against tissue and organ injury. MSC transplantation also serves as a promising therapy for ...
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A magic kick for regeneration: role of mesenchymal stromal cell secretome in spermatogonial stem cell niche recovery
... Sertoli cell functions and contribute to the early stages of spermatogonial lineage expansions by supporting spermatogonia pools through secretions of GDNF, FGF2, and other paracrine factors that are im- portant ...
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Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
... Recent evidence confirmed that early-passage (i.e., passages 2–4) and freshly harvested MSCs have better in vitro T-cell suppression capacity and are associated with more clinical benefits than late-passage and ...
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The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open label pre test: post test study with blinded outcome assessments
... MSC: Mesenchymal Stem Cell / Multipotent mesenchymal stromal cell; MSCIMS: The mesenchymal stem cells in multiple sclerosis trial; MSFC: Multiple sclerosis functional composite ...
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Extracellular vesicles for acute kidney injury in preclinical rodent models: a meta-analysis
... marrow mesenchymal stromal cell (BMSC)-EVs [18, 27, 32, 40, 46–48], 6 used human umbilical cord mesenchymal stromal cell (UCMSC)-EVs [24, 28, 29, 36, 43, 44], 4 used human ...
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Heterologous mesenchymal stem cells successfully treat femoral pseudarthrosis in rats
... of mesenchymal stromal cell, respectively, that were extracted from bone marrow and marked with technetium-99 m radionucleotide (using the protocol of the Laboratory of Cell and Molecular ...
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Therapeutic prospects of extracellular vesicles in cancer treatment
... cells, these cargos can be transferred to neighboring cells and thus affect the processes occurring in those recipient cells and subsequently the tumor microenvironment as a whole. In addi- tion to their endogenous ...
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Stem cell technology for bone regeneration: current status and potential applications
... Abstract: Continued improvements in the understanding and application of mesenchymal stem cells (MSC) have revolutionized tissue engineering. This is particularly true within the field of skeletal regenerative ...
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Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata
... supplemented with antibiotics and centrifuged at 430 × g for 10 min (without brakes) to remove contaminating deb- ris and red blood cells. The wash step was repeated 2–3 times depending on the quality of the specimen. ...
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Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice
... adipose mesenchymal stromal cells; Ad-MSCs- SF: silk fibroin patch cellularized with human adipose-derived mesenchymal stromal cells; ADM: adipocyte differentiation medium; CB: cacodylate ...
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Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism
... marrow mesenchymal stromal cells; hucMSCs: human umbilical cord-derived mesenchymal stromal cells; EVs: extracellular vesicles; hucMSC-EVs: EVs derived from hucMSCs; PBS: phosphate buffer ...
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Finding a new therapeutic approach for no option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy
... (“replacement” cell therapy) but to reduce the consequences and the rate of neural cell deterioration by using MSC as a ...preserving cell homeostasis and maintaining a healthy microenvironment ...
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Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position
... stem cell therapy, specifically mesenchymal stem cells (MSCs), a multipotent stromal cell population, which have demonstrated promising data in multiple animal models of pulmonary fibrosis ...
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Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution
... increased endothelial stimulation. Given the scope of epitopes selected in this study, it seems that of the minor markers, the CD146 is necessary and sufficient to pro- vide for augmented paracrine support of endothelial ...
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