Mesenchymal stromal cell therapy
Mesenchymal stromal cell therapy attenuated lung and kidney injury but not brain damage in experimental cerebral malaria
... thus, our findings cannot be extrapolated to other models of malaria associated with different degrees of severity or to human malaria. Second, BM-MSCs were administered 1 day after infection, when the severity of ECM ...
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Mesenchymal stromal cell therapy in COPD: from bench to bedside
... MSC, mesenchymal stromal cell; NOD-SCID IL-2rg null mice, NOD/SCID/Il-2 receptor γ–chain null mice that lack an adaptive immune system, facilitating the successful ...
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Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients
... MSC therapy was tested in HLA-DR mis- matched patients with subclinical rejection (SCR) in their renal biopsy at 4 or 24 weeks after renal transplant- ation ...MSC therapy in cardiovascular disease have not ...
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Mesenchymal stromal cell therapy for Crohn's disease : from perianal fistulizing disease to experimental colitis
... cellular therapy with both adipose and bone marrow-derived MSC has been reported to be a safe, feasible and effective treatment for refractory perianal fistulizing ...
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Standardization of mesenchymal stromal cell therapy for perianal fistulizing Crohn's disease
... the techniques of administration, making it dif fi cult to reliably assess the effect of local therapy. Therefore, we sought to develop and test a standardized treatment pro- tocol. Although we have only validated ...
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Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells
... is a worthy example, an extract of it being used for the treatment of diabetes, diarrhea, menstrual pain, malaria, hematomas, hepatitis, hepatomas, and wound healing [35]. The proven ability of many herbal extracts to ...
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Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications
... identify cell types present in term amniotic fluid and as- sess their proliferation capacities, freshly isolated MNCs from eight samples were randomly chosen for plating in one, two, or all three culture media: ...
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Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay
... stem cell-based ...supporting cell types with all, or some, of these properties into ischemic tissue holds great prom- ...and mesenchymal stromal cells (MSCs) ...
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Umbilical cord as a long-term source of activatable mesenchymal stromal cells for immunomodulation
... Mesenchymal stromal cells (MSCs) are used in a variety of clinical trials for a plethora of diseases, due to therapeutic- ally relevant characteristics such as their differentiation po- tential, migration ...
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Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease
... IBD is a general term used to describe an idiopathic disorder that can be subdivided based on histopathology findings, i.e., granulomatous meningoencephalomyelitis (GME), necrotizing meningoencephalitis (NME), and ...
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Mesenchymal stem/stromal cell function in modulating cell death
... as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in preclinical studies and to some extent in clinical ...
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Mechanisms of mesenchymal stem/stromal cell function
... between stromal cells and breast cancer cells whereby stromal exosomes induced paracrine antiviral signals and stimulated juxtacrine Notch3 signaling that increased the number of therapy-resistant ...
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Human platelet lysate in mesenchymal stromal cell expansion according to a GMP grade protocol: a cell factory experience
... Mesenchymal stem/stromal cells (MSCs) represent one of the most promising tools in cellular therapy and regeneration. The increasing use of MSCs as ATMP has led to production processes that need to ...
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The quality evaluation system establishment of mesenchymal stromal cells for cell-based therapy products
... As outlined earlier in our study, our system only estab- lished a minimum set of standards for HUCMSCs, and there were some shortcomings due to the limited under- standing of the MSC mechanism of action in stem ...
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Adult human mesenchymal stromal cells and the treatment of graft versus host disease
... Mesenchymal stromal cells (MSCs) are multipotent adult cells capable of differentiating down multiple mesenchymal ...of Cell Therapy as: • adherence to plastic in ...
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Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up
... other cell types are used, in- cluding cells that are completely different to MSC, as the stromal vascular fraction ...different cell types, including some pro-inflammatory cells (as ...uniform ...
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Human cord blood-derived platelet lysate enhances the therapeutic activity of adipose-derived mesenchymal stromal cells isolated from Crohn’s disease patients in a mouse model of colitis
... ongoing studies aim at evaluating the optimal source, the proper dose, and the route of MSC administration. MSCs can be isolated and expanded from several tissues includ- ing bone marrow (BM), adipose tissue, and ...
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Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position
... for therapy other than ...stem cell therapy, specifically mesenchymal stem cells (MSCs), a multipotent stromal cell population, which have demonstrated promising data in multiple ...
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Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
... subjects. A full description of methods is provided as supplementary data (Additional file 1: Supplementary ma- terials and methods). Briefly, MSCs were derived from adi- pose tissue and proven to meet the International ...
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Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata
... the mesenchymal stem cells markers, but also the panhematopoietic/monocyte/macrophage/endothelial/ pericyte markers and particularly high levels of ...1). Cell viability, as assessed by Trypan blue and ...
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