metabolic dysregulation
Prohibitin: a prime candidate for a pleiotropic effector that mediates sex differences in obesity, insulin resistance, and metabolic dysregulation
... from metabolic dysregulation ...bolic dysregulation in mPHB-Tg mice is a conjoint mani- festation of adipose and immune-associated alterations [27, ...improved metabolic homeostasis, such as ...
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Dual role of B7 costimulation in obesity related nonalcoholic steatohepatitis and metabolic dysregulation
... hepatosteatosis/hepatosteatitis by concomitant antibody-mediated inhibition of both - B7.1 and B7.2 in DIO but not by inhibiting each one alone suggests a synergistic action of B7.1 and B7.2 to promote obesity-related ...
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Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
... to dysregulation of four metabolic pathways ...frail metabolic phe- notypes, Kruskal-Wallis analysis of variance with subsequent false discovery rate (FDR) testing for multiple comparisons was used ...
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Inflammation mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery
... Results: Immediately postoperatively, RA demonstrated markedly increased mRNA expression levels of cathepsin-L (7.5-fold, P < 0.05), FOXO1 (10.5-fold, P < 0.05), MAFbx (11.5-fold, P < 0.01), PDK4 (7.8-fold, P ...
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Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome
... In the pancreas, HGF/MET signaling is necessary for beta-cell regeneration [45]. A pancreas-specific knockout of the MET gene in mice accelerates the onset of diabetes [46]. Also, hepatocyte growth factor signaling is ...
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Early detection of metabolic dysregulation using water T<sub>2</sub> analysis of biobanked samples
... The comparison of frozen and fresh water T 2 values for 44 non-diabetic subjects revealed a high degree of correlation, but a lower degree of agreement. Water T 2 values for plasma and serum samples that had undergone ...
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Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation
... with metabolic dysregulation or inflammation develop asthma, suggesting that differences in genetic susceptibility may also underlie the development of pulmonary morbidity in only some obese ...
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<p>Identification of Transcriptional Metabolic Dysregulation in Subtypes of Pituitary Adenoma by Integrated Bioinformatics Analysis</p>
... various metabolic repro- gramming of tumors was performed using the published transcriptomics ...identifying metabolic-related genes and the mechanisms underlying PA ...
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Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways
... degradation metabolic pathways), and pronounced dysregulation of cellular energy ...whole-body metabolic dysfunction induced by a fungal skin infection, and these findings have broad relevance for ...
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Atherogenesis and metabolic dysregulation in LDL receptor–knockout rats
... The increase in VLDL levels and triglycerides in Ldlr-KO rats was asso- ciated with increased adiposity and progressive glucose intolerance (41). This increase in obesity and glucose intolerance has not been reported in ...
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Onion peel extracts ameliorate hyperglycemia and insulin resistance in high fat diet/streptozotocin-induced diabetic rats
... Conclusion: OPE might improve glucose response and insulin resistance associated with type 2 diabetes by alleviating metabolic dysregulation of free fatty acids, suppressing oxidative st[r] ...
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Search | Preprints
... neurological dysregulation affecting social and communicative skills, executive functioning, sensory gating, emotional awareness, theory of mind, memory formation and recall, integrating environmental and ...
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CASE-REPORT Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker.
... The patient’s peripheral blood leukocytes were used for gene expression testing. Testing included genes coding HSP, ILs, HSF-1, and NF-κB. Blood samples were taken from the ulnar vein to assess relative expression of ...
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The Mediating Role of Cognitive Flexibility, Shame and Emotion Dysregulation Between Neuroticism and Depression
... To examine whether the CFI, TOSCA- SHAME and DERS mediated the neuroticism-depression relation- ship, a total mediation model was evaluated. The mod- el’s fit was estimated (Figure 1), and Amos 22 was con- ducted for ...
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Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease
... circadian dysregulation that is associated with protein aggregation and with implications to magnesium/Sirt1 research and therapeutics in the regulation of α -synuclein/A β aggregates in the prevention of early ...
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Splicing dysregulation as a driver of breast cancer.
... 2017 Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival. Herzel L, Ottoz DSM, Alper[r] ...
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Dysregulation of autophagy and mitochondrial function in Parkinson’s disease
... Recent researches on PINK1/Parkin pathway have re- vealed molecular details for mitochondria protection. Once the mitochondria are impaired and the membrane potential gets depolarized, PINK1 will accumulate on the outer ...
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Congenital cystic adenomatoid malformations of the lung: an epithelial transcriptomic approach
... Our results indicate significant differences in gene expression between the epithelia of CCAM and healthy tissues. Dysregulated lung epithelium was re- cently suggested to play a key role in branching mor- phogenesis in ...
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BULIMIA NERVOSA INDIRECT SIGNS IN PATIENTS WITH DIABETIC DECOMPENSATION CASE REPORT
... some metabolic diseases if the origin of this dysregulation is psychosomatic but even if associated with a perceptual disorder, and a refusal by the patients recognize and accept their illness to which ...
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The role of epigenetic dysregulation in the epidemic of allergic disease
... changes in eicosanoid derivates and other metabolic products (resolvins; Calder 2009), oxidative cell membrane fluidity, surface marker expression (Calder et al. 2002) and cell signal transduction (Prescott et al. ...
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