metallothionein-I
Expression of Metallothionein in oral Leukoplakia
... and metallothionein (MT) is a protein that has been associated with carcinogenesis, this study could be auxiliary in this histological assessment of this ...of metallothionein in oral leukoplakia (OL) and ...
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Investigation of the Antioxidant Properties of Metallothionein in Transgenic Tobacco Plants using Voltammetry at a Carbon Paste Electrode
... At first we studied the ability of a reference MT standard to prevent the DNA destruction by the free hydroxyl radicals, OH • , created by the Fenton reaction. The influence of free oxygen radicals on DNA molecule ...
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Electrochemical Analysis of Metallothionein in Chicken Exposed to Cadmium Ions
... highest metallothionein levels were detected in the liver and kidney, which corresponded with cadmium accumulation determined by atomic absorption spectroscopy (68 µg/g liver tissue and 125 µg/g kidney tissue ...
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Expression, Characterization and Metallation Studies of Human Metallothionein Isoform 2a Using Electrospray Ionization Mass Spectrometry
... All living organisms utilize metals. Some metals such as iron (Fe), zinc (Zn), copper (Cu), magnesium (Mg) and cobalt (Co) are essential and are involved in a myriad of biological functions. 1-3 Metals such as lead (Pb), ...
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Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing?
... gesting a possible role of increased MT-I+II and III in neu- rodegeneration [27]. Moreover, the concomitant presence of MT isoforms provokes the atrophy of the pancreas in stressed mice [15]. Therefore, enhanced ...
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A Review of Metallothionein Isoforms and their Role in Pathophysiology
... MT- I&II was induced in mice fed with the Zn-L diet possi- bly compensating for Zn limitation that interact between dietary Zn and endogenous MT is important for maximal bone growth, and particularly important ...
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Renal effects of metallothionein induction by zinc in vitro and in vivo
... Background: Metallothionein (MTT) is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia. In kidneys, increased MTT expression exerts a putative protective role in diabetes and hypoxia. ...
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The role of metallothionein I/II in promoting axonal sprouting in both central nervous system and peripheral nervous system
... Immunohistochemical labeling using a MT antibody was performed upon tissue sections from either AlexaFluor-488 (vehicle) or the 488-MT injected animals. The MT labeling in the cortex receiving vehicle treatment did not ...
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Immune system modulation in the brain injury of the metallothionein I/II null mutant mouse
... Changes to the quantities of zinc in various compartments will affect zinc availability to various systems. The immune system is an important system that may be affected by zinc shifts after brain injury. For example, ...
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The role of metallothionein in zinc homeostasis
... protein, metallothionein (MT), consists of two metal-thiolate-clustered binding domains; the β-domain binds up to three divalent metals and the α-domain binds ...
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Anti-metallothionein IgG and levels of metallothionein in autistic children with GI disease
... Purified metallothionein-1 (Sigma, ...Excess metallothionein was dumped from wells and all wells were blocked by washing 3 × with 300 microliters of blocking solution (Superblock, Pierce Chemical ...to ...
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Interactions of Platinum-Based Cytostatics with Metallothionein Revealed by Electrochemistry
... protein metallothionein, because the overexpression of metallothionein in tumour cells belongs to the one of the generally accepted mechanisms of resistance to these ...
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Towards an Understanding of Specific Response of Metallothionein (Sub)Isoforms to Exposure to Platinum-Based Anticancer Drugs
... that MT 1, 2 and 3 expression manifested the highest qPCR activity after CisPt treatment (both healthy and cancer cells). We can also conclude that in principle, the platinum drug-induced overexpression of all ...
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Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome
... in metallothionein gene regulation. We show that metallothionein-I messenger RNA (mRNA) (mouse) and metallothionein-II mRNA (human) are elevated in mutant ...mouse ...
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Structural Motifs of Novel Metallothionein Proteins
... Metallothionein is a small cysteine rich protein, which was first isolated more than sixty years ago (1). In that time, it has been implicated in a number of roles, including toxic metal detoxification, metal ion ...
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Hydrodynamic Voltammograms Profiling of Metallothionein Fragment
... Metallothionein is intracellular metal binding protein. It can bind essential zinc ions and also toxic metals like cadmium. In cancer research the problem of resistance of cancer cells against anticancer drugs was ...
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Interferon-Mediated Immunopathological Events Are Associated with Atypical Innate and Adaptive Immune Responses in Patients with Severe Acute Respiratory Syndrome
... class I and II genes (human leukocyte antigens [HLAs]) and cell death regulators (BCL2- associated athanogene 1 [BAG1], BAG3, BAG4, and BAG5 genes) were generally downregulated throughout SARS ...
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High metallothionein predicts poor survival in glioblastoma multiforme
... MT s are negatively regulated by HIPK2 [13]. It was previously reported that, in HIPK2 knockdown colon cancer, breast cancer and ovarian cancer, p53 undergoes misfolding which inhibits DNA binding and transcrip- tional ...
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Identification of metallothionein gene structure in sterlet (Acipenser ruthenus)
... compounds. Metallothionein (MT) is one of that which represents a critical mechanism for detoxification of ...of Metallothionein of Sterlet, a cDNA encoding MT was purified from livers of sterlet, and the ...
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Prognostic significance of metallothionein expression in renal cell carcinoma
... Forty three consecutive patients, 31 men and 12 women, who underwent nephrectomy for RCC comprised the group of our study. Their age ranged from 33 to 85 years (mean age 59.6 ± 11.1). Tumors were histologically clas- ...
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