metronomic chemotherapy
Gene Expression Changes in Colorectal Cancer during Metronomic Chemotherapy and High Concentration Drug Administration
... strategies, metronomic chemo- therapy has recently demonstrated promising efficacy against otherwise chemoresistant neop- ...of metronomic applications in cancer stem cells are ...of metronomic ...
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Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort
... cyclophosphamide, 50 mg orally qod, etoposide, 50 mg orally qod, and gemcitabine, 1400 mg per body i.v. q2w for sarcoma. Rapa (2 mg) and HCQ (400 mg) treatments were started following the physician’s suggestion the ...
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A STUDY ON ADHERENCE PATTERNS, TOXICITIES AND QUALITY OF LIFE OF PATIENTS WITH PROGRESSIVE ADULT MALIGNANCIES ON METRONOMIC CHEMOTHERAPY
... “Metronomic” chemotherapy was coined by Douglas Hanahan as a new modality of drug administration for ...the metronomic therapy is to induce and maintain tumour dormancy (angiogenic dormancy), leading ...
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A novel multi drug metronomic chemotherapy significantly delays tumor growth in mice
... ronomic chemotherapy) has been shown to induce an antiangiogenic activity associated with strong anti-neo- plastic effects in absence of toxicity (reviewed in ...of metronomic chemotherapy have been ...
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Treatment Induced Acute Leukaemia after Major Response to Cyclophosphamide Based Metronomic Chemotherapy in Refractory Heavily Pre Treated Prostate Cancer
... Background: Metronomic chemotherapy is based on antiangiogenic and immunologic mechanisms obtained by the ad- ministration of traditional cytotoxic drugs at lower concentration without rest ...
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High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors
... of metronomic therapy on tumour progression, but also to highly improve the quality of life of pets affected by spontaneous malignant ...of metronomic chemotherapy, while alkalinizing approaches ...
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<p>Treating advanced breast cancer with metronomic chemotherapy: what is known, what is new and what is the future?</p>
... oral chemotherapy reduces the time and cost associated with treatment and is often more acceptable to patients than intravenous drug ...delivery. Metronomic administration of oral chemotherapy is ...
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Efficacy Study of Metronomic Chemotherapy in Metastatic Triple Negative Breast Cancer and Correlation with VEGF, TSP Levels
... Preclinical [3] [4] [5] and clinical studies [6] [7] [8] have established the bene- fits of metronomic chemotherapy in metastatic breast cancer. Oral chemothera- py drugs, used in our study—cyclophosphamide ...
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Impact of Metronomic Chemotherapy on Quality of Life in Recurrent, Residual and Metastatic Head & Neck Cancers
... Studies on QOL in recurrent or metastatic head and neck cancers are meagre. Most of the trials were conducted in radically treated head and neck cancers either post surgery or post Radiotherapy. With this background, the ...
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Low Dose Metronomic Chemotherapy in Metastatic Breast Cancer: A Retrospective Analysis of 40 Patients
... Low-dose metronomic chemotherapy is an emergent treatment schedule in which low doses of cytotoxic agents are given orally continuously, with no or short drug-free ...of chemotherapy after receiving ...
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A pilot study of a metronomic chemotherapy regimen with weekly low-dose docetaxel for previously treated non-small cell lung cancer
... not always serve as surrogate markers for determining the OBD in LDM chemotherapy. However, LDM chemotherapy could also promote the differentiation of tumor cells. Eckert et al and Grünberg et al observed ...
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Kubisch, Rebekka (2013): Mechanism of cancer evading metronomic chemotherapy and action of Archazolid as an anti-metastatic drug. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Cells developing resistance to metronomic cyclophosphamide (CPA) therapy undergo a complex molecular evolution. Changes in many different factors and pathways contribute to the formation of a resistant phenotype. ...
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The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients
... decade, metronomic chemotherapy has been proposed as an alternative to conventional drug adminis- tration in cancer ...patients. Metronomic administration comprises 3 characteristics: (1) it is ...
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Click here to download PDF version of the article !
... newer metronomic chemotherapy regimen which showed convincing results in various experimental studies and paved to begin cancer trials with metronomic ...with metronomic regimen probably due ...
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PubMedCentral-PMC5491115.pdf
... Metronomic chemotherapy is defined as a chronic, uninterrupted, low dose administration of chemodrugs ...conventional chemotherapy, where chemodrugs are administered in cycles of maximum tolerated ...
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Pilot study of a pediatric metronomic 4-drug regimen
... receiving metronomic chemotherapy [3, 4, 5, 24], this type of therapy may more likely lead to tumor stabilizations [3, 4, 7, 10, ...as metronomic treatments, which are less likely to produce tumor ...
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Oral metronomic vinorelbine combined with endocrine therapy in hormone receptor positive HER2 negative breast cancer: SOLTI 1501 VENTANA window of opportunity trial
... Metronomic chemotherapy schedule seems to have not only a direct cytotoxicity on cancer cells but also an effect on the tumor microenvironment by modulating immune response ...with metronomic ...
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Mathematical model of cancer growth controled by metronomic chemotherapies*
... thus requires prolonged breaks (generally of 2-3 weeks in duration) between successive cycles to allow recovery from the harmful side effects but also time for cancer tissue to eventually resume growth. Moreover, in the ...
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A Commentary: Herbal Medicine Offers Great Potential in Support of Metronomic Cancer Therapy
... results. Metronomic Chemotherapy: Attention on the use of old oral cytotoxic drugs in small doses for refractory and late cancer cases has started more than a ...tronomic chemotherapy, combined with ...
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Serum levels of VEGF and MCSF in HER2+ / HER2- breast cancer patients with metronomic neoadjuvant chemotherapy
... of metronomic chemotherapy in combination with antiangiogenic agents could be an attractive strat- egy, although complicated by the fact that bevacizumab has failed clinical trials in the adjuvant setting ...
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