MHC class II molecule
The diabetogenic mouse MHC class II molecule I Ag7 is endowed with a switch that modulates TCR affinity
... specific MHC alleles. Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-A g7 , typically have a small, uncharged amino acid residue at position 57 of their b chain (b57); ...
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Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
... the MHC class II molecule of the NOD mouse, and, after intranasal administration, induces regulatory CD4 + T cells that, in the absence of CD8 + T cells, block the adoptive transfer of ...
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Foal Monocyte-Derived Dendritic Cells Become Activated upon Rhodococcus equi Infection
... in MHC class II expression between infected and noninfected mMOs and ...higher MHC class II molecule expression is a major factor that indicates mDC dif- ferentiation and ...
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Characterization of a Phenotypically Unique Population of CD13+ Dendritic Cells Resident in the Spleen
... expressing MHC class II molecules and then to remove those other cell subsets that also express MHC class II molecules: monocytes, macrophages, B lymphocytes, ␣ T lymphocytes, ...
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The interaction of HLA-DM with conventional MHC class II molecules
... s II e n c o d e d “ n o n - c l a s s i c a l ” heterodim eric molecule, form ed a very stable com plex with HLA- DM in Hela-transfectants and needed DM in order to leave the ER and be ta rg e te d to the ...
293
The specific T-cell response to antigenic peptides is influenced by bystander peptides
... of MHC class I and class II molecules are loaded with foreign antigenic peptides; the vast majority are loaded with thousands of different self ...that MHC molecules presenting self ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... with MHC class I and class II have been previously described ...co-stimulatory molecule. The associations of CD81 with MHC molecules have been described ...the MHC and ...
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Varicella-Zoster Virus Productively Infects Mature Dendritic Cells and Alters Their Immune Function
... with MHC molecules but also on the interaction with several other immune molecules in- cluding CD40, CD54, CD80, CD83, and CD86 (23, 28, ...of MHC class I, MHC class II, CD80, ...
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Interferon gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts
... increased MHC class II molecules, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 compared to normal or isografted ...of MHC antigens and leukocyte ...
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Presentation of intracellular antigen with MHC class II molecules
... investigated class II presentation of influenza haem agglutinin (HA) transport m utants in B ...the molecule is relatively stable w ith a half-life of 4-6 ...This molecule does not reach the ...
235
Co-culture of primary human tumor hepatocytes from patients with hepatocellular carcinoma with autologous peripheral blood mononuclear cells: study of their in vitro immunological interactions
... of MHC II (activation) on PBMCs from patients with HCC after isolation was ...of MHC II expression in co-culture with HCC as compared to non-HCC hepatocytes at all time ...Although, MHC ...
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Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system
... delivers the second signal upon binding to costimulatory molecules CD80 and CD86 [30]. The expression of cost- imulatory molecules is largely restricted to professional antigen-presenting cells such as dendritic cells ...
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Counterregulatory effects of interferon gamma and endotoxin on expression of the human C4 genes
... decreases monocyte C4 expression and completely abrogates the effect of IFN-gamma on the expression of this gene. In contrast, LPS and IFN-gamma have a synergistic effect in upregulating expression of another ...
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Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation
... complex class II (MHC-II) alleles encoding molecules that foster the survival of Bd-infected ...the MHC-II antigen- binding ...of MHC-II pocket 9 of surviving ...
9
The systems biology of MHC class II antigen presentation
... While MHC-I binds peptides in a partially folded state stabilized by chaperones in the ER, this is probably different for MHC-II, as endosomes are not known to contribute to ...of ...
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Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma
... express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC ...the class I and class II MHC ...
10
Tumor-specific CD4 T cells eradicate myeloma cells genetically deficient in MHC class II display
... Trichostatin A at the indicated concentrations. (B) mRNA expression of the Air-1 gene in MOPC315 or J558 cells treated as in (A), plotted relative to expression in J558 cells treated with 10 nM Trichostatin A (fold ...
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Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
... (LAD II) is caused by deficient expression of sialyl Lewis X determinants, the neu- trophil ligands for E- and ...LAD II present with less severe infections than LAD I patients, along with developmental ...
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MHC class II-restricted T cell responses to flaviviruses
... Further, when the class II antigens from resting and activated B cells were incorporated in artificial planar membranes they showed a similar capacit'y to present ovalbumin peptides to s[r] ...
243
Designing of interferon-gamma inducing MHC class-II binders
... The performance of the SVM based models increases after adding a feature of length along with compositional vector. This may be co-related with the earlier report of variation in affinity of MHC-peptide binding ...
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