MiaPaCa-2
Latexin inhibits the proliferation of CD133+ miapaca 2 pancreatic cancer stem like cells
... lines miapaca-2 and patu8988 were purchased from the American Type Culture Collection (ATCC; Manassas, VA, ...line miapaca-2 were isolated by magnetic activated cell sorting ...7 ...
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Inhibitory effect of (−)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth
... cancer [41]. EGCG has antioxidant activities and re- solved inflammation during BLM induced pulmonary fibrosis [42]. BLM is clinically used for cancer therapy [21]. BLM plays both central and coordinated roles in a ...
7
Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer
... and MiaPaCa-2 PCA cells were obtained from a qualified source (American Type Culture Collection, Rockville, MD, ...USA). MiaPaCa-2 PCA cells were transgenetically modified to carry the ...
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Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer
... and MiaPaCa-2 cells) and in vivo (clinically translat- able residual PC mouse model) approaches coupled with clinically relevant fractionated radiation dose regimens, recognize the activation of autophagy ...
17
<p>Downregulated expression of RACK1 results in pancreatic cancer growth and metastasis</p>
... in MiaPaca-2 and Panc-2 cells. (B) racK1-silent MiaPaca-2 and BXPc-3 cells had enhanced reporter activity of nF-κB ...in MiaPaca-2 and Panc-2 ...of ...
14
Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells
... MAPK signaling pathway has been shown to play essential roles in the regulation of a wide variety of cellular processes, including cell growth, cell cycle regulation, migration, differ- entiation, development, and ...
10
DEPTOR has growth suppression activity against pancreatic cancer cells
... Given the observation that DEPTOR expression was lost in PDAC tissues, we next determined whether ectopic DEPTOR expression would affect the growth of pancreatic cancer cells. We transfected FLAG-tagged DEPTOR cDNA, ...
9
Induction of Apoptosis and Anoikis by Bit1 in Pancreatic Cancer Cells
... lines, Miapaca-2 and PANC-1, in- duced caspase-independent apoptosis while exogenous expression of mitochondrial-localized Bit1 in these cells attenuated their anoikis resistance and enhanced their ...
10
MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells
... BxPC3, MiaPaCa‑2 and Panc‑1 cells suppressed the cell inva‑ sion and colony formation ability, and the expression level of Ang‑2 protein in MiaPaCa‑2 and Panc‑1 cells was also ...
9
Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis
... PanIN is a histologically well-defined precursor to invasive PDAC, associated with active Kras mutations [20]. Previously study has demonstrated that PRR expression was barely detectable in normal pancreatic ducts, but ...
12
Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation
... To investigate the effects of the antagonism of EP2/ EP4-mediated cellular signaling on growth factor receptor- mediated growth stimulation, we treated cells with EP2/EP4 antagonists, i.e., AH6809/GW627368X, and assessed ...
16
Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302
... Because hypoxic tumors are poorly prognostic and resist- ant to chemo- and radiotherapies, there has been intense interest in agents that will target hypoxic volumes. HAPs are a new class of anti-cancer therapeutics, and ...
13
Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer
... Abstract: Current therapies for the treatment of pancreatic cancer are limited. The limitations of this type of treatment are abundant. The majority of chemotherapeutic agents used in clinics are highly toxic to both ...
10
Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer
... To characterize the heightened stemness of PC-CSCs that survive radiotherapy, we examined the modulations in 93 stem cell-related molecules in ALDH + CD44 + CD24 + PC- CSCs that were derived from the xenografts ...
14
Ezrin promotes invasion and metastasis of pancreatic cancer cells
... fibers, which in turn increases cell motility by changing actin dynamics and decreasing of cell adhesion [29]. The PI3-kinase pathway has also been shown to be responsi- ble for RAC-dependent membrane ruffling downstream ...
14
Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo
... Six- to eight-week-old BALB/c homozygous (nu/nu) nude mice (18–20 g body weight) were purchased from Shanghai SLAC Laboratory Animal Co., Ltd. (Shanghai, People’s Republic of China). The mice were maintained in a ...
12
Gene Expression Comparison Between the Lymph Node-Positive and Negative Reveals a Peculiar Immune-microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study
... of XAV-939 on two PDAC cell lines, PANC-1 and MIAPaCa-2, by CCK-8 proliferation assay.. The cell proliferation (%)/dose plots of the mean of 189.[r] ...
25
6,10,16,19 Tetraoxatrispiro[4 2 2 4 2 2]nonadecane
... C3 0.052 (2) 0.053 (2) 0.0460 (17) −0.0121 (17) 0.0100 (15) −0.0008 (16) C4 0.057 (2) 0.052 (2) 0.061 (2) 0.0252 (18) −0.0165 (17) −0.0025 (17) C5 0.0338 (14) 0.0256 (15) 0.0413 (15) ...
7
eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells
... Figure 3: overexpressed eIF3f inhibits cancer cell proliferation and induces apoptosis. The same number of HeLa A. and BxPc-3 b. cells were plated in triplicate in 96-well plates. The O.D value of cells was then measured ...
17
(Z) 2 (2 Methoxybenzylidene) 1 azabicyclo[2 2 2]octan 3 one
... N1 0.0239 (14) 0.0163 (13) 0.0223 (18) −0.0008 (11) −0.0015 (13) −0.0004 (13) C1 0.0190 (16) 0.0107 (13) 0.0216 (19) −0.0017 (12) 0.0000 (15) −0.0001 (16) O2 0.0229 (11) 0.0234 (11) 0.0257 (13) 0.0002 (9) 0.0006 (12) ...
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