Microglia/macrophage
Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury
... and microglia/macrophage activation in the far-away hematoma were closely associated with phago- cytosis, as indicated by morphological observation that TLR4 immunoreactive product was located within the ...
15
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice
... of microglia and macrophages. Although microglia and macrophages displayed similar responses in the presence of dead/dying neurons, differences in their STAT6 expression and functions were ...on ...
21
Phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation combined with ultrasound for breaking through the blood–brain barrier
... is very important [3]. However, neuronal damage is primarily due to not only an acute occlusion of cerebral vessels but also ischemic reperfusion (IR) after thrombo- lytic therapy, which may induce complex inflammatory ...
10
CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke
... proliferating microglia cells and recruitment of monocytes, associated with CX3CR1 deficiency, resulted in a significant decrease in the levels of IL-1β, TNF-α, and IL-6, suggesting an important tem- poral ...
13
Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
... of microglia but not CNS-infiltrating ...from microglia and likely respond to injury ...that microglia become activated, then surround, and con- fine infiltrating ...of microglia allows for ...
16
Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion
... other macrophage populations outside the bone has been barely ...other macrophage populations is the low concentration of ZA outside the ...influences microglia, the resident macrophage-like ...
12
Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation
... M2 microglia, cells that show neuroprotective and regenerative properties in the CNS [27, 44], co-localizing with the M2 macrophage/ microglia marker P2Y12R ...M2 microglia cells induces ...
14
Understanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection
... of macrophage morphology and function may in part, be governed by the cells in the microenviron- ment with which macrophages ...of macrophage found in the intestine, the muscu- laris macrophages, associate ...
8
Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress
... in microglia derived from female Het mice, a model that more closely mimics clinical RTT, which occurs in ...in microglia from pre-phenotypic female RTT ...
12
Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
... Immunohistochemistry was performed on 20- μ m brain coronal sections using anti-mouse CD11b (1:700, kindly provided by Dr. Doni, [8] anti-mouse-CD45 (1:800, BD Biosciences Pharmigen, San Jose, CA), anti-mouse CD68 ...
20
Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia
... Together with our previous observation that AMWAP inhibits NFκB-dependent CCL2 promoter activity [14], these findings prompted us to study the direct influence of AMWAP on microglial NFκB activation. Exogenous AMWAP was ...
14
Bee venom acupuncture reduces neuroinflammation modulating microglia/macrophage phenotype polarization in spinal cord injury compression model
... the complexity of the phenotypic polarization that microglia and macrophages can acquire [18,21,25] . In SCI, Figure 5. Influence of apipuncture on NeuN and CNPase levels in the spinal cord 7 days after SCI. In A: ...
13
Dynamic response of microglia/macrophage polarization following demyelination in mice
... system, microglia/macrophages (M/M) play a central role in neu- roinflammation by antigen presentation, phagocytosis of apoptotic cells and cellular debris, as well as by the pro- duction of cytokines, chemokines, ...
22
Neurocognitive and neuroinflammatory correlates of PDYN and OPRK1 mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects
... (PDYN), macrophage scavenger receptor CD163, and microglia/macrophage marker CD68 in the caudate and anterior cingulate of postmortem brains from HIV-positive and HIV-negative ...
8
Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain
... and macrophage (tomato lectin (TL) C – D)/microglia (Iba-1; E, F) in PBS-treated animals (A, C, and E) and sildenafil 10 mg/kg (B, D, and F) at 72 h (A – D) and 8 days (E, F) after pMCAo in mouse ...and ...
12
Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice
... Spontaneous intracerebral hemorrhage (ICH) is a common fatal stroke subtype that accounts for 10 to 15% of all stroke cases and associated with high mortality and morbidity [1]. The hematoma formation and its expansion ...
13
M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia
... C/EBPβ plays numerous roles in activation and differen- tiation of macrophages [57]. It has been reported to have a role in inflammatory processes in rodents [58-60] and may play a role in differentiated ...
15
Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat
... tissue macrophage/microglia activation (CD68 + ...tissue macrophage/ microglia activation in hypertensive and normotensive RGC projection sites in the SCs compared to a naïve ...astrocytes, ...
16
Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks
... and microglia to investigate the role of open chromatin sites containing motifs for specific transcription ...specific macrophage and microglia transcription factor motif-containing open chromatin ...
10
Selective targeting of microglia by quantum dots
... which microglia take up QDs, cortical cultures were pre- treated with chlorpromazine (CPZ) (6-20 μ M), cytochala- sin B (CTB) (4-8 μM), bafilomycin (BAF) (25-50 nM), mannan (1-2 mg/ml), polyinosinic acid (100-200 ...
13