Microglial cell
Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
... novel cell line using microglia purified from the adult mouse ...promote microglial cell growth [17, ...adult microglial cells (CD11b and F4/ ...
15
Prevention of methamphetamine-induced microglial cell death by TNF-α and IL-6 through activation of the JAK-STAT pathway
... on microglial TNF- α and IL-6 systems, we further aimed to clarify the role played by such cytokines under conditions of METH-induced cell ...affect microglial cell death induced by METH, ...
14
Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein
... We use BV-2 microglial cell line and the primary rami- fied microglia in the mixed glial culture as an experimen- tal platform. We study the effects of C. cochinchinensis on the therapeutic potential of ...
11
A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease
... of microglial biology has also become apparent, leading to a heightened research interest in this particular cell ...different microglial cell culturing techniques have been developed to study ...
8
Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD
... Consistent with the GVHD-mediated upregulation of IDO-1, we observed that levels of the IDO- 1 metabolite, kynurenine, were significantly increased in mice with GVHD in the mPFC and DRN. Conversely, kynurenic acid, which ...
18
Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord
... affected cell types. BrdU incorporation studies reveal that reduced cell proliferation is an important factor underlying NG2- dependent decreases in each of the three key cell ...macrophage/ ...
13
Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats
... After recirculation, microglial cell activation was immuno-histochemically studied using anti-Iba1 anti- body (Figure 3). Day2 post-recirculation, Iba1+ cells in the entire hippocampus were slightly ...
10
AN ANIMAL MODEL TO ASSESS THE EFFECTS OF HYDROXYUREA EXPOSURE SUGGESTS THAT THE ADMINISTRATION OF THIS AGENT TO PREGNANT WOMEN AND YOUNG INFANTS MAY NOT BE AS SAFE AS WE THOUGHT Lucía Rodríguez-Vázquez aand Joaquín Martí a,*
... Figure 2. (A) TUNEL positive cells in the cerebellar external granular layer (white arrows) from a rat administered with hydroxyurea in the perinatal life. (B) Thin plastic section (0.5 µm) from a rat cerebellum ...
26
Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol
... inflammatory cell signaling molecules (p-38 MAPK, M; p-JNK, N; p-AKT, O; and NF- κ B, ...pro-inflammatory cell signaling molecules in microglia, but naltrindole failed to alter ethanol ...the ...
19
Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptidesi
... Primary microglial cell culture and microglial cells lines Primary microglial murine cell cultures were prepared as previously described in detail (Hanisch et ...
13
Time-dependent effects of hypothermia on microglial activation and migration
... wound, microglial cell migration was assessed by measur- ing wound closure at the end of a 24 to 48 hour incuba- tion ...in cell proliferation was observed between normothermia and hypothermia con- ...
22
Microglial dynamics after axotomy-induced retinal ganglion cell death
... 3 Microglial cell morphologies, quantitative topography, and correlation analyses of PMC appearance, RGC clearance, and RGC ...a Microglial cells in control or axotomized retinas: magnifications from ...
15
Microglia in the Cerebral and Cerebellar Cortices in Individuals with Autism
... that microglial cell bodies are relatively stationary, but their fine processes are in constant motion on a minute-to- minute ...the microglial processes continually probe the immediate area, so that ...
161
CXCL10 Production from Cytomegalovirus-Stimulated Microglia Is Regulated by both Human and Viral Interleukin-10
... in microglial cells. CMV binding to the host cell surface is known to activate signaling molecules and transcription factors, such as p38 MAP kinase and NF-B (57), in various cell types (24), ...
14
Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice
... of microglial morphology and phenotypic alterations in response to the application of IL-4 applied exogenously were assessed using the immortalized murine microglial cell line, ...BV2 ...
13
MUTYH promotes oxidative microglial activation and inherited retinal degeneration
... photoreceptor cell death due to genetic mutations; however, an accumulating body of evidence suggests that chronic inflammation may contribute to the progression of rod and cone degeneration in ...patients, ...
16
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury
... [22-29]. Microglial cell gp91 phox appears to be involved in the induction of neuronal damage in Parkin- son’s disease, Alzheimer’s disease, and ischemic stroke ...the microglial phenotypes expressed ...
11
Expression of mutant alpha-synuclein modulates microglial phenotype in vitro
... lates microglial phenotype, the murine microglial cell line, BV2, [31] was selected as an in vitro model of microglia because it is amenable to transient transfection for exo- genous gene ...
12
The role of microglial P2X7: modulation of cell death and cytokine release
... mediates cell death in microglia P2X7 mediates ATP-induced cell death in different cell types including macrophages and T lymphocytes [22, ...guiding microglial fate, we used P2X7 −/− mouse ...
13
Methamphetamine neurotoxicity, microglia, and neuroinflammation
... We understand the term “neurotoxicity” to mean that METH exposure is directly toxic to neurons, but not ne- cessarily in the sense that METH kills neurons. Dopa- minergic neurons are of particular interest because METH ...
6