MicroRNA-125b
Original Article Circulating microRNA-125b expression predicts clinical response in patients with rheumatoid arthritis treated by tumor necrosis factor inhibitors
... Abstract: This study was aimed to investigate the correlation of serum microRNA-125b (miR-125b) expression and clinical response to tumor necrosis factor inhibitors (TNFi) in RA patients. 89 moderate ...
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Original Article Association of serum microRNA-125b and HBV-related hepatocellular carcinoma in Chinese Han patients
... Serum microRNA- 125b has been used to predict microvascular invasion in hepatocellular carcinomas patients, which might provide a powerful tool in making an accurate diagnosis of microvascular inva- ...
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Good guy or bad guy: the opposing roles of microRNA 125b in cancer
... miRNA: microRNA; miR-125b: microRNA 125b; MMP13: Matrix metalloproteinase; mTOR: Mammalian target of rapamycin; p21: cyclin dependent kinase inhibitor 1; p53: tumor suppressor gene p53; PIGF: ...
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MicroRNA 125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis
... Background: MicroRNAs (miRNAs) are small RNAs that regulate gene expression by targeting mRNA. It was proved that some miRNAs are significantly deregulated in rheumatoid arthritis (RA). MicroRNA-125b ...
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MicroRNA 125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer
... ERα ligands, regulated by ERα, regulating ERα, dere- gulated in breast cancer or deregulated in endocrine re- sistance) [16,42] (Figure 2, miRNAs with a red asterisk). In the only study in which miRNA expression profiles ...
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Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA 125b
... It has been demonstrated miR-125b expression was down-regulated in HCC, which is the prediction of ag- gressiveness and poor prognosis of HCC [33]. In this study, we found that miR-125b was implicated in ...
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MicroRNA-125b promotes tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer
... including STARD13, ZNF792, SH3TC2, IRF4, FUT4, BAK1, ARID3B, and TP53INP1 for real time PCR anal- ysis. We found that the expression of TP53INP1 exhib- ited a dramatically elevation in NSCLC cells transfected with ...
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Original Article Anti-tumor effect of piceatannol through induction of cell apoptosis via up-regulation of microRNA-125b expression on pancreatic cancer
... SYBR Green PCR Kit which contained 10× miS- cript Universal Primer (Qiagen) and was per- formed according to the manufacturer’s proto- col. Quantization of U6 was used to normalize miRNA expression level. Real-time PCR ...
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Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma
... presented. (B) Combination therapy with doxorubicin and AZ505 in a renal cancer subcutaneous xenograft model. (a) Representative images of the tumors isolated from the mice in each treatment group. (b, c) Tumor volumes ...
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Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma
... It is reported that miRNAs play significant role in EMT [38]. MiRNAs are small non-coding RNAs that regulate gene expression by binding to the 3’-UTR of the target mRNA and inhibiting translation or targeting the mRNA ...
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Original Article MicroRNA-125b protects hyperglycemia-induced, human retinal pigment epithelial cells (RPE) from death by targeting hexokinase 2
... Abstract: Diabetic retinal disease (DR) is the main cause of visual disability and blindness in adults with diabetes mellitus. Currently, efficient prevention and treatment are still under investigation. MicroRNAs ...
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Review Article Prognostic role of microRNA 125b invarious cancers: a meta-analysis
... Eligible studies included in this meta-analysis according to the following criteria: (1) it report- ed miR-125b expression by the specific meth- ods in tumor tissue or blood; (2) it invested the association ...
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MicroRNA 125b regulates the expression of aggrecanase 1 (ADAMTS 4) in human osteoarthritic chondrocytes
... pre-miR- 125b-1 (encoded on chromosomes 11) (uc010rzr.1) and pre-miR-125b-2 (encoded on chromosomes 21) ...miR- 125b-2 mutation1 Forward;TCTACCGCATCAAACCA- GACTTTTCCTAGtgGG tgTCACCCTAACTTGTGA ...
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MicroRNA-125b exerts antitumor functions in cutaneous squamous cell carcinoma by targeting the STAT3 pathway
... MiR-125b has been reported to act as a tumor repressor or promoter [25]. For example, miR-125b shows reduced expression in ovarian cancer, but is overexpressed in colorectal tumors [26, 27]. Xu et al. ...
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RETRACTED ARTICLE: Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression
... Accumulating evidence suggests that microRNAs (miR- NAs) play important roles in post-transcriptional regula- tion of oncogenes. This prompted us to investigate whether loss of miRNA facilitated the up regulation of ...
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miR-125b induces cellular senescence in malignant melanoma
... We have previously shown by miRNA array approach that miR-125b is expressed in primary cutaneous MM [26,41]. By comparing metastasizing and non-metastasizing stage T2 cutaneous MM we detected an overall decrease ...
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<p>The Emerging Roles of miR-125b in Cancers</p>
... The decrease in miR-125b expression in breast cancer may be due to the enhancement of DNA methylation in the promoter region. 52 Downregulation of miR-125b induces cell survival by inducing the expression ...
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<p>The proliferation of cervical cancer is promoted by miRNA-125b through the regulation of the HMGA1</p>
... To evaluate the distinctiveness of miR-125b within CC in clinical practice, 112 volunteers were divided into two teams in accordance with miR-125b expression levels, and the median expression level was used ...
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Involvement of methylation of MicroRNA-122, −125b and -106b in regulation of Cyclin G1, CAT-1 and STAT3 target genes in isoniazid-induced liver injury
... DILI pathogenesis usually involves parent compounds that become hepatotoxic through metabolism, oxidative stress, lipid peroxidation, mitochondrial dysfunction, apoptosis and immune response [43]. A growing body of ...
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Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer
... ingly, MicroRNA-BD has been developed to discover miRNA biomarkers by considering the single-line regu- latory power (measured by NSR) and the tendency to regulate transcription factor gene (measured by TF gene ...
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