Microsomal triglyceride transfer protein (MTTP)
Supplementary site interactions are critical for the regulation of microsomal triglyceride transfer protein by microRNA-30c
... Microsomal triglyceride transfer protein (MTTP) is an essential chaperone that assists in the assembly of apolipoprotein B-containing lipoproteins to transport ...regulates MTTP ...
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Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China
... [4]. Microsomal triglyceride transfer protein (MTP, or MTTP) is a heterodimeric lipid transfer protein mainly present in hepatocytes, enterocytes and myocytes which ...
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Inhibition of hepatic microsomal triglyceride transfer protein – a novel therapeutic option for treatment of homozygous familial hypercholesterolemia
... the microsomal triglyceride transfer protein ...the transfer of triglycerides into very low density lipoprotein particles, the drug blocks their assembly and secretion into the ...
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Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue specific knockout mice
... in microsomal triglyceride transfer protein (MTP) causes the human lipoprotein deficien- cy syndrome ...“floxed” Mttp allele and then used Cre-mediated recombina- tion to generate ...
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Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function
... in microsomal triglyceride transfer protein ...lipid transfer onto apolipoprotein B (APOB) and impaired secretion of APOB-containing ...
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Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus
... the MTTP -493G ⁄ T SNP by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) ...prevalent MTTP -493G/T genotype was GG (46%) followed by GT ...the MTTP -493G ⁄ T SNP in ...
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Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP)
... cholesterol, triglyceride and apolipoprotein B (apoB) compared to patients chroni- cally infected with other HCV genotypes, suggesting a profound alteration in lipid and lipoprotein metabolism in infected ...
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Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women
... The microsomal triglyceride transfer protein (MTP) is a heterodimeric lipid transfer protein mainly present in hepatocytes and entero- ...to transfer cholesterol esters ...
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Functional Comparison of High and Low Molecular Weight Chitosan on Lipid Metabolism and Signals in High-Fat Diet-Fed Rats
... AMP-activated protein kinase (AMPK)α and peroxisome proliferator-activated receptor (PPAR)α protein expressions and the increased lipogenesis/cholesterogenesis-associated protein expressions (sterol ...
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New targets and developments in lipoproteins control
... or microsomal triglyceride transfer protein [MTP] inhibition) or proprotein convertase subtilisin/kexin type 9 (PCSK9) blockers, all decrease low-density lipoprotein (LDL) ...ester ...
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Role of the haem oxygenase pathway in protection against vascular dysfunction
... glycerol; 0.4 % (w/v) bromophenol blue; 0.4 % (w/v) xylene cyanol; 1 mM EDTA) was added. Samples (10-20 pg RNA/lane) were loaded on a 1.3 % (w/v) denaturing agarose gel (1.3 g agarose-LE (Ambion Inc., Austin, Texas, ...
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Characterization of Two New Structural Glycoproteins, GP3 and GP4, of Equine Arteritis Virus
... Nothing is known about the significance or function of the EAV ORF3 and -4 products, except that both are essential in the viral life cycle. When the expression of these ORFs was separately blocked by mutagenesis with a ...
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Bioluminescence Resonance Energy Transfer System for Measuring Dynamic Protein Protein Interactions in Bacteria
... ABSTRACT Protein-protein interactions are important for virtually every biological process, and a number of elegant approaches have been designed to detect and evaluate such ...real-time ...
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Human ApoA II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice
... prepared from mice of various genotypes showed inhibition of emulsion-based hepatic lipase activity in proportion to the apoA-II/apoA-I ratio of HDL. The presence of human apoA-II also inhibited mouse plasma hepatic ...
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The chylomicron: relationship to atherosclerosis
... B48 in the plaque [114]. These findings have been confirmed in humans by other workers [115]. The mechanism whereby the macrophage takes up the chylomicron particle has been extensively investigated. The chylomicron ...
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Molecular characterization of Tunisian families with abetalipoproteinemia and identification of a novel mutation in MTTP gene
... Many mutations in MTTP gene described in literature as cause of ABL were private and related to single families. There was an exception with (p.G865X) muta- tion which was found in ABL patients from USA and Canada ...
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INTERCROPPING OF AYURVEDIC HERBS USEFUL IN THE MANAGEMENT OF DIABETES- A LIFESTYLE DISEASE
... bengalensis bark on blood glucose, serum electrolytes, serum glycolytic enzymes, liver microsomal protein, hepatic cytochrome P-450 dependent monooxygenase enzymes and lipid peroxid[r] ...
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Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects
... by insulin as suggested by a study in China relating lipo- protein lipase, vitamin D and insulin resistance [24]. In fact, insulin sensitivity likely explains the role of insulin on plasma HDL-C concentration ...
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Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas
... collected from medical records. Eligible preeclamptic cau- casian race pregnant women have been diagnosed with preeclampsia according to the following criteria: presence of pregnancy-induced hypertension (systolic ≥140 ...
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Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.
... Canine pancreatic microsomal membranes have been used to study glycosylation of proteins in vitro; translation in rabbit reticulocyte lysates containing microsomal membranes can result i[r] ...
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