Mimetic Peptide
Immunological Evidence for Functional Rather than Structural Mimicry by a Shigella flexneri Y Polysaccharide-Mimetic Peptide
... a peptide mimic of the Shigella flexneri Y O polysaccharide (PS), with an anti-carbohydrate monoclonal antibody, as studied previously by X-ray crystallography, suggested the presence of functional rather than ...
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The Gamma Interferon (IFN-γ) Mimetic Peptide IFN-γ(95-133) Prevents Encephalomyocarditis Virus Infection both in Tissue Culture and in Mice
... IFN-␥ peptide IFN-␥(95-133) possesses IFN-␥ agonist activity, such as induction of major histocompatibility complex class II molecules (2, 21, 22) without toxicity, on ...this mimetic peptide ...
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The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit
... apoA-I mimetic peptides that are much shorter in length (18-22 peptides) and able to be readily synthesized on a large scale, but still exhibit the same beneficial properties as HDL and full-length apoA- ...of ...
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A Double-Mimetic Peptide Efficiently Neutralizes HIV-1 by Bridging the CD4- and Coreceptor-Binding Sites of gp120
... CCR5-mimetic peptide CCR5mim2 ...both mimetic pep- tides are engaged, likely to the same gp120 ...both mimetic peptides alone, each at the same total concentration as 16-Fc, neutralized HIV-1 ...
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An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration
... Lecithin cholesterol acyltransferase (LCAT) plays a key role in the reverse cholesterol transport (RCT) process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in turn deliver ...
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Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH
... apoE mimetic peptide CN-105 reduces histological evidence of vaso- spasm and has a durable effect on improving functional and histological outcomes following ...
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A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies
... sulfo- peptide to its C ...coreceptor-mimetic peptide improves the potency of broadly neutralizing antibodies (bNAbs) targeting five ma- jor epitopes on the HIV-1 envelope glycoprotein ...
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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI
... (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for athero- protection remains ...of mimetic peptides to ...
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Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT−/− mouse model of preeclampsia
... A1 mimetic peptide, functions as an anti-inflammatory agent; ABCA1 functions as an anti-inflammatory receptor to suppress the expression of inflammatory factors and to be the molecular basis for the ...
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Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis
... Based on our previous results, described above, we chose the 3 μM, as the best ApoE mimetic peptide dose for the RT-PCR studies. Briefly, proximal intestinal samples were immediately immersed and frozen in ...
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A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells
... 7-13 peptide could mimic the effects of the wild-type Fhit protein on A549 and Calu- 2 lung cancer cell lines, cells were treated with a single administration of 50, 100 or 150 µM Fhit Tat-7-13 peptide and ...
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CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus
... CK2.1 peptide released relative to the initial loading), or HGP alone intra-articularly once every 2 ...on peptide loading data that show release of ...
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TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice
... synthetic peptide (DPS-1), designed based on original protein sequence of TGFβ family, which is part of receptor-binding sequence, ...phase peptide synthesis ...crude peptide was dried under ...
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Treatment with apolipoprotein A 1 mimetic peptide reduces lupus like manifestations in a murine lupus model of accelerated atherosclerosis
... novel peptide, our suboptimal dose of pravastatin alone did not significantly control the pro- gression of either renal deterioration, production of IgG autoantibodies to dsDNA or oxPLs, or formation of ath- ...
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<p>A carbohydrate mimetic peptide modified size-shrinkable micelle nanocluster for anti-tumor targeting and penetrating drug delivery</p>
... The cellular-uptake results showed that IF-7-MNC could be signi fi cantly internalized by A549 cells and HUVEC cells, while the penetration of IF-7- MNC could be more prominent into the 3[r] ...
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Enhanced Recognition and Neutralization of HIV-1 by Antibody-Derived CCR5-Mimetic Peptide Variants
... CCR5 mimetic immunoadhesin can bind to gp120 monomers of an envelope glycoprotein trimer (14), perhaps more effectively preventing virus association with the ...CCR5- mimetic peptides can decrease the off ...
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ApoE mimetic peptide decreases Aβ production in vitro and in vivo
... phase peptide synthesis (SPPS) with acetylation of the N-terminus and amidation at the ...dimer peptide has signaling properties comparable to full-length apoE (Tolar et ...
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A Tyrosine-Sulfated CCR5-Mimetic Peptide Promotes Conformational Transitions in the HIV-1 Envelope Glycoprotein
... CCR5mim and CD4mim bind two gp120 monomers of the HIV-1 envelope glycoprotein. To explore these possibilities di- FIG. 2. CCR5mim-Ig but not CD4-Ig binds two monomers of the HIV-1 envelope glycoprotein trimer. (A) gp120 ...
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Connexin mimetic peptide Gap 27 decreases osteoclastic activity
... 27 peptide in the resorption activity of osteoclasts, utilising the well- characterised pit-formation ...27 peptide would be expected to inhibit junctions constructed of Cx32, Cx40 and Cx43, since the ...
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Peptide Mimetics of Gamma Interferon Possess Antiviral Properties against Vaccinia Virus and Other Viruses in the Presence of Poxvirus B8R Protein
... developed peptide mimetics of gamma interferon (IFN- ␥ ) that play a direct role in the activation and nuclear translocation of STAT1 ␣ transcription ...␥ mimetic peptides were introduced into an adenoviral ...
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